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Not yet recruitingNCT07807969AiiM OLEUpdated Sep 8, 2026

An Open-label Extension Study of the Long-Term Safety of Vonaprument (ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)

A Phase 3 interventional study of Vonaprument in Geographic Atrophy, sponsored by Annexon, Inc.. Not yet recruiting at 7 sites in United States. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-09-08.

Sponsored by Annexon, Inc. · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
605
Allocation
Not applicable
Ages
50 Years and older
Sex
All
01

Study summary

The primary purpose of the study is to assess the long term safety of intravitreal (IVT) injections of vonaprument.

02

Conditions studied

  • Geographic Atrophy

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03

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Participants with a diagnosis of dry AMD with GA who completed the Phase 3 ARCHER II study (NCT06510816) and who had not permanently ceased receiving the assigned masked treatment (IVT or Sham administration) at/before the ARCHER II Month 24 Visit.

Exclusion criteria

Exclusion Criteria:

  • Any event or condition arising during the ARCHER II study that would put the participant in danger or lead to undue harm by participating in this OLE study.
04

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
605 participants (estimated)

Study arms

  • Experimental
    Vonaprument

    Participants will receive vonaprument IVT injections every month for 24 months.

    Drug: Vonaprument

Interventions

  • DrugVonaprument

    Form: solution for injection; Route of Administration: IVT injection

    Also known as: ANX007

05

What researchers measure

Primary outcomes

  1. Number of Participants with Treatment Emergent Adverse Events

    Time frame: Through Month 24

06

Study locations

7 sites
  • Retina Group of Florida
    Sarasota, Florida 34233, United States
  • Retina Vitreous Associates of Florida
    St. Petersburg, Florida 33711, United States
  • Cumberland Valley Retina Consultants
    Hagerstown, Maryland 21740, United States
  • Mid Atlantic Retina Specialists
    Hagerstown, Maryland 21740, United States
  • Retina Research Institute at New England Retina Consultants
    Springfield, Massachusetts 01107, United States
  • Asheville Eye Associates - Retina Division
    Asheville, North Carolina 28803, United States
  • Verum Research, LLC
    Eugene, Oregon 97401, United States
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07807969
Lead sponsor
Annexon, Inc.
Responsible party
Sponsor
First posted
Sep 8, 2026
Start date
Sep 30, 2026 (estimated)
Primary completion
Jul 31, 2029 (estimated)
Completion
Jul 31, 2029 (estimated)
Last update
Sep 8, 2026

Study contacts

Study Coordinator
Contact
clinicaltrials@annexonbio.com
650-822-5500
Clinical Trials
study director · Annexon, Inc.

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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