Hyperlipoproteinemias clinical trials
The registry lists 34 studies for Hyperlipoproteinemias across more than 10 countries. 5 are recruiting or about to start. 17 of them are mainly about Hyperlipoproteinemias (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 3 narrower conditions too, such as Hyperlipoproteinemia Type II: 338 studies, 69 open.
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Status
Who runs them
Zhejiang University (4) · Akcea Therapeutics (3) · Novartis Pharmaceuticals (3) · Kastle Therapeutics, LLC (3) · National Heart, Lung, and Blood Institute (NHLBI) (2) · S.LAB (SOLOWAYS) (2) · Editas Medicine, Inc. (1) · Ionis Pharmaceuticals, Inc. (1)
What is being tested here
Drugs under test in Hyperlipoproteinemias studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Zodasiran | 1 | 1 | 1 |
| Coenzyme A | 0 | 3 | 4 |
| Mipomersen | 0 | 2 | 3 |
| Vupanorsen | 0 | 0 | 2 |
| Pradigastat | 0 | 1 | 2 |
| Pelacarsen | 0 | 1 | 2 |
| TA-8995 | 0 | 1 | 1 |
| Solbinsiran | 0 | 0 | 1 |
| Pelacarsen sodium | 0 | 0 | 1 |
| Rosuvastatin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
Who these studies take
Of the 3 Hyperlipoproteinemias studies recruiting now, 0 (0%) set no upper age limit and 3 (100%) stop at 75 or younger. 1 (33%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 2 (67%) | 2 (67%) |
| 50 | 2 (67%) | 2 (67%) |
| 65 | 2 (67%) | 2 (67%) |
| 75 | 0 (0%) | 0 (0%) |
| 85 | 0 (0%) | 0 (0%) |
Across all 34 studies, recruiting or not: 38% stop at 75 or younger and 9% at 65; 21% take children; 0% are for women only and 6% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)TerminatedNov 10, 2026NCT05900141
Newly registered2
- Study of YKYY032 Injection in Adults With Hyperlipoproteinemia (a)Nov 3, 2026NCT07914660
- EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)Oct 26, 2026NCT07894887
Studies
Recruiting first, then most recently updated. Showing 34 of 34. search them.
- Study of YKYY032 Injection in Adults With Hyperlipoproteinemia (a)Not yet recruitingNCT07914660Phase 21 country
- EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)Not yet recruitingNCT07894887Phase 1/21 country
- Study of Zodasiran in Adolescent Participants With Homozygous Familial HypercholesterolemiaRecruitingNCT07473843Phase 33 countries
- Clinical Trial On The Effect Of Artisterol On Risk Factors In Individuals With Suboptimal Cholesterol LevelsRecruitingNCT07405814Not applicable1 country
- A Study of SRSD216 in Patients With Elevated Lipoprotein (a)RecruitingNCT07172646Phase 1/21 country
- An Open Label Extension (OLE) Study to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)TerminatedNCT05900141Phase 31 country
- Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.CompletedNCT05425745Phase 310 countries
- Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms.CompletedNCT06163443Not applicable1 country
- Evaluating the Impact of Omega-3 Fatty Acid Supplementation (Soloways™) on Lipid Profiles in Adults With PPARG PolymorphismsCompletedNCT06154408Not applicable1 country
- A Study of LY3561774 in Participants With Mixed DyslipidemiaCompletedNCT05256654Phase 27 countries
- Olezarsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)Approved for marketingNCT063602371 country
- Extracts of Amla, Walnut Leaf, Red Yeast Rice and Olive in Cardiovascular PreventionCompletedNCT06333158Phase 41 country
- Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)CompletedNCT04606602Phase 14 countries
- Dietary Effects on Lipoproteins and Thrombogenic ActivityCompletedNCT00000538Phase 3
- A Dose-Ranging Study With Vupanorsen (TRANSLATE-TIMI 70)CompletedNCT04516291Phase 23 countries
- Volanesorsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS)No longer availableNCT03544060
- Phase 2 Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Chylomicronemia Syndrome (FCS)CompletedNCT03360747Phase 21 country
- Safety, Tolerability,Pharmacokinetics(PK)and Pharmacodynamics(PD)Assessment of LCQ908 in Patients With Severe HypertriglyceridemiaCompletedNCT01146522Phase 1/21 country
- Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular DiseaseCompletedNCT03070782Phase 25 countries
- Plasma Triglyceride Lipolysis in Multifactorial ChylomicronemiaCompletedNCT02933138
- Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial HypercholesterolemiaCompletedNCT00477594Phase 21 country
- Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial HypercholesterolemiaCompletedNCT00607373Phase 37 countries
- An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-HypercholesterolemiaCompletedNCT00694109Phase 37 countries
- Lipid Research Clinics Population StudiesCompletedNCT00005128
- Randomized Controlled Trial of Lipid Apheresis in Patients With Elevated Lipoprotein(a)WithdrawnNCT01064934Not applicable1 country
- A Randomized, Double-blind, Placebo Controlled Study to Assess Efficacy, Safety and Tolerability of LCQ908 in Subjects With Familial Chylomicronemia SyndromeCompletedNCT01514461Phase 38 countries
- Effect of Niacin/Laropiprant on Postprandial Lipoprotein Metabolism in Patients With DyslipoproteinemiaTerminatedNCT01239992Phase 41 country
- The Effects of Coenzyme A Combined With Statin on Serum Lipids in Patients With HyperlipidemiaStatus unknownNCT01928342Phase 2/31 country
- Comparison of Coenzyme A and Fenofibrate for Safety and Efficacy On Patients With HyperlipidemiaCompletedNCT01878227Phase 31 country
- Comparison of Coenzyme A and Pantethine Capsule for Safety and Efficacy On Patients With HyperlipidemiaCompletedNCT01811082Phase 31 country
- The Effects of Coenzyme A on Serum Lipids in Patients With HyperlipidemiaCompletedNCT01645046Phase 2
- Effect of Rosuvastatin on Triglyceride Levels in Mexican Hypertriglyceridemic PatientsCompletedNCT00473655Phase 41 country
- A Study Comparing the Mechanisms of Action of Lifibrol and PravastatinCompletedNCT01057654Phase 31 country
- Lipoprotein Metabolism in Normal Volunteers and Patients With Abnormal Levels of LipoproteinsCompletedNCT000012261 country