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Hyperlipoproteinemia Type II clinical trials

The registry lists 249 studies for Hyperlipoproteinemia Type II across more than 10 countries. 56 are recruiting or about to start. 164 of them are mainly about Hyperlipoproteinemia Type II (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Homozygous Familial Hypercholesterolemia too: 295 studies, 64 open.

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Status

Completed
137
Recruiting
36
Status unknown
27
Not yet recruiting
14
Terminated
14
Active, not recruiting
11

Phase

Phase 3
68
Phase 2
37
Phase 1
19
Phase 4
13
Early Phase 1
6

Where

United States
76
Canada
43
Netherlands
35
United Kingdom
27
China
24
Norway
22

Who runs them

Merck Sharp & Dohme LLC (17) · Organon and Co (9) · Novartis Pharmaceuticals (9) · Amgen (6) · Kastle Therapeutics, LLC (6) · Laval University (6) · University of Pennsylvania (5) · Pfizer (5)

What is being tested here

Drugs under test in Hyperlipoproteinemia Type II studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Inclisiran336
QLC7401323
Lerodalcibep222
Zodasiran112
Omega-3 fatty acid112
2-(AMINOMETHYL)PHENOL101
SYH2070101
SYH2053111
Evolocumab047
Atorvastatin057

Drug classes tested here PCSK9 inhibitors 2 open · Statins 17

Coming up

15phase 3 studies under way
16studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 36 Hyperlipoproteinemia Type II studies recruiting now, 17 (47%) set no upper age limit and 15 (42%) stop at 75 or younger. 17 (47%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (14%) take healthy volunteers.

Recruiting studies that take each age, of 36
AgeWomenMen
1014 (39%)14 (39%)
1829 (81%)29 (81%)
3026 (72%)26 (72%)
4027 (75%)27 (75%)
5028 (78%)28 (78%)
6527 (75%)27 (75%)
7522 (61%)22 (61%)
8520 (56%)20 (56%)

Across all 249 studies, recruiting or not: 39% stop at 75 or younger and 24% at 65; 30% take children; 1% are for women only and 1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Hyperlipoproteinemia Type II studies take

Of 33 phase 3 interventional studies under Hyperlipoproteinemia Type II, half reached primary completion within 24 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 324 mo18–34 · 33 studies23 mo18–34 · 29 studies—
Interventional, no phase29 mo12–41 · 37 studies—37 mo12–51 · 35 studies
Observational76 mo23–… · 32 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Newly registered3

Studies

Recruiting first, then most recently updated. Showing 50 of 249. Browse all 249 → or search them.