Margins of Excision clinical trials
The registry lists 93 studies for Margins of Excision across more than 10 countries. 37 are recruiting or about to start. 16 of them are mainly about Margins of Excision (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Rigshospitalet, Denmark (2) · Peking University Cancer Hospital & Institute (2) · Aarhus University Hospital (2) · Samsung Medical Center (2) · Region Örebro County (2) · Centre Hospitalier Universitaire, Amiens (2) · Yunnan Cancer Hospital (2) · Wuhan Union Hospital, China (2)
What is being tested here
Drugs under test in Margins of Excision studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Indocyanine Green | 1 | 1 | 3 |
| Timolol | 1 | 0 | 1 |
| Everolimus | 0 | 0 | 2 |
| Multi-kinase Inhbitor AIV001 | 0 | 0 | 1 |
| Risankizumab | 0 | 1 | 1 |
| Simvastatin | 0 | 0 | 1 |
| Varlilumab | 0 | 0 | 1 |
| Sunitinib | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 9
- Dec 2026A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast Cancer · Guangdong Provincial People's Hospital
- Mar 2027Factors Influencing Breast Cancer Resection Volumes And Their Impact on Treatment Outcome (FIBRATIO) · Tampere University Hospital
- Apr 2027PIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors · Rigshospitalet, Denmark
- Apr 2027Intra-operative Detection of Positive Margins and Lymph Nodes in Breast Surgery · University of Nottingham
- Jun 2027Application of SERS Technology Based Intraoperative Navigation System in Lung Cancer · Shanghai Pulmonary Hospital, Shanghai, China
- Jun 2027Impact of Systematic Shaving on Margins · Hospital Universitari de Bellvitge
- Aug 2027Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer · Royal Marsden NHS Foundation Trust
- Aug 2027SPECTRA: Intraoperative Hyperspectral Imaging for Prostate Cancer · Massimo Valerio
- Sep 2027Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds Healing · University of California, Davis
Who these studies take
Of the 24 Margins of Excision studies recruiting now, 18 (75%) set no upper age limit and 5 (21%) stop at 75 or younger. 2 (8%) take children under 18. 5 (21%) are for women only and 3 (13%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (8%) | 1 (4%) |
| 18 | 20 (83%) | 18 (75%) |
| 30 | 21 (88%) | 19 (79%) |
| 40 | 21 (88%) | 19 (79%) |
| 50 | 21 (88%) | 19 (79%) |
| 65 | 20 (83%) | 18 (75%) |
| 75 | 18 (75%) | 16 (67%) |
| 85 | 17 (71%) | 15 (63%) |
Across all 93 studies, recruiting or not: 23% stop at 75 or younger and 8% at 65; 13% take children; 22% are for women only and 11% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Margins of Excision studies take
Of 28 interventional studies with no phase under Margins of Excision, half reached primary completion within 30 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 30 mo10–63 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 93. Browse all 93 → or search them.
- Biomechanical Characterization of Skin Properties Using Impact Based-Analysis Method (IBAM)Not yet recruitingNCT07861022
- Impact of Systematic Shaving on MarginsRecruitingNCT05782686Not applicable1 country
- SPECTRA: Intraoperative Hyperspectral Imaging for Prostate CancerRecruitingNCT07826858Not applicable1 country
- Defining the Ablative Dose for Y-90 TARERecruitingNCT07586046Phase 21 country
- Stereotactic Radiation for Growing/Changing Brain Metastases With Same-Day Radiation Planning and Treatment With Margin ReductionRecruitingNCT07132190Phase 21 country
- Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CDRecruitingNCT07680283Not applicable1 country
- Individualized Primary Clinical Target Volume Based on Margin Expansion for Nasopharyngeal CarcinomaRecruitingNCT07661771Phase 31 country
- Efficacy and Safety of Topical Timolol in Secondary Intention Surgical Wounds HealingNot yet recruitingNCT07384767Phase 21 country
- Intra-operative Detection of Positive Margins and Lymph Nodes in Breast SurgeryRecruitingNCT069776981 country
- Intraoperative Molecular Imaging Using ICG for Head and Neck TumorsRecruitingNCT07149207Phase 21 country
- A Novel Intraoperative Fluorescence-guided System for Evaluating Margins During Breast-conserving Surgery for Breast CancerRecruitingNCT07352930Not applicable1 country
- Spectroscopic Analysis of Tongue Tumor Samples.RecruitingNCT051046191 country
- Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid TumorsRecruitingNCT07517198Phase 11 country
- PIRe 2.0: A Stepped-Care Model for Involving Relatives Across SectorsNot yet recruitingNCT07590726Not applicable1 country
- A Study to Evaluate the Performance of Confocal Microscopy to Detect Positive Margins During Radical ProstatectomyRecruitingNCT07541911Not applicable1 country
- Infiltration Pattern of Locally Advanced ESCCEnrolling by invitationNCT075677161 country
- HISMAR: Intraoperative Margin Assessment Using the Histolog® Scanner to Reduce Reoperation in Breast-Conserving SurgeryNot yet recruitingNCT07527468Not applicable1 country
- Intraoperative Use of I.V. Sodium Fluorescein in Suspected CNS TumorsRecruitingNCT072339541 country
- Impact of Preoperative High-Frequency Ultrasound Cutaneous Lesion Extent Assessment on Excision Margin Positivity in Head and Neck Skin Cancer, and the Relationship Between Preoperative Assessment Methods, Inadequate Excision Margins, and Tumor RecurrenceNot yet recruitingNCT073616661 country
- A Prospective Clinical Study Investigating the Use of the Histolog Scanner for Intraoperative Assessment of Surgical Margins in Patients Undergoing Breast-conserving Surgery for Histologically Confirmed Breast Cancer. The Histolog Scanner Operates on the Principle of Confocal MicroscopNot yet recruitingNCT073415421 country
- EpCAM-Targeted Surface-Enhanced Raman Spectroscopy Nanotags for Rapid Evaluation of Surgical Margins and Sentinel Lymph Node Metastasis Status in Breast CancersNot yet recruitingNCT070185051 country
- Cellvizio to Evaluate Margins in Crohn's Ileal DiseaseRecruitingNCT05805020Not applicable1 country
- B7-H3 NIR Imaging for Osteosarcoma SurgeryRecruitingNCT06778603Phase 1/21 country
- Predicting Treatment Failure in HSIL Patients with Positive Margins After Conization Via Detection of PAX1 MethylationNot yet recruitingNCT067136551 country
- Safety & Efficacy of a Novel Asymmetrical Linear Stapler (NALS) for Securing Distal Resection Margin in Laparoscopic Rectal Cancer Surgery: Pilot StudyNot yet recruitingNCT06709170Not applicable1 country
- Evaluation Clinique Des Performances Du Dispositif D'Aide À La Chirurgie DyameoNot yet recruitingNCT06618170
- Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal CancerRecruitingNCT059338891 country
- Robot-assisted Function-sparing Cystectomy Followed by Modified Orthotopic Ileal NeobladderRecruitingNCT05881642Not applicable1 country
- Dermatoscopy Guided Resection for Skin CancerRecruitingNCT06342297Not applicable1 country
- The Application of Probe Confocal Laser Endomicroscopy in Pancreatic Tumor SurgeryRecruitingNCT06289803Not applicable1 country
- Proximally Extended Resection for Rectal Cancer After Neoadjuvant ChemoradiotherapyRecruitingNCT02649647Not applicable1 country
- Mesopancreas Study in Pancreatic CancerNot yet recruitingNCT058952141 country
- Application of SERS Technology Based Intraoperative Navigation System in Lung CancerNot yet recruitingNCT05881057
- The Value of MRI in Assessing the Status of Retroperitoneal Resection Margin in Colon CancerRecruitingNCT05859581Not applicable1 country
- Induction Chemotherapy for Locally Recurrent Rectal CancerRecruitingNCT04389086Phase 35 countries
- Omitting vs. Doing Intraoperative Frozen Section Biopsy for Margin Status in Breast Conserving SurgeryRecruitingNCT03975179Not applicable1 country
- Wide Margin vs. Narrow Margin in Postneoadjuvant LumpectomyRecruitingNCT03417622Phase 31 country
- Comparative Research on the Accuracy of Margin Interpretation in Breast-Conserving Surgery for Breast Cancer: Cell Microscopic Imaging and Standard Frozen PathologyCompletedNCT07029646Not applicable1 country
- Performance of 18F-FDG Micro-PET-CT in the Assessment of Surgical Margins in Head and Neck CancerCompletedNCT07285564Not applicable1 country
- Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy SpecimenCompletedNCT07141121Not applicable1 country
- Intraoperative Assessment of Surgical Margins Using Confocal Microscopy in Comparison With Reference Extemporaneous ExaminationCompletedNCT05935995Not applicable1 country
- Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung CancerActive, not recruitingNCT04073745Phase 11 country
- Development and Implementation of an Intervention Enhancing Involvement of Relatives to Patients With Acquired Brain Injury or Malignant Brain TumourCompletedNCT067963351 country
- Margin Intraoperative CT Feedback Feedback StudyActive, not recruitingNCT07242053Not applicable1 country
- Evaluation of Safety and Performance of Intraoperative Detection of Light Signals During Electrosurgical Breast Cancer ResectionCompletedNCT06020573Not applicable1 country
- Trop2-targeting NIR-II Molecular Probe for Breast Cancer Precise SurgeryCompletedNCT067136811 country
- The Comparison of Navigational Bronchoscopic and CT-Guided Preoperative Markings in Minimally Invasive Thoracic SurgeryCompletedNCT06957600Not applicable1 country
- Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue CancersTerminatedNCT04738786Not applicable1 country
- Preoperative Magnetic Resonance Imaging to Obtain Adequate Resection Margins in Breast Conserving Surgery, (PRIMAR) TrialTerminatedNCT05825768Not applicable1 country
- Study to Evaluate a New Method to Detect Residual Tumours During Surgery for Prostate Cancer Using Confocal MicroscopyCompletedNCT06398470Phase 1/21 country