Lymphoma, Extranodal NK-T-Cell clinical trials
The registry lists 270 studies for Lymphoma, Extranodal NK-T-Cell across more than 10 countries. 36 are recruiting or about to start. 137 of them are mainly about Lymphoma, Extranodal NK-T-Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
National Cancer Institute (NCI) (22) · Fred Hutchinson Cancer Center (15) · Mayo Clinic (11) · Sun Yat-sen University (11) · City of Hope Medical Center (9) · Ruijin Hospital (9) · Case Comprehensive Cancer Center (7) · Beijing Tongren Hospital (7)
What is being tested here
Drugs under test in Lymphoma, Extranodal NK-T-Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Selinexor | 2 | 0 | 2 |
| Golidocitinib | 2 | 0 | 2 |
| Fludarabine | 1 | 0 | 19 |
| Busulfan | 1 | 0 | 11 |
| Methotrexate | 1 | 1 | 7 |
| Azacitidine | 1 | 0 | 4 |
| Thiotepa | 1 | 0 | 3 |
| Sintilimab | 1 | 0 | 3 |
| Stapokibart | 1 | 0 | 1 |
| TR115 | 1 | 1 | 1 |
Drug classes tested here Immune checkpoint inhibitors 4 open · Antimetabolites 3 open · Alkylating agents 2 open · Tyrosine kinase inhibitors (TKIs) 2 open · JAK inhibitors 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Pembrolizumab and Radiotherapy for Patients With NK/T Cell Lymphoma · International Extranodal Lymphoma Study Group (IELSG)
- Dec 2026A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas · Dren Bio
- Dec 2026A Phase II Study of Dexamethasone, Azacitidine, Pegaspargase and Tislelizumab Plus Radiotherapy for Patients With Stage I/II Extranodal NK/T-cell Lymphoma · Peking University Cancer Hospital & Institute
- Dec 2026Circulating Tumor DNA in Peripheral T-cell Lymphomas · University of Aarhus
- Dec 2026RD13-02 Cell Injection in Patients with Relapsed or Refractory CD7-Positive Natural Killer/T Cell Malignancies · Wuhan Union Hospital, China
- Jun 2027Allogeneic CD30.CAR-EBVSTs in Patients With Relapsed or Refractory CD30-Positive Lymphomas · Baylor College of Medicine
- Jul 2027Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCL · Ruijin Hospital
Who these studies take
Of the 20 Lymphoma, Extranodal NK-T-Cell studies recruiting now, 11 (55%) set no upper age limit and 8 (40%) stop at 75 or younger. 4 (20%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (10%) | 2 (10%) |
| 18 | 18 (90%) | 18 (90%) |
| 30 | 19 (95%) | 19 (95%) |
| 40 | 19 (95%) | 19 (95%) |
| 50 | 19 (95%) | 19 (95%) |
| 65 | 20 (100%) | 20 (100%) |
| 75 | 14 (70%) | 14 (70%) |
| 85 | 12 (60%) | 12 (60%) |
Across all 270 studies, recruiting or not: 41% stop at 75 or younger and 14% at 65; 30% take children; 0% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Lymphoma, Extranodal NK-T-Cell studies take
Of 39 phase 2 interventional studies under Lymphoma, Extranodal NK-T-Cell, half reached primary completion within 64 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 55 mo45–80 · 18 studies | — | — |
| Phase 2 | 64 mo45–99 · 39 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Newly registered1
- Multi-omics Profiling of Relapsed Extranodal Natural Killer (NK)/T-cell LymphomaNov 6, 2026NCT07920757
Studies
Recruiting first, then most recently updated. Showing 50 of 270. Browse all 270 → or search them.
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- A Phase II Study of Stapokibart Combined With Immune Checkpoint Inhibitors in Relapsed/Refractory LymphomaNot yet recruitingNCT07791615Phase 2
- GELAD-Based Response-Adapted Treatment for Early-Stage Extranodal NK/T-Cell LymphomaNot yet recruitingNCT07768943Phase 21 country
- Clinical and Biological Cohort Study of EBV-Positive T/NK-Cell Lymphoproliferative DiseasesRecruitingNCT077270831 country
- BRIDGE-NK: Immunotherapy Versus Chemotherapy Induction Followed by Autologous HSCT in Advanced NKTCLRecruitingNCT07678229Phase 31 country
- Phase 1 Study of JV-394 Autologous Anti-CD94 CAR T for r/r CD94+ T/NK Cell NeoplasmsRecruitingNCT07382817Phase 11 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- Tislelizumab Plus Zeprumetostat for Relapsed or Refractory NK/T-Cell LymphomaRecruitingNCT07502768Phase 1/21 country
- A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic LymphomasRecruitingNCT05475925Phase 1/29 countries
- TR115 VS Investigator's Choice in Relapsed/Refractory Peripheral T/NK Cell LymphomaNot yet recruitingNCT07639879Phase 31 country
- Study of Sugemalimab (or Placebo) Plus PGemOx Regimen in Participants With Extranodal NK/T-Cell LymphomaNot yet recruitingNCT05700448Phase 3
- A Registry for People With T-cell LymphomaRecruitingNCT059781411 country
- Selinexor Combined With Reduced-Dose Radiotherapy For Early-Stage Extranodal NK/T-Cell LymphomaNot yet recruitingNCT07554482Phase 21 country
- Sintilimab, Chidamide, and Azacitidine for Untreated Stage I-II Extranodal NK/T-Cell LymphomaNot yet recruitingNCT07542912Not applicable1 country
- Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)RecruitingNCT07525466Phase 1/21 country
- Phaes Ⅱ Study of Golidocitinib-Pegaspargase-PD-1 Antibody First-Line for Advanced ENKTLNot yet recruitingNCT07457177Phase 2
- Golidocitinib Combined With P-GemOx Plus PD-1 Inhibitor Versus P-GemOx Plus PD-1 Inhibitor in First-Line Newly Diagnosed Advanced or Non-Nasal Extranodal NK/T-Cell LymphomaNot yet recruitingNCT07385989Phase 2
- PET and EBV DNA-directed Therapy for Localized Nasal Extranodal NK/T Cell LymphomaRecruitingNCT06069830Not applicable1 country
- Preconditioning With a Combination of Thiotepa, Cyclophosphamide, and Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of NK/T-Cell LymphomaNot yet recruitingNCT07276737Phase 2
- Clinical Study on Maintenance Therapy With Selinexor Combined With Azacitidine After Allogeneic Hematopoietic Stem Cell Transplantation for NK/T-cell LymphomaNot yet recruitingNCT07276698Phase 2
- Safety and Efficacy of Anti-EBV Autologous TCR-T Cell Injection in Relapsed/Refractory EBV-Positive LymphomaRecruitingNCT07162012Early Phase 11 country
- A Phase II Study of Dexamethasone, Azacitidine, Pegaspargase and Tislelizumab Plus Radiotherapy for Patients With Stage I/II Extranodal NK/T-cell LymphomaRecruitingNCT07000617Phase 21 country
- A Study Comparing of P-GEMD Regimen Versus P-Gemox Regimen With Untreated Early-Stage NUAT or Advanced-Stage ENKTL.Not yet recruitingNCT06953739Phase 3
- The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell LymphomaNot yet recruitingNCT068634411 country
- Sintilimab, Pegaspargase Plus GemOx for Untreated Extranodal NK/T-Cell LymphomaRecruitingNCT06824883Phase 21 country
- The Value of Artificial Intelligence-based 18F-FDG PET/CT in Diferential Diagnosis, Efficacy Prediction and Prognosis Prediction of T-NK Cell Lymphoma: a Clinical StudyNot yet recruitingNCT067472991 country
- RD13-02 Cell Injection in Patients with Relapsed or Refractory CD7-Positive Natural Killer/T Cell MalignanciesRecruitingNCT06732492Phase 11 country
- PET/MR in the Staging and Efficacy Evaluation of Newly Diagnosed NK/T-cell LymphomaRecruitingNCT05662540Not applicable1 country
- Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCLNot yet recruitingNCT06573138Phase 2
- Safety & Efficacy of Peg-ASP-based CCRT in Early Stage ENKTLRecruitingNCT06406556Phase 21 country
- Clinical Study of Anti-CD56-CAR-T in the Treatment of Relapsed/Refractory NK/T Cell Lymphoma /NK Cell LeukemiaRecruitingNCT05941156Phase 21 country
- A Retrospective Study on Extranodal Lymphoma or Lymphoma of Rare Pathological TypesNot yet recruitingNCT059074471 country
- Prognostic Nomogram of Extranodal NK/T-cell LymphomaRecruitingNCT045545111 country
- Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell LymphomaRecruitingNCT05833893Phase 21 country
- Allogeneic Stem Cell Transplantation in Relapsed/Refractory T-, NK/T-cell LymphomasRecruitingNCT02859402Phase 21 country
- The Whole-course Management of Pegaspargase in ENKTLNot yet recruitingNCT05426824Not applicable1 country
- Allogeneic CD30.CAR-EBVSTs in Patients With Relapsed or Refractory CD30-Positive LymphomasActive, not recruitingNCT04288726Phase 11 country
- Vorinostat and Azacitidine in Treating Patients With Locally Recurrent or Metastatic Nasopharyngeal Cancer or Nasal Natural Killer T-Cell LymphomaActive, not recruitingNCT00336063Phase 14 countries
- Multi-omics Profiling of Relapsed Extranodal Natural Killer (NK)/T-cell LymphomaActive, not recruitingNCT079207571 country
- Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid TumorsTerminatedNCT00788125Phase 1/21 country
- Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantActive, not recruitingNCT011995621 country
- A Study to Assess the Safety, Tolerability, Efficacy, and Drug Levels of BMS-986369 (Golcadomide) in Participants With Relapsed or Refractory T-cell Lymphomas in Japan (GOLSEEK-3)Active, not recruitingNCT06035497Phase 1/21 country
- A Study of IMC-001 in Subjects With Relapsed or Refractory Extranodal NK/T Cell Lymphoma, Nasal TypeActive, not recruitingNCT04414163Phase 21 country
- A Study of Tislelizumab, Chemotherapy, and Radiation Therapy for Early-Stage High-Risk ENKTCL (CLCG-2102)CompletedNCT05254899Phase 21 country
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With CancerActive, not recruitingNCT009350901 country
- Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of Anti-CD7 Allogeneic CAR T-Cells (WU-CART-007) in Patients With CD7+ Hematologic MalignanciesSuspendedNCT05377827Phase 11 country
- A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adults With Hodgkin and Non-Hodgkin LymphomaTerminatedNCT05255601Phase 1/27 countries
- Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D InsufficiencyActive, not recruitingNCT01787409Not applicable1 country
- Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell LymphomaCompletedNCT02232516Phase 21 country
- Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other DisordersActive, not recruitingNCT00544115Phase 2