Mitochondrial Diseases: all 189 studies

Page 2 of 2. Open to participants first (60), then studies with results posted, then the rest; newest registration first within each.

• Safety and Efficacy of Oral Idebenone for Preventive Treatment of Migraine in Adult Migraine PatientsStatus unknownNCT05411978Phase 4
• Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)CompletedNCT05162768Phase 3
• Efficacy, Safety, Tolerability of AXA1125 in Fatigue After COVID-19 InfectionCompletedNCT05152849Phase 2
• A Retrospective Study of Subjects With Thymidine Kinase 2 DeficiencyCompletedNCT05017818
• Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial MedicineCompletedNCT05012358
• The KHENERGYC StudySuspendedNCT04846036Phase 2
• Getting Global Rare Disease Insights Through Technology StudyStatus unknownNCT04758130Not applicable
• Drug-drug Interaction Study of KL1333 in Healthy SubjectsCompletedNCT04643249Phase 1
• The KHENEREXT StudyCompletedNCT04604548Phase 2
• Natural History Study of SLC25A46 Mutation-related MitochondriopathyCompletedNCT04594590
• A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)WithdrawnNCT04581733Phase 3
• Natural History Study of FDXR Mutation-related MitochondriopathyCompletedNCT04580979
• A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or DeletionWithdrawnNCT04548843Phase 1
• Clinical Study of Hydroxytyrosol (HT) in Mitochondrial DiseasesCompletedNCT04543968Not applicable
• The KHENERGYZE StudyCompletedNCT04165239Phase 2
• Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury (AKI) in Postoperative Cardiac SurgeryCompletedNCT04125069
• Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read GenomicsCompletedNCT03962452Not applicable
• Nicotinamide Riboside and Mitochondrial MetabolismCompletedNCT03951285Not applicable
• A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial DiseaseCompletedNCT03888716Phase 1
• Trial of Erythrocyte Encapsulated Thymidine Phosphorylase In Mitochondrial Neurogastrointestinal EncephalomyopathyWithdrawnNCT03866954Phase 2
• Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA ChipCompletedNCT03857880
• An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 DeficiencyCompletedNCT03845712Phase 2
• Executive Function Disorders and Anxio-depressive Symptomatology in Children and Adolescents With Mitochondrial PathologiesCompletedNCT03832218Not applicable
• Combined Antioxidant Therapy on Oxidative Stress, Mitochondrial Dysfunction Markers in Diabetic RetinopathyCompletedNCT03702374Phase 3
• Diagnostic Odyssey Survey 2CompletedNCT03678740
• EAP_GS010_single PatientNo longer availableNCT03672968
• Treatment of TK2 Deficiency With Thymidine and DeoxycytidineActive, not recruitingNCT03639701Phase 1/2
• Imaging Neuromelanin and Iron in Dystonia/ParkinsonismStatus unknownNCT03572114
• Mitochondria in HIV and Aging (MITO+)CompletedNCT03489421
• Nicotinamide Riboside and Mitochondrial BiogenesisCompletedNCT03432871Not applicable
• A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular "Powerhouse") DysfunctionCompletedNCT03421899
• Low Residue Diet Study in Mitochondrial DiseaseCompletedNCT03388528Not applicable
• A Study to Evaluate the Safety and Therapeutic Effects of Transplantation of MNV-BM-BLD in Pediatric Patients With Pearson SyndromeCompletedNCT03384420Phase 1/2
• REALITY LHON RegistryCompletedNCT03295071
• DNA QUANTIFICATION TECHNIQUE AS A INTERPRETATION TOOL IN MITOCHONDRIAL DISEASESCompletedNCT03216252Not applicable
• Mitochondrial and Microbiota RelationshipCompletedNCT03213067
• Perioperative Early Tiredness (Acute Fatigue) in Patients With Epithelial Ovarian CancerCompletedNCT03131102
• Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male VolunteersCompletedNCT03056209Phase 1
• Muscle OXPHOS and Nutrient HomeostasisCompletedNCT02920671
• The KHENERGY StudyCompletedNCT02909400Phase 2
• The Effect of Arginine and Citrulline Supplementation on Endothelial Dysfunction in Mitochondrial DiseasesCompletedNCT02809170Not applicable
• Mitochondrial Cocktail for Gulf War IllnessCompletedNCT02804828Not applicable
• GDF-15 as a Biomarker for Mitochondrial DiseaseCompletedNCT02745938
• Calf Muscle Strength in Mitochondrial DiseasesCompletedNCT02678637
• A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly SubjectsCompletedNCT02655393Phase 1
• Role of Allopurinol on Oxidative Stress and Mitochondrial Alterations in Skeletal Muscle of Diabetic PatientsCompletedNCT02533648Phase 3
• A Study of Bezafibrate in Mitochondrial MyopathyCompletedNCT02398201Phase 2
• Nutritional Assessment in Mitochondrial CytopathyCompletedNCT02375438
• Long-Term Safety and Efficacy Evaluation of EPI-743 in Children With Leigh SyndromeCompletedNCT02352896Phase 2
• Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?Status unknownNCT02348125Phase 1
• Survey on Supplement Use in Mitochondrial DiseaseCompletedNCT02311257
• DINAMITE Study Nutritional State and Effect Diet in Mitochondrial DiseaseCompletedNCT02286856Not applicable
• Glycemic Index in Mitochondrial DiseaseCompletedNCT02284334
• An Exploratory Open Label Study of EPI-743 (Vincerinone TM) in Children With Autism Spectrum DisorderWithdrawnNCT02226458Phase 2
• Magnetic Resonance Imaging (MRI) Muscle Phenotyping in Mitochondrial DiseaseCompletedNCT02154711
• Statins for Oxidative Stress and Mitochondrial Function in Diabetic PolyneuropathyCompletedNCT02129231Phase 2
• Protective Effects of L-arginine During Reperfusion by Femoropopliteal Bypass for Lower Limb Ischemic Syndrome in HumansCompletedNCT02117206Phase 4
• Phase 2 Study of EPI-743 in Children With Pearson SyndromeTerminatedNCT02104336Phase 2
• Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic RetinopathyCompletedNCT02062034Phase 2
• Etiology and Early Diagnosis of Neurodevelopmental DisordersCompletedNCT02003170
• Mitochondrial Dysfunction in Autism Spectrum DisorderActive, not recruitingNCT02000284
• Mitochondrial Dysfunction in Phelan-McDermid SyndromeCompletedNCT02000167
• Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment StrategiesCompletedNCT01970332Not applicable
• Therapy for Chronic Fatigue Syndrome: A Presumptive Mitochondrial DisorderWithdrawnNCT01872351
• GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)CompletedNCT01854294Phase 2
• Energy Requirements in Mitochondrial DiseaseCompletedNCT01776918
• Safety and Efficacy Study of EPI-743 in Children With Leigh SyndromeCompletedNCT01721733Phase 2
• Co Enzyme Q10 Improves IVF Outcome in With Advanced Reproductive AgeStatus unknownNCT01659788Not applicable
• Thyroid Study Type 2 Diabetes Mellitus (T2DM)Status unknownNCT01379170Phase 4
• EPI-743 for Mitochondrial Respiratory Chain DiseasesNo longer availableNCT01370447
• Relation Between Subclinical Hypothyroidism and Outcome of PregnancyCompletedNCT01335802
• Exercise Versus Diet in the Treatment of Nonalcoholic Fatty Liver DiseaseCompletedNCT01327443Not applicable
• Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial MyopathyCompletedNCT01301235
• Mechanisms of Mitochondrial Defects in Gulf War SyndromeCompletedNCT01264471
• Ketones & Mitochondrial HeteroplasmyCompletedNCT01252979Early Phase 1
• Longitudinal Study of Mitochondrial HepatopathiesSuspendedNCT01148550
• Gastrointestinal Dysfunction in Children Affected With Mitochondrial DisordersCompletedNCT01137240
• The Effect of Co Enzyme Q10 Together With Fertility Drugs on Pregnancy Outcome of in Vitro FertilizationTerminatedNCT01048385Not applicable
• Anesthetic Effects in Mitochondrial DiseaseTerminatedNCT01001585Not applicable
• resVida and Fat OxidationCompletedNCT00998504Not applicable
• Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric ObesityStatus unknownNCT00962806Not applicable
• Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.Status unknownNCT00831948
• Economic and Medical Evaluation of the Whole Mitochondrial DNA Screening by Surveyor and Mitochips TechniquesCompletedNCT00829270
• Mitochondria Inborn Errors of Metabolism and ANT Defects in Mitochondria DiseasesCompletedNCT00786539
• Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)TerminatedNCT00712426Phase 3
• Abdominal Adiposity and Muscle Mitochondrial FunctionsCompletedNCT00446745
• Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni SyndromeCompletedNCT00406445
• Evaluating the Effectiveness of a Dichloroacetate in MELAS SyndromeStatus unknownNCT00068913Phase 2
• RG2133 (2',3',5'-Tri-O-Acetyluridine) in Mitochondrial DiseaseTerminatedNCT00060515Phase 1

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