An interventional study of macroabrasion followed by oxidative pretreatment and macroabrasion alone in Molar Incisor Hypomineralization, sponsored by Alexandria University. Not yet recruiting at 1 site in Egypt. Open to participants aged 8 Years to 13 Years. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Alexandria University · Not applicable, Interventional, and Treatment
Background: Resin infiltration often shows unpredictable outcomes in teeth affected by molar incisor hypomineralisation (MIH) due to variable enamel porosities, hypermineralised surface layers, and elevated protein content. Different pretreatment modalities alongside modified resin infiltration protocols have been suggested to enhance aesthetic masking and the required resin infiltration time.
Aim: To compare the effectiveness of transillumination-guided 5.25% NaOCl pretreatment following macroabrasion, with macroabrasion alone, each with 10-second hydrochloric acid (HCl) etching intervals, on aesthetic masking and resin infiltration time required in MIH-affected incisors.
133 studies on the registry are indexed under Molar Hypomineralization; 46 are open to participants now.
This study's planned enrollment of 100 is above the median of 53 across 104 interventional studies indexed under Molar Hypomineralization.
Browse Molar Hypomineralization studies →Alexandria University is the lead sponsor of 604 studies on the registry; 140 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Other: macroabrasion followed by oxidative pretreatment
Other: macroabrasion alone
Fine-grit aluminum oxide finishing stone under water coolant, using a high-speed handpiece to remove the superficial enamel layer, then 5.25% sodium hypochlorite will be applied to the labial lesion surface and agitated with a microbrush for one minute, then rinsed for 20 seconds.
Fine-grit aluminum oxide finishing stone under water coolant, using a high-speed handpiece to remove the superficial enamel layer,
change in aesthetic masking effectiveness
Transillumination images (T0, Tx, Tmax) will be imported into ImageJ (National Institutes of Health, MD, USA), resized, and superimposed to align the labial surfaces. The labial surface and opacity will be manually outlined to measure their respective surface areas. The opacity area ratio will then be calculated as: R = (AO × 100) / AL, where AO is the opacity area and AL is the total labial surface area
Time frame: up to 6 months
change in color stability
2\. Color stability will be calculated based on the changes in the CIE L\*a\*b\* values over time. The color difference (ΔE) between timepoints will be obtained using the following formula: ΔE=√\[(ΔL)2 + (Δa)2 + (Δb)2\].
Time frame: up to 6 months
Changes in the patient-reported SCASS scores
The Schiff Cold Air Sensitivity Scale (SCASS) was used to assess patient-reported dentin hypersensitivity following an air stimulus. The scale ranges from 0 to 3, where 0 indicates no response to the stimulus, 1 indicates a response without requesting discontinuation, 2 indicates a response accompanied by a request to stop the stimulus or withdrawal from it, and 3 indicates a painful response with an immediate request to discontinue the stimulus and/or marked painful behavior. Higher SCASS scores indicate greater dentin hypersensitivity.
Time frame: up to 6 months
change in patient satisfaction
5-point Likert scale for the patients' satisfaction. higher socres mean more satisfaction
Time frame: up to 6 months
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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