Carcinoma, Merkel Cell clinical trials
The registry lists 150 studies for Carcinoma, Merkel Cell across more than 10 countries. 40 are recruiting or about to start. 67 of them are mainly about Carcinoma, Merkel Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
National Cancer Institute (NCI) (11) · Memorial Sloan Kettering Cancer Center (5) · Incyte Corporation (4) · H. Lee Moffitt Cancer Center and Research Institute (4) · Fate Therapeutics (4) · Incyte Biosciences International Sàrl (4) · ImmunityBio, Inc. (4) · Fred Hutchinson Cancer Center (4)
What is being tested here
Drugs under test in Carcinoma, Merkel Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Immune checkpoint inhibitors 10 open · mTOR inhibitors 1 open · Tyrosine kinase inhibitors (TKIs) 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Testing Pembrolizumab Versus Observation in Patients With Merkel Cell Carcinoma After Surgery, STAMP Trial · Phase 3 · National Cancer Institute (NCI)
- Mar 2027Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma · Phase 3 · TuHURA Biosciences, Inc.
- Nov 2026Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma · Melanoma and Skin Cancer Trials Limited
- Dec 2026A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma · Fujifilm Pharmaceuticals U.S.A., Inc.
- Dec 2026Targeted Therapy and Avelumab in Merkel Cell Carcinoma · Melanoma and Skin Cancer Trials Limited
- Dec 2026Neoadjuvant Nivolumab and Relatlimab in Merkel Cell Carcinoma · Melanoma Institute Australia
- Dec 2026French National Database of Rare Dermatological Cancers · University Hospital, Lille
- Dec 2026Neoadjuvant PD-1 Blockade in Resectable Merkel Cell Carcinoma · Abramson Cancer Center at Penn Medicine
- Jan 2027In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors · University of Southern California
- Jan 2027Triple Immune Checkpoint Inhibition for Advanced or Metastatic PD-(L)1 Refractory Merkel Cell Carcinoma · University of Washington
Who these studies take
Of the 34 Carcinoma, Merkel Cell studies recruiting now, 27 (79%) set no upper age limit and 0 (0%) stop at 75 or younger. 5 (15%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (3%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (12%) | 4 (12%) |
| 18 | 34 (100%) | 34 (100%) |
| 30 | 34 (100%) | 34 (100%) |
| 40 | 34 (100%) | 34 (100%) |
| 50 | 34 (100%) | 34 (100%) |
| 65 | 34 (100%) | 34 (100%) |
| 75 | 34 (100%) | 34 (100%) |
| 85 | 34 (100%) | 34 (100%) |
Across all 150 studies, recruiting or not: 2% stop at 75 or younger and 0% at 65; 5% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Carcinoma, Merkel Cell studies take
Of 33 phase 2 interventional studies under Carcinoma, Merkel Cell, half reached primary completion within 92 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 47 mo36–60 · 25 studies | — | — |
| Phase 2 | 92 mo47–138 · 33 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 150. Browse all 150 → or search them.
- Studies of Dermatologic Diseases Biospecimen Acquisition ProtocolRecruitingNCT024713521 country
- Neoadjuvant Merkel Cell Carcinoma Therapy (Tx) With the PD-1 Inhibitor CemiplimabRecruitingNCT07387198Phase 21 country
- ASTX727 & Retifanlimab-dlwr for Advanced Merkel Cell After Progression on Anti-PD-(L)1Not yet recruitingNCT07472322Phase 1/21 country
- IFx-Hu2.0 As An Adjunctive Therapy To Pembrolizumab In Advanced Or Metastatic Merkel Cell Carcinoma (MCC)RecruitingNCT06940440Phase 11 country
- Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin CancerRecruitingNCT05896839Phase 1/21 country
- A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid TumorsRecruitingNCT07749586Phase 1/21 country
- A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid TumorsRecruitingNCT07115043Phase 1/24 countries
- Personalised Immunotherapy PlatformRecruitingNCT065362571 country
- Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing TumorsRecruitingNCT06814496Phase 1/21 country
- The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding AreasRecruitingNCT07285044Phase 21 country
- Phase II Study of Peptide Receptor Radionuclide Therapy in Combination With Immunotherapy for Patients With Merkel Cell CancerRecruitingNCT05583708Phase 21 country
- Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain MetastasisRecruitingNCT06047379Phase 1/21 country
- Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid TumorsRecruitingNCT07006727Phase 14 countries
- A Study of CRD3874-SI in People With Solid TumorsRecruitingNCT06021626Phase 11 country
- Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic CancerRecruitingNCT05267626Phase 1/22 countries
- Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO TrialNot yet recruitingNCT07576725Phase 21 country
- Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC VirusRecruitingNCT02479698Phase 21 country
- Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid TumorsRecruitingNCT05269381Phase 1/21 country
- A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor CancerRecruitingNCT05859074Phase 11 country
- A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid TumorsRecruitingNCT05592626Phase 1/24 countries
- Hypofractionated Radiation Therapy for Merkel Cell CarcinomaRecruitingNCT05100095Phase 21 country
- A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21)RecruitingNCT07302347Phase 1/21 country
- Neoadjuvant Cemiplimab in Newly Diagnosed or Recurrent Stage I-II Merkel Cell Carcinoma and Locoregionally Advanced Cutaneous Squamous Cell CarcinomaRecruitingNCT04975152Phase 11 country
- Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational StudyRecruitingNCT072159881 country
- MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid TumorsRecruitingNCT05076760Phase 11 country
- French National Database of Rare Dermatological CancersRecruitingNCT032109351 country
- Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell CarcinomaRecruitingNCT06947928Phase 2/31 country
- Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any HistotypeRecruitingNCT06753136Not applicable1 country
- EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin CancersRecruitingNCT06223659Phase 21 country
- Neoadjuvant PD-1 Blockade in Resectable Merkel Cell CarcinomaRecruitingNCT05496036Phase 21 country
- Neoadjuvant Nivolumab and Relatlimab in Merkel Cell CarcinomaRecruitingNCT06151236Phase 21 country
- TIL Therapy in cSCC and MCCRecruitingNCT07288073Phase 21 country
- Validation of in Vitro Method for Anti-MCPyV Immunotherapy on Patients With Cutaneous Merkel Cell CarcinomaRecruitingNCT067804751 country
- Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal CancersRecruitingNCT057974151 country
- IFx-Hu2.0 Expanded Access ProgramAvailableNCT04853602
- Identification and Characterization of Circulating Tumor Cells Before and After Treatment (Surgery and Radiotherapy) in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell CarcinomaNot yet recruitingNCT06448611
- Study of PembrolizumAb combiNeD With Cisplatin or carbOplatin and Etoposide in Treatment naïve Advanced meRkel Cell cArcinoma (MCC)Not yet recruitingNCT06086288Phase 21 country
- L19IL2/L19TNF in Skin Cancer PatientsRecruitingNCT05329792Phase 23 countries
- Exploring Merkel Cell Carcinoma Clinical Trial Engagement PatternsNot yet recruitingNCT060390331 country
- Navtemadlin (KRT-232) With or Without Anti-PD-1/Anti-PD-L1 for the Treatment of Patients With Merkel Cell CarcinomaRecruitingNCT03787602Phase 1/210 countries
- Testing Pembrolizumab Versus Observation in Patients With Merkel Cell Carcinoma After Surgery, STAMP TrialActive, not recruitingNCT03712605Phase 31 country
- Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin CancersActive, not recruitingNCT02978625Phase 21 country
- A Beta-only IL-2 ImmunoTherapY StudyActive, not recruitingNCT05086692Phase 1/28 countries
- Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic CancersActive, not recruitingNCT03816332Phase 11 country
- Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell CarcinomaActive, not recruitingNCT04291885Phase 22 countries
- Exercise to Boost Response to Checkpoint Blockade ImmunotherapyActive, not recruitingNCT05358938Early Phase 11 country
- Atezolizumab and Bevacizumab in Treating Patients With Rare Solid TumorsActive, not recruitingNCT03074513Phase 21 country
- A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell CarcinomaActive, not recruitingNCT04047251Phase 11 country
- A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid TumorsCompletedNCT05864144Phase 1/21 country
- Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell CarcinomaCompletedNCT03304639Phase 21 country