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Hypophosphatasia clinical trials

The registry lists 46 studies for Hypophosphatasia across more than 10 countries. 11 are recruiting or about to start. 44 of them are mainly about Hypophosphatasia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.

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Status

Completed
24
Recruiting
9
Active, not recruiting
4
Status unknown
3
Withdrawn
3
Enrolling by invitation
2

Phase

Phase 2
12
Phase 1
5
Phase 3
4
Phase 4
3

Where

United States
23
Germany
13
United Kingdom
13
Canada
12
Australia
7
France
6

Who runs them

Alexion Pharmaceuticals, Inc. (23) · Sheffield Teaching Hospitals NHS Foundation Trust (3) · AstraZeneca (2) · University of Bonn (2) · RTI International (1) · Emine Hafize (1) · AgNovos Healthcare, LLC (1) · Wuerzburg University Hospital (1)

What is being tested here

Drugs under test in Hypophosphatasia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Asfotase alfa0213
Efzimfotase alfa023
Ilofotase alfa001
Setrusumab001
Methotrexate001
Rituximab001
Bortezomib001
Immunoglobulins, Intravenous001
Immunoglobulin G001
Folic Acid001

Coming up

3phase 3 studies under way
5studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 5

Who these studies take

Of the 9 Hypophosphatasia studies recruiting now, 8 (89%) set no upper age limit and 1 (11%) stop at 75 or younger. 5 (56%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (11%) take healthy volunteers.

Recruiting studies that take each age, of 9
AgeWomenMen
105 (56%)5 (56%)
189 (100%)9 (100%)
309 (100%)9 (100%)
409 (100%)9 (100%)
509 (100%)9 (100%)
658 (89%)8 (89%)
758 (89%)8 (89%)
858 (89%)8 (89%)

Across all 46 studies, recruiting or not: 33% stop at 75 or younger and 30% at 65; 65% take children; 0% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 46 of 46. search them.