Epilepsies, Myoclonic clinical trials
The registry lists 92 studies for Epilepsies, Myoclonic across more than 10 countries. 21 are recruiting or about to start. 71 of them are mainly about Epilepsies, Myoclonic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Who runs them
Takeda (7) · Jazz Pharmaceuticals (7) · Longboard Pharmaceuticals (5) · Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc. (5) · Encoded Therapeutics (4) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Gillette Children's Specialty Healthcare (3) · University of Colorado, Denver (3)
What is being tested here
Drugs under test in Epilepsies, Myoclonic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fenfluramine | 2 | 7 | 11 |
| Cannabidiol | 1 | 8 | 14 |
| Bexicaserin | 1 | 2 | 4 |
| ETX101 | 1 | 0 | 3 |
| Clemizole hydrochloride | 1 | 1 | 2 |
| Glycerol phenylbutyrate | 1 | 0 | 1 |
| BMB-101 | 1 | 0 | 1 |
| Soticlestat | 0 | 3 | 5 |
| Zorevunersen | 0 | 1 | 3 |
| Cysteamine | 0 | 0 | 2 |
Drug classes tested here Serotonin receptor agonists 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS) · Phase 3 · Longboard Pharmaceuticals
- Mar 2027A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome · Phase 3 · Stoke Therapeutics, Inc
- Apr 2027A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome · Phase 3 · Epygenix
- Nov 2027A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE) · Phase 3 · Longboard Pharmaceuticals
- Nov 2026Early Check: Expanded Screening in Newborns · RTI International
- Dec 2026Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age · University of Colorado, Denver
- Jan 2027CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut Syndrome · Alexander Rotenberg
- Jan 2027Observational Study in Patients With Cyclin-dependent Kinase-like 5 Deficiency Disorder · Loulou Foundation
- Feb 2027Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY · Jazz Pharmaceuticals
- Aug 2027Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution · Jazz Pharmaceuticals
Who these studies take
Of the 14 Epilepsies, Myoclonic studies recruiting now, 3 (21%) set no upper age limit and 10 (71%) stop at 75 or younger. 11 (79%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (21%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 9 (64%) | 9 (64%) |
| 18 | 10 (71%) | 10 (71%) |
| 30 | 7 (50%) | 7 (50%) |
| 40 | 7 (50%) | 7 (50%) |
| 50 | 7 (50%) | 7 (50%) |
| 65 | 5 (36%) | 5 (36%) |
| 75 | 4 (29%) | 4 (29%) |
| 85 | 4 (29%) | 4 (29%) |
Across all 92 studies, recruiting or not: 70% stop at 75 or younger and 67% at 65; 90% take children; 1% are for women only and 0% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Epilepsies, Myoclonic studies take
Of 15 phase 3 interventional studies under Epilepsies, Myoclonic, half reached primary completion within 35 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 35 mo27–72 · 15 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 92. Browse all 92 → or search them.
- ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet SyndromeRecruitingNCT07531745Phase 1/22 countries
- A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet SyndromeRecruitingNCT04462770Phase 311 countries
- A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet SyndromeRecruitingNCT05419492Phase 1/23 countries
- A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)Enrolling by invitationNCT06908226Phase 317 countries
- Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGSEnrolling by invitationNCT07225231Not applicable1 country
- A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related DisordersRecruitingNCT07847918Phase 21 country
- A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to EpidiolexNot yet recruitingNCT06924827Phase 41 country
- Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet SyndromeNot yet recruitingNCT078014041 country
- The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome ProjectRecruitingNCT07112365Phase 41 country
- A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet SyndromeRecruitingNCT07675746Early Phase 11 country
- Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24 Months of AgeRecruitingNCT06598449Phase 41 country
- A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet SyndromeRecruitingNCT07013331Not applicable1 country
- Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and AdolescentsRecruitingNCT051269141 country
- Longitudinal Study of Phenotypic and Developmental Severity in Patients With Dravet Syndrome With SCN1A Gene MutationRecruitingNCT072516731 country
- BMB-101 in Absence Epilepsy and DEERecruitingNCT06401538Phase 21 country
- Intermediate-Size Expanded Access Protocol (EAP) for LP352AvailableNCT061496632 countries
- CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut SyndromeNot yet recruitingNCT06738732Phase 1/21 country
- SCN1A Horizons A Natural History Study of SCN1A-related Epilepsies in the United KingdomRecruitingNCT065045111 country
- Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research InitiativesRecruitingNCT056352661 country
- EXploring novEl Molecular Determinants of DRAvet Syndrome Phenotype HeterogeneityEnrolling by invitationNCT06371794Not applicable1 country
- GABA Biomarkers in Dravet SyndromeRecruitingNCT056512041 country
- A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)Active, not recruitingNCT06660394Phase 318 countries
- A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet SyndromeActive, not recruitingNCT06872125Phase 38 countries
- Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory EpilepsiesNo longer availableNCT044576872 countries
- A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet SyndromeCompletedNCT06118255Phase 35 countries
- A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic EncephalopathiesCompletedNCT03650452Phase 28 countries
- A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut SyndromeTerminatedNCT05163314Phase 320 countries
- A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to FenfluramineTerminatedNCT06422377Phase 31 country
- A Study of Soticlestat in Adults and Children With Rare EpilepsiesTerminatedNCT03635073Phase 28 countries
- A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet SyndromeCompletedNCT04940624Phase 318 countries
- Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral SolutionActive, not recruitingNCT05044819Phase 41 country
- A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in SpainCompletedNCT059827171 country
- A Study on Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) in Children, Teenagers and Adults in PortugalWithdrawnNCT06395792
- Early Check: Expanded Screening in NewbornsActive, not recruitingNCT036552231 country
- The Becoming of Children With Doose SyndromeCompletedNCT040482131 country
- A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet SyndromeActive, not recruitingNCT06283212Phase 1/21 country
- Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALYActive, not recruitingNCT054858311 country
- Applicability and Effectiveness of Remote Occupational TherapyCompletedNCT075926501 country
- Fenfluramine for Adult Dravet PatientsTerminatedNCT05560282Phase 31 country
- International CDKL5 RegistrySuspendedNCT044867681 country
- Treatment of Dravet Syndrome With Fenfluramine (Expanded Access Protocol)Approved for marketingNCT044370041 country
- An Open-Label Extension Study of STK-001 for Patients With Dravet SyndromeActive, not recruitingNCT04740476Phase 21 country
- Treatment Plan to Provide Expanded Access to Stiripentol for Patients With Dravet SyndromeApproved for marketingNCT019837221 country
- Neurodevelopmental Impact of Epilepsy on Autonomic Function in Dravet SyndromeActive, not recruitingNCT05472389Not applicable3 countries
- Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic EncephalopathyCompletedNCT05626634Phase 22 countries
- A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut SyndromeCompletedNCT03936777Phase 314 countries
- A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome (Australia Only)Active, not recruitingNCT06112275Phase 1/21 country
- Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled SeizuresTerminatedNCT04485104Phase 33 countries
- A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet SyndromeTerminatedNCT04572243Phase 32 countries
- Bioavailability of Stiripentol After Single Oral Dose of Capsule vs Suspension in Healthy Subjects (STILIQ)CompletedNCT07176832Phase 11 country