Leukemia, Hairy Cell clinical trials
The registry lists 237 studies for Leukemia, Hairy Cell across more than 10 countries. 18 are recruiting or about to start. 38 of them are mainly about Leukemia, Hairy Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
National Cancer Institute (NCI) (34) · Fred Hutchinson Cancer Center (28) · City of Hope Medical Center (12) · Memorial Sloan Kettering Cancer Center (9) · Northwestern University (7) · Case Comprehensive Cancer Center (6) · Barbara Ann Karmanos Cancer Institute (6) · European Organisation for Research and Treatment of Cancer - EORTC (5)
What is being tested here
Drugs under test in Leukemia, Hairy Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Cladribine | 2 | 1 | 4 |
| Rituximab | 1 | 0 | 13 |
| Vemurafenib | 1 | 0 | 3 |
| Obinutuzumab | 1 | 0 | 3 |
| Binimetinib | 1 | 0 | 2 |
| Zanubrutinib | 1 | 0 | 1 |
| Anti-CD22 CAR-expressing T Lymphocytes | 1 | 0 | 1 |
| Tovorafenib | 1 | 0 | 1 |
| Rocbrutinib | 1 | 0 | 1 |
| Fludarabine | 0 | 0 | 15 |
Drug classes tested here Antimetabolites 2 open · Tyrosine kinase inhibitors (TKIs) 2 open · Alkylating agents 13 · Calcineurin inhibitors 11 · Corticosteroids 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies · MacroGenics
- Jan 2027A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia · Memorial Sloan Kettering Cancer Center
- May 2027Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia · National Cancer Institute (NCI)
- Jun 2027Hairy Cell Leukemia: Harnessing the Full Power of Extracellular Vesicles to Improve Patient Care Management · IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Jun 2027Cladribine and Rituximab in Treating Patients With Hairy Cell Leukemia · M.D. Anderson Cancer Center
- Aug 2027Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia · City of Hope Medical Center
- Sep 2027A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL) · Memorial Sloan Kettering Cancer Center
Who these studies take
Of the 14 Leukemia, Hairy Cell studies recruiting now, 12 (86%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (21%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 13 (93%) | 13 (93%) |
| 30 | 13 (93%) | 13 (93%) |
| 40 | 13 (93%) | 13 (93%) |
| 50 | 13 (93%) | 13 (93%) |
| 65 | 14 (100%) | 14 (100%) |
| 75 | 14 (100%) | 14 (100%) |
| 85 | 14 (100%) | 14 (100%) |
Across all 237 studies, recruiting or not: 21% stop at 75 or younger and 13% at 65; 30% take children; 0% are for women only and <1% for men only; 4% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, Hairy Cell studies take
Of 22 phase 2 interventional studies under Leukemia, Hairy Cell, half reached primary completion within 111 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 60 mo45–95 · 16 studies | — | — |
| Phase 2 | 111 mo64–149 · 22 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 237. Browse all 237 → or search them.
- Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer TreatmentRecruitingNCT010873331 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and VariantRecruitingNCT04815356Phase 11 country
- Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and VariantRecruitingNCT04322383Phase 21 country
- A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)RecruitingNCT06561360Phase 21 country
- Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination TherapiesNot yet recruitingNCT077596611 country
- AutologousCD22 Chimeric Antigen Receptor (CAR)T Cells in w/Recurrent/Refractory B Cell LymphomasRecruitingNCT06340737Phase 11 country
- Testing the Combination of Anti-cancer Drugs, Tovorafenib Plus Rituximab, in Patients With Hairy Cell LeukemiaRecruitingNCT06965114Phase 1/21 country
- Rituximab+ Zanubrutinib for Patients With Hairy Cell Leukemia and Hairy Cell VariantEnrolling by invitationNCT07690761Phase 21 country
- BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Hematologic MalignanciesNot yet recruitingNCT07679919Phase 11 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- Cladribine and Rituximab in Treating Patients With Hairy Cell LeukemiaRecruitingNCT00412594Phase 21 country
- Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.RecruitingNCT04775745Phase 11 country
- Assessment of Disease Burden in Hairy Cell LeukemiaRecruitingNCT06781515Not applicable1 country
- Decoding the Extracellular Vesicles-driven Communication in the Microenvironment of Hairy Cell Leukemia to Improve Patient Care ManagementRecruitingNCT067746771 country
- Hairy Cell Leukemia: Harnessing the Full Power of Extracellular Vesicles to Improve Patient Care ManagementRecruitingNCT067645241 country
- Therapy Optimisation for the Treatment of Hairy Cell LeukemiaRecruitingNCT02131753Phase 2/31 country
- Assessing Medical Trial Experiences of Hairy Cell Leukemia PatientsNot yet recruitingNCT05859932
- Ibrutinib in Treating Patients With Relapsed Hairy Cell LeukemiaActive, not recruitingNCT01841723Phase 21 country
- Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic LeukemiaActive, not recruitingNCT02153580Phase 11 country
- Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantActive, not recruitingNCT011995621 country
- Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaActive, not recruitingNCT01059786Phase 21 country
- Venetoclax for the Treatment of Patients With Relapsed Hairy Cell LeukemiaActive, not recruitingNCT06311227Phase 21 country
- A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell LeukemiaActive, not recruitingNCT03410875Phase 21 country
- Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell LeukemiaActive, not recruitingNCT00923013Phase 21 country
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With CancerActive, not recruitingNCT009350901 country
- A Study of MGD024 in Patients With Relapsed or Refractory Hematologic MalignanciesActive, not recruitingNCT05362773Phase 11 country
- A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin LymphomaActive, not recruitingNCT05283720Phase 213 countries
- Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell LeukemiaActive, not recruitingNCT03805932Phase 11 country
- Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin LymphomaActive, not recruitingNCT01815749Phase 11 country
- Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCLActive, not recruitingNCT04324112Phase 21 country
- ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic MalignanciesCompletedNCT02362035Phase 1/21 country
- Low Dose Vemurafenib and Rituximab in Hairy Cell LeukemiaCompletedNCT05388123Phase 21 country
- A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological MalignanciesCompletedNCT01384513Phase 21 country
- Study of Brexucabtagene Autoleucel in Adults With Rare B-cell MalignanciesTerminatedNCT05537766Phase 28 countries
- Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological MalignanciesCompletedNCT04681105Phase 11 country
- BRAF Inhibitor, Vemurafenib, in Patients With Relapsed or Refractory Hairy Cell LeukemiaCompletedNCT01711632Phase 21 country
- US Post-Marketing Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)TerminatedNCT041252901 country
- CC-486, Lenalidomide, and Obinutuzumab for the Treatment of Recurrent or Refractory CD20 Positive B-cell LymphomaCompletedNCT04578600Phase 11 country
- Understanding the Role of Large Extracellular Vesicles in Lymphomas and Lymphoproliferative Disorders: the "Off the Beaten Track" Liquid BiopsyCompletedNCT067828541 country
- Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 DiabetesCompletedNCT04233034Phase 31 country
- Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic MalignanciesCompletedNCT02924402Phase 14 countries
- A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Escalating Doses of AGS67E Given as Monotherapy in Subjects With Refractory or Relapsed Lymphoid MalignanciesCompletedNCT02175433Phase 12 countries
- Treatment of Hairy Cell Leukaemia Variant and Relapsing Hairy Cell Leukaemia With Cladribine Plus RituximabCompletedNCT02157181Phase 21 country
- Long-term Follow-up Study in Patients Previously Treated With a Mustang Bio CAR-T Cell Investigational Product.TerminatedNCT056457441 country
- Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell TransplantCompletedNCT01588015Phase 11 country
- Ipilimumab and Local Radiation for Selected Solid TumorsTerminatedNCT01769222Phase 11 country
- LMB-2 to Treat Hairy Cell LeukemiaCompletedNCT00321555Phase 21 country
- Busulfan, Cyclophosphamide, & Antithymocyte Globulin Followed by Stem Cell Transplant in Treating Hematologic CancerCompletedNCT00611351Phase 21 country
- Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare CancersCompletedNCT02034110Phase 214 countries