Mitochondrial Diseases: all 189 studies
Page 1 of 2. Open to participants first (60), then studies with results posted, then the rest; newest registration first within each.
- Efficacy and Safety of Modafinil to Treat Fatigue in People With Mitochondrial Disease.Not yet recruitingNCT07887412Phase 3
- A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy AdultsNot yet recruitingNCT07869654Phase 1
- Natural History and Genotype-Phenotype Correlations in Mitochondrial LeukoencephalopathiesRecruitingNCT07868796
- The Precision Mito- Mito Map COMPASS StudyNot yet recruitingNCT07856121
- MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10Not yet recruitingNCT07772336Not applicable
- Metabolic and Functional Study of γδ T Cells in Critically Ill PatientsRecruitingNCT07680816
- Validation of the Snouda Metabolic Score for Phenotyping and Guiding Reversal in Type 2 DiabetesEnrolling by invitationNCT07606872Not applicable
- Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and SenescenceNot yet recruitingNCT07596615Not applicable
- Healthy Eating and Active Living for People Living With Multiple Sclerosis (HEAL MS): A Lifestyle Program for People With Multiple SclerosisNot yet recruitingNCT07589062Not applicable
- Open Label Extension to Assess Long Term Safety and Efficacy of KL1333 in Patients With Primary Mitochondrial DiseaseRecruitingNCT07514338Phase 2
- Development of a New Technique for Quantifying Mitochondrial DNA in Single Muscle FibersNot yet recruitingNCT07511608Not applicable
- Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and NeuroimagingNot yet recruitingNCT07474779Not applicable
- Exercise Training Effects on Muscle Function in Adults With Mitochondrial MyopathyRecruitingNCT07450690Not applicable
- Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female InfertilityRecruitingNCT07404969Not applicable
- Efficacy and Safety Study of Bilateral IVT Injection of GS010 at Two Dose Levels in LHON PatientsRecruitingNCT07303296Phase 2
- Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic NeuropathyNot yet recruitingNCT07258667Phase 1
- Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID PatientsRecruitingNCT07134673
- Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural CellsRecruitingNCT06967831
- Expanded Access Program for R007 (Probucol) Tablets in Adults With Mitochondrial Disease and Chronic Kidney DiseaseAvailableNCT06931834
- Neurometabolic Profile of Individuals With Primary Mitochondrial DiseaseRecruitingNCT06890520
- Validation of Nanosensor Oxygen MeasurementRecruitingNCT06819683Phase 1
- A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)Not yet recruitingNCT06792500Phase 1/2
- Effect of High Protein Diet on Hepatic Steatosis in Patients With MAFLDNot yet recruitingNCT06749704Not applicable
- The Effect of the Nutraceutical (-)- Epicatechin on Myosteatosis in Patients With Advanced CKDRecruitingNCT06631820Not applicable
- Combating the Diagnostic Impasse in Mitochondrial Diseases: a Transcriptomic Approach in Fibroblasts and Blood CellsRecruitingNCT06621732Not applicable
- Periodic Fasting for Treatment of Long Covid in Adults: a Pilot StudyRecruitingNCT06522750Not applicable
- Coenzyme Q10 for Gulf War Illness: A Replication StudyRecruitingNCT06515184Phase 3
- The Natural History of Mitochondrial DiseasesRecruitingNCT06504433
- Environmental Pollutants in COPD and Lung CancerRecruitingNCT06483490
- KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial DiseasesRecruitingNCT06451757Phase 3
- Establishment of Reproductive Cohort and Prediction Model of Genetic Counseling for Mitochondrial Genetic DiseasesEnrolling by invitationNCT06450964
- Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial DysfunctionNot yet recruitingNCT06433427
- Genetic Diagnosis in Inborn Errors of MetabolismEnrolling by invitationNCT06376279
- Red Light Ptosis Proof-of-ConceptRecruitingNCT06292182Not applicable
- Coloured-light in Retinitis Pigmentosa.Not yet recruitingNCT06224114Not applicable
- Mitochondrial Disease-associated ImmunoDeficienciesRecruitingNCT06213103
- Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) CohortRecruitingNCT06167135
- Evaluate the Safety and Therapeutic Effects of a Single Intravenous Infusion (IV) of Autologous CD34+ Cells Enriched With Allogenic Placenta-derived Mitochondria in Patients With a Diagnosis of Pearson Syndrome (PS)RecruitingNCT06017869Phase 2
- Mitochondrial Substrate Utilization in the Diabetic Human HeartRecruitingNCT05958706
- Exploring Biomarkers in Hereditary Transthyretin AmyloidosisRecruitingNCT05929209Not applicable
- Applying pGz in Mitochondrial DiseaseRecruitingNCT05569122Phase 1
- Global Registry and Natural History Study for Mitochondrial DisordersRecruitingNCT05554835
- CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney DiseaseRecruitingNCT05422534Phase 3
- Natural History Study of Mitochondrial MyopathyRecruitingNCT05250375
- Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione LevelsRecruitingNCT05241262Phase 1
- MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial DiseasesRecruitingNCT04920812
- Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion SyndromeRecruitingNCT04802707Phase 2
- CrCest Study in Primary Mitochondrial DiseaseEnrolling by invitationNCT04734626
- An Intermediate Size Expanded Access Protocol of ElamipretideAvailableNCT04689360
- Acute Infection in Mitochondrial Disease: Metabolism, Infection and ImmunityRecruitingNCT04419870
- Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental DisordersRecruitingNCT04322734
- Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical StudyRecruitingNCT04288635
- Peripheral Vascular REactivity and Muscular Oxygenation in Diabetes MellitusRecruitingNCT04226820Not applicable
- Idebenone for the Preventive Treatment of MigraineRecruitingNCT04151472Phase 3
- Mitochondrial Donation: An 18 Month Outcome Study.RecruitingNCT04113447
- Validation of Oxygen Nanosensor in Mitochondrial MyopathyRecruitingNCT04086329Phase 1
- Tissue Sample Study for Mitochondrial DisordersEnrolling by invitationNCT01803906
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168
- The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of MetabolismRecruitingNCT01780168
- North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)RecruitingNCT01694940
- Mitochondrial Stress, Brain Imaging, and EpigeneticsCompletedNCT04831424Not applicableResults posted
- Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)TerminatedNCT04475549Phase 2Results posted
- A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory EpilepsyTerminatedNCT04378075Phase 2/3Results posted
- Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum DisorderCompletedNCT03835117Phase 2Results posted
- RESCUE and REVERSE Long-term Follow-upCompletedNCT03406104Phase 3Results posted
- Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic CapacityCompletedNCT03351998Phase 4Results posted
- Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 YearCompletedNCT03293524Phase 3Results posted
- Mitochondria and Chronic Kidney DiseaseCompletedNCT03177798Phase 2Results posted
- Assessment of Small Fiber Neuropathy in Rare Diseases Using SudoscanCompletedNCT02985710Not applicableResults posted
- Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial Myopathy (PMM)TerminatedNCT02976038Phase 2Results posted
- Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE)CompletedNCT02652780Phase 3Results posted
- Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 MutationCompletedNCT02652767Phase 3Results posted
- A Dose-escalating Clinical Trial With KH176CompletedNCT02544217Phase 1Results posted
- Heart Rate Variability in Response to Metformin ChallengeCompletedNCT02500628Phase 2Results posted
- A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial DiseaseTerminatedNCT02473445Phase 2Results posted
- A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's AtaxiaCompletedNCT02255435Phase 2Results posted
- A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in ElderlyCompletedNCT02245620Phase 2Results posted
- Anesthesia in Patients With Mitochondrial DiseaseTerminatedNCT02053766Not applicableResults posted
- Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)CompletedNCT01831934Phase 4Results posted
- EPI-743 for Metabolism or Mitochondrial DisordersCompletedNCT01642056Phase 1/2Results posted
- Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar DepressionCompletedNCT01390389Not applicableResults posted
- Switching From Efavirenz to Atazanavir/ Ritonavir in HIV-infected Subjects With Good Virologic SuppressionTerminatedNCT01194856Phase 4Results posted
- Phase III Trial of Coenzyme Q10 in Mitochondrial DiseaseCompletedNCT00432744Phase 3Results posted
- Clinical Trial of High Dose CoQ10 in ALSCompletedNCT00243932Phase 2Results posted
- A Multi-Dimensional Model of cAre and transItion for Patients With cOmplex RAre DiseasesActive, not recruitingNCT07558213
- Vatiquinone Expanded Access ProtocolNo longer availableNCT07159139
- Efficacy and Safety of Different Dosages of Mexidol® in Patients With Primary Open-angle Glaucoma (POAG)CompletedNCT06903156Phase 2
- Enhancement of Quality of Work And LifeActive, not recruitingNCT06573866Not applicable
- Digital Health Technology for People With Mitochondrial DiseaseCompletedNCT06535646Not applicable
- Fat Oxidation Capacity in Patients With Post Covid-19 SyndromeCompletedNCT06468722
- MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)CompletedNCT06437639Phase 4
- Atypical Antipsychotic-induced Mitochondrial Dysfunction in Patients With SchizophreniaCompletedNCT06236451Phase 4
- MItochondrial Diabetes LOw Carb- Diet StudyCompletedNCT06185790Not applicable
- Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin ResistanceCompletedNCT06080594Not applicable
- Mitochondrial Dysfunctions Driving Insulin ResistanceCompletedNCT06080581
- Human Mitochondrial Stress-driven Obesity ResistanceCompletedNCT06080568
- Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).CompletedNCT06051448Phase 1/2
- In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue.Status unknownNCT05753228Not applicable
- Reference Values of Intraepidermal Nerve Fiber Density in Children and Small Fiber Neuropathy in Neurodevelopmental DisordersCompletedNCT05645874
- The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and RemodellingActive, not recruitingNCT05483738Not applicable