An observational study in Aortic Stenosis, Arteriosclerosis and Familial Hypercholesterolemia, sponsored by Instituto Aragones de Ciencias de la Salud. Status unknown at 1 site in Spain. Open to participants aged 55 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-16.
Sponsored by Instituto Aragones de Ciencias de la Salud · Observational
Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterolemia, diabetes mellitus and arterial hypertension, the classic risk factors for the development of atherosclerosis. However, lipid-lowering therapy with statins and ezetimibe has not been shown to reduce the risk of long-term progression of AE by unknown mechanisms. All this suggests that subjects with HFhe have a high risk of developing AD, which has not been shown by the high coronary mortality in this population that precedes aortic calcification
The study includes a single clinical visit with collection of clinical data, blood extraction and the performance of a transthoracic echocardiogram. This visit may be made on different days, but always within 30 days of signing the informed consent.
1,025 studies on the registry are indexed under Aortic Valve Stenosis; 293 are open to participants now.
This study's planned enrollment of 900 is above the median of 200 across 435 observational studies indexed under Aortic Valve Stenosis.
Browse Aortic Valve Stenosis studies →Instituto Aragones de Ciencias de la Salud is the lead sponsor of 11 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Genetically diagnosed HFH or in a first-degree relative
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Cases:
Controls:
Exclusion Criteria:
Cases: * Age ≥ 65 years at the time of cardiac ultrasound * Genetically diagnosed HFH or in a first-degree relative * History of hypercholesterolemia with LDLc levels\> 220 mg / dL without lipid-lowering treatment
Procedure: Echocardiogram
* Genetically Similar * Siblings of the normocholesterolemic case, defined by LDLc \<190 mg / dl without lipid-lowering treatment. * In the absence of available siblings, first cousins may be included. * In the presence of several siblings available, the same sex will be included, * Environmentally similar * Stable partner of the case with cohabitation\> 25 years
Procedure: Echocardiogram
Conventional transthoracic echocardiogram by an echocardiographer trained to perform and centered on aortic valve Pick up from: * Mean transvalvular pressure gradient * Aortic valve * Aortic valve opening area * Aortic valve opening area adjusted for body mass index * Bicuspid or tricuspid aorta * Thickness of the upper valve\> 3 mm
Differences in age-adjusted prevalence of EA assessed by transthoracic echocardiography between cases and controls
Time frame: 1 YEAR
Differences in age-adjusted prevalence of AD assessed by transthoracic echocardiography between cases and controls
Time frame: 1 YEAR
Difference in aortic surface between cases and controls
Time frame: 1 YEAR
Difference in the mean transvalvular gradient between cases and controls
Time frame: 1 YEAR
Difference between maximum aortic jet velocity between cases and controls
Time frame: 1 YEAR
Plan to share: No
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This study is status unknown, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.
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Instituto Aragones de Ciencias de la Salud