Diabetic Cardiomyopathies clinical trials
The registry lists 30 studies for Diabetic Cardiomyopathies across more than 10 countries. 9 are recruiting or about to start. 14 of them are mainly about Diabetic Cardiomyopathies (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Who runs them
University of Texas Southwestern Medical Center (3) · University of Roma La Sapienza (2) · Washington University School of Medicine (2) · University of Louisville (1) · Slagelse Hospital (1) · Centre Hospitalier Universitaire de Nice (1) · University Hospital, Strasbourg, France (1) · Applied Therapeutics, Inc. (1)
What is being tested here
Drugs under test in Diabetic Cardiomyopathies studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Caficrestat | 0 | 1 | 1 |
| Grapiprant | 0 | 1 | 1 |
| Dapagliflozin | 0 | 0 | 1 |
| Ninerafaxstat | 0 | 0 | 1 |
| Tadalafil | 0 | 0 | 1 |
| Fenofibrate | 0 | 0 | 1 |
| Trimetazidine | 0 | 0 | 1 |
| Perhexiline | 0 | 0 | 1 |
| Probiotic | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4, phase 3 first
- Dec 2026Tailored Exercise Training Study Among Adults With HFpEF · Phase 3 · University of Texas Southwestern Medical Center
- Dec 2026CMR in T2DM: The NSR Cohort · Slagelse Hospital
- Sep 2027Polypill for Prevention of Cardiomyopathy · University of Texas Southwestern Medical Center
- Oct 2027Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications · Assiut University
Who these studies take
Of the 6 Diabetic Cardiomyopathies studies recruiting now, 3 (50%) set no upper age limit and 1 (17%) stop at 75 or younger. 1 (17%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (17%) | 1 (17%) |
| 18 | 3 (50%) | 3 (50%) |
| 30 | 5 (83%) | 5 (83%) |
| 40 | 5 (83%) | 5 (83%) |
| 50 | 6 (100%) | 6 (100%) |
| 65 | 6 (100%) | 6 (100%) |
| 75 | 6 (100%) | 6 (100%) |
| 85 | 5 (83%) | 5 (83%) |
Across all 30 studies, recruiting or not: 33% stop at 75 or younger and 17% at 65; 7% take children; 0% are for women only and 0% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesNov 2, 2026NCT07911007
Studies
Recruiting first, then most recently updated. Showing 30 of 30. search them.
- Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 DiabetesRecruitingNCT07911007Not applicable1 country
- Soluble TREM-1 in Diabetes-Associated Cardiovascular ComplicationsNot yet recruitingNCT07847112
- NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM StudyRecruitingNCT06593327Not applicable1 country
- Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean Patients With Type 2 DiabetesNot yet recruitingNCT077707371 country
- Polypill for Prevention of CardiomyopathyRecruitingNCT06143566Phase 1/21 country
- Mitochondrial Substrate Utilization in the Diabetic Human HeartRecruitingNCT059587061 country
- Tailored Exercise Training Study Among Adults With HFpEFRecruitingNCT07223242Phase 2/31 country
- Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes MellitusRecruitingNCT031321291 country
- CMR in T2DM: The NSR CohortEnrolling by invitationNCT059152601 country
- The DAPA-MEMRI TrialCompletedNCT04591639Not applicable1 country
- CARdiomyopathy in Type 2 DIAbetes MellitusActive, not recruitingNCT043033645 countries
- Premature Aging and Type 2 Diabetes Mellitus: an Increased Risk of Cardiomyopathy?CompletedNCT01536808Not applicable1 country
- IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)CompletedNCT04826159Phase 21 country
- Diabetic Cardiomyopathy and Heart FailureWithdrawnNCT05571865Not applicable1 country
- Evaluation of Alpha-Lipoic Acid in Diabetic CardiomyopathyTerminatedNCT04141475Not applicable1 country
- Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass SurgeryCompletedNCT010672091 country
- Safety and Efficacy of AT-001 in Patients With Diabetic CardiomyopathyActive, not recruitingNCT04083339Phase 310 countries
- Efficacy of Trimetazidine in Diabetic PatientsStatus unknownNCT05556005Phase 21 country
- Impact of Prediabetes on Acute Coronary SyndromeCompletedNCT051028511 country
- Diabetic CardiomyopathyStatus unknownNCT045931731 country
- Effect of High-intensity Interval Training on Cardiac Function and Regulation of Glycemic Control in Diabetic CardiomyopathyCompletedNCT03299790Not applicable1 country
- In and ex Vivo Mitochondrial Function of the HeartCompletedNCT030492281 country
- Single-center Clinical Study of Early Diagnosis of Diabetic Cardiomyopathy With FLIMStatus unknownNCT04534894
- Preclinical Cardiomyopathy and Autonomic Function in Type 1 DiabetesCompletedNCT039300041 country
- REmodelling in Diabetic CardiOmapathy: Gender Response to PDE5i InhibiTOrsCompletedNCT01803828Phase 41 country
- Assessment of Myocardial Injury in Simultaneous Pancreas and Kidney TransplantationStatus unknownNCT039044851 country
- Lipid Biomarkers for Diabetic Heart DiseaseCompletedNCT01752842Not applicable1 country
- Impact of Pharmacist in Cardiology ServiceCompletedNCT03206294Not applicable1 country
- Pilot Study to Assess the Proteome in Human Atrial TissueCompletedNCT005919031 country
- Mechanisms Responsible for Cardiac and Skeletal Muscle Energetic Impairment in DiabetesStatus unknownNCT00628056Phase 1/21 country