Hyperlipoproteinemia Type II: all 249 studies

Page 2 of 3. Open to participants first (52), then studies with results posted, then the rest; newest registration first within each.

• Study to Assess the Tolerability and Efficacy of Anacetrapib (MK-0859) Co-Administered With Statin in Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-020)CompletedNCT01524289Phase 3Results posted
• A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein CholesterolCompletedNCT01475825Phase 3Results posted
• A Safety and Efficacy Study of DRL-17822, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor, in Patients With Abnormal Cholesterol LevelsCompletedNCT01388816Phase 2Results posted
• Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder StudyCompletedNCT01375751Phase 2Results posted
• Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan)CompletedNCT01107743Results posted
• An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial HypercholesterolaemiaCompletedNCT01078675Phase 3Results posted
• Vytorin Reexamination Study (0653A-174)CompletedNCT01070966Results posted
• A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED)CompletedNCT01012219Phase 1Results posted
• Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT00943306Phase 3Results posted
• Low-Density Lipoprotein (LDL) Apheresis Using H.E.L.P. TherapyCompletedNCT00916643Phase 4Results posted
• Atorvastatin Three Year Pediatric StudyCompletedNCT00827606Phase 3Results posted
• 8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT00739999Phase 1Results posted
• A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)CompletedNCT00730236Phase 3Results posted
• Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery DiseaseCompletedNCT00706849Phase 3Results posted
• Evaluation of the Safety, Tolerability and Efficacy of Ezetimibe on a Select Population of Filipinos With Hypercholesterolemia (Study P04748)(COMPLETED)CompletedNCT00704535Results posted
• An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-HypercholesterolemiaCompletedNCT00694109Phase 3Results posted
• Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial HypercholesterolemiaCompletedNCT00607373Phase 3Results posted
• Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial HypercholesterolemiaCompletedNCT00477594Phase 2Results posted
• Effect of Rosuvastatin on Triglyceride Levels in Mexican Hypertriglyceridemic PatientsCompletedNCT00473655Phase 4Results posted
• Carotid IMT (Intima Media Thickening) Study (0524A-041)(TERMINATED)TerminatedNCT00384293Phase 3Results posted
• PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatinCompletedNCT00355615Phase 3Results posted
• IBI306 Monotherapy in Non-Familial Hypercholesterolemia and Mixed HyperlipidemiaActive, not recruitingNCT07473960Phase 3
• A Study to Evaluate the Safety, Efficacy of SYH2053 in Chinese Participants With Non-familial Hypercholesterolemia and Mixed HyperlipidemiaCompletedNCT07421232Phase 2
• Dual vs Triple Lipid-Lowering Therapy in Type 2 Diabetes Mellitus Patients With Elevated LDL CholesterolCompletedNCT07255820Phase 4
• Patterns of Inclisiran Use in the Real World: An Analysis of US DatabasesCompletedNCT07023445
• A Study to Investigate the Effectiveness and Safety of Bempedoic Acid in Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia in TaiwanCompletedNCT06925100Phase 4
• Impact of Rosuvastatin Doses on LDL Levels, CPK Levels and Aspartate Aminotransferase LevelsCompletedNCT06910098Not applicable
• A Real-world Study of Inclisiran Adherence, Treatment Patterns, Patient Characteristics, and Effectiveness in ASCVD Patients With Hypercholesterolemia, ASCVD-risk Equivalent Patients With Hypercholesterolemia and Familial HypercholesterolemiaCompletedNCT06507852
• Unravelling the Impact of Diet on Cardiovascular Health in Treated Heterozygous Familial Hypercholesterolemia.CompletedNCT06389825Not applicable
• An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)Active, not recruitingNCT06331195Not applicable
• Specified Drug-use Survey of Leqvio for s.c. Injection.Active, not recruitingNCT06275724
• Expression of Pro- and Anti-inflammatory Cytokines During Anti-PCSK9 in Familial HypercholesterolemiaCompletedNCT06231459Phase 4
• A VSA003 Phase 1 Study in Chinese Adult Healthy VolunteersCompletedNCT05851066Phase 1
• The Danish Familial Hypercholesterolemia Organized Coronary Screening TrialCompletedNCT05758779Not applicable
• Improving Diagnosis and Clinical Management of Familial Hypercholesterolemia Through Integrated Machine Learning, Implementation Science, and Behavioral EconomicsCompletedNCT05746247Not applicable
• Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Patients With Familial HypercholesterolemiaCompletedNCT05695937Not applicable
• Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech RepublicStatus unknownNCT05638022
• Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial HypercholesterolemiaCompletedNCT05611528Phase 3
• Alirocumab and Plaque Burden In Familial HypercholesterolaemiaCompletedNCT05465278Phase 4
• Equitable Implementation of Cascade Screening for Familial HypercholesterolemiaCompletedNCT05430191
• A Study of VERVE-101 in Patients With Familial Hypercholesterolemia and Cardiovascular DiseaseCompletedNCT05398029Phase 1
• Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial HypercholesterolemiaActive, not recruitingNCT05367310
• Coronary and Heart Effects of Early Treatment in Familial HypercholesterolemiaCompletedNCT05352386Not applicable
• A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH).CompletedNCT05325203Phase 3
• Pilot Study for a National Screening for Familial HypercholesterolemiaStatus unknownNCT05271305
• Improved Diagnosis of Familial Hypercholesterolemia Across the Northland (ID-FH)CompletedNCT05238519Phase 3
• Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemiaCompletedNCT05218005Not applicable
• Unravelling the Impact of Diet on Cardiovascular Health in Heterozygous Familial Hypercholesterolemia.CompletedNCT05181553Not applicable
• Advanced Lipoproptein Profiling and Cardiovascular Risk Stratification in Familial HypercholesterolemiaStatus unknownNCT05066932
• A Prospective Cohort Study on Familial Hypercholesterolemia in Health Examination PopulationStatus unknownNCT04958629
• Evaluate the Efficacy and Safety of IBI306 in Subjects With Homozygous Familial HypercholesterolemiaStatus unknownNCT04948008Phase 2/3
• Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years OldStatus unknownNCT04897113Not applicable
• Cholesterol Disruption in Combination With the Standard of Care in Patients With Advanced Pancreatic AdenocarcinomaActive, not recruitingNCT04862260Early Phase 1
• Diet Quality and Coronary Artery Calcification in Adults With Heterozygous Familial HypercholesterolemiaActive, not recruitingNCT04837638
• Application of PCSK9 Inhibitors in Patients With Heterozygous Familial HypercholesterolemiaStatus unknownNCT04759534Phase 3
• Regeneron 1331 Kinetics Sub-Study HoFHCompletedNCT04722068Not applicable
• Genetic Testing and Motivational Counseling for FHActive, not recruitingNCT04656028Not applicable
• Is Family Screening Improved by Genetic Testing of Familial HypercholesterolemiaCompletedNCT04526457Not applicable
• Universal Familial Hypercholesterolemia Screening in ChildrenCompletedNCT04507984
• Treatment Rates and Compliance to Treatment in Patients With Familial HypercholesterolemiaCompletedNCT04494464
• The Use of Mobile Health Technology and Behavioral Economics to Encourage Adherence in AdolescentsCompletedNCT04458766Not applicable
• A Study to Determine the Safety, Tolerability, and Efficacy of SHR-1209 in Patients With Familial HypercholesterolemiaStatus unknownNCT04455581Phase 2
• Cascade Genetic Testing of Familial HypercholesterolemiaCompletedNCT04419090Not applicable
• Safety and Efficacy of IBI306 in HeFH PatientsCompletedNCT04179669Phase 3
• A Study of PCSK9 Inhibitor AK102 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)CompletedNCT04173793Phase 2
• Identifying and Genotyping Homozygous Familial Hypercholesterolemia (HoFH) PatientsCompletedNCT04148001
• Genetic Causes of Familial HypercholesterolemiaActive, not recruitingNCT04101149
• A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501Active, not recruitingNCT04080050
• A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial HypercholesterolemiaCompletedNCT04031742Phase 2/3
• Clinical Decision Support for Familial HypercholesterolemiaActive, not recruitingNCT03989167Not applicable
• Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT)Status unknownNCT03934320Not applicable
• A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFHCompletedNCT03933293Phase 2
• Familial Hypercolerstremia as Risk Factor in Stemi Patient Who Underwent PpciStatus unknownNCT03900169
• Safety and Tolerability Study of Ezetimibe (SCH 058235/MK-0653) Plus Atorvastatin or Simvastatin in Homozygous Familial Hypercholesterolemia (P01417/MK-0653-019)CompletedNCT03885921Phase 3
• Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018)CompletedNCT03884452Phase 3
• Comparison of the Plasma Lipoprotein Apheresis Systems DIAMED and MONET vs. the Whole Blood Apheresis System DALICompletedNCT03795038Not applicable
• Cross-over Pilot Study of Blood Cholesterol Response to Dietary Saturated Fat in Patients With Autosomal Dominant HypercholesterolemiaWithdrawnNCT03756779Not applicable
• Study of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic PatientsCompletedNCT03747224Phase 1
• Return of Actionable Variants Empirical StudyCompletedNCT03640234
• Genetic Causes of Hypercholesterolaemia in the Emirati PopulationStatus unknownNCT03597958
• Effects of Soy Protein on Cholesterol Levels in Children Affected With Familial HypercholesterolemiaCompletedNCT03563547Not applicable
• Prevalence of Familial Hypercholesterolaemia (FH) in Italian Patients With Coronary Artery DiseaseCompletedNCT03520140
• Study of Coronary Calcification in Subjects With Autosomal Dominant Familial Hypercholesterolemia HeterozygousCompletedNCT03501875Not applicable
• Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)WithdrawnNCT03455777Phase 2
• a Prospective Pilot Study of Screening Out Rate and Clinical Management of Familial HypercholesterolemiaStatus unknownNCT03398954
• Aortic Stenosis in Subjects With Heterozygous Familial Hypercholesterolemia on Prolonged Treatment With StatinsStatus unknownNCT03310671
• IN-TANDEM Familial Hypercholesterolemia Pilot StudyCompletedNCT03253432
• Study of cardiovAscular Contrasted Phenotypes in Patients With FamIliaI hypercholesteRolemiaCompletedNCT03234127Not applicable
• Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH)WithdrawnNCT03198897
• A Registration Study for Familial Hypercholesterolemia in TaiwanStatus unknownNCT03152656
• Greek Registry - Familial HypercholesterolaemiaCompletedNCT03140605
• HDL Acute Lipid Optimization in Homozygous Familial HypercholesterolemiaStatus unknownNCT03135184Not applicable
• Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication RegistryCompletedNCT03110432
• Familial Hypercholesterolemia in Turkey (A-HIT2)CompletedNCT03110250
• Screening Protocol for a Gene Therapy Trial in Subjects With Homozygous Familial HypercholesterolemiaCompletedNCT03018678
• Lp(a) and Aortic Valve CalcificationCompletedNCT02976818
• Familial Hypercholesterolemia Amongst Patients With Acute Coronary SyndromeStatus unknownNCT02870660
• Developing and Implementing Familial Hypercholesterolemia RegistryStatus unknownNCT02865694
• Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in JapanCompletedNCT02808403
• Detection of Familial Hypercholesterolaemia in Cardiovascular Disease RegistryCompletedNCT02778646

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