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Not yet recruitingNCT07877220Updated Oct 16, 2026

Estimating The Rate Of Complete Ablation (A0) With The Use Of Biomechanical Deformable Image Registration

An interventional study of RayAblation in Liver Tumors, sponsored by M.D. Anderson Cancer Center. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.

Sponsored by M.D. Anderson Cancer Center · Not applicable, Interventional, and Treatment

Updated Oct 16, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
200
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The goal of this research study is to find out if using an updated version of standard computer software (called RayStation) for confirming that thermal ablation treatment was able to destroy all tumor cells including a safety margin.

Read the detailed description

Primary Objective:

1. To estimate the A0 rate (≥5mm MAM) after percutaneous thermal ablation of malignant liver tumors achieved when using RayAblation intra-procedurally

Secondary Objectives:

  1. To evaluate the usability by the treating interventional radiologist on a System Usability Score questionnaire
  2. To evaluate the performance of the segmentation and registration algorithms within RayAblation
  3. To evaluate the complication rates related to the use of RayAblation .
02

Conditions studied

  • Liver Tumors

Keywords

  • Thermal Ablation
03

In context

Carcinoma, Hepatocellular

3,249 studies on the registry are indexed under Carcinoma, Hepatocellular; 974 are open to participants now.

This study's planned enrollment of 200 is above the median of 55 across 2,347 interventional studies indexed under Carcinoma, Hepatocellular.

Browse Carcinoma, Hepatocellular studies →

Lead sponsor

M.D. Anderson Cancer Center is the lead sponsor of 3,044 studies on the registry; 578 are open to participants now.

Of its 608 completed or terminated interventional studies of FDA-regulated products, 407 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Patients with primary or secondary liver tumors referred for percutaneous thermal liver ablation as per the standard of care
  2. ≤5 abatable tumors
  3. Each tumor measuring ≤5 cm in its largest dimension
  4. Ability to obtain a 5 mm MAM on pre- and intraprocedural CECT

Exclusion criteria

Exclusion Criteria:

  1. Age \<18 years old
  2. Currently breastfeeding or pregnant
  3. Unable to receive at least pre- and final post-ablation contrast-enhanced CT during the ablation procedure
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
200 participants (estimated)

Study arms

  • Experimental
    Patients treatment with RayAblation

    Participants will undergo standard-of-care thermal ablation as per institutional practice

    Device: RayAblation

Interventions

  • DeviceRayAblation

    AC software will be used at the end of the procedure to assess the ablation margins.

06

What researchers measure

Primary outcomes

  1. Safety and Adverse Events (AEs)

    Incidence of Adverse Events, Graded According to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version (v) 6.0

    Time frame: Through study completion; an average of 1 year

07

Study locations

1 site
  • UT MD Anderson
    Houston, Texas 77030, United States
08

References and documents

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 16, 2026
Show all 1 update
  1. Oct 16, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07877220
Collaborators
RaySearch Laboratories
Responsible party
Sponsor
First posted
Oct 16, 2026
Start date
Apr 1, 2027 (estimated)
Primary completion
Dec 31, 2027 (estimated)
Completion
Dec 31, 2029 (estimated)
Last update
Oct 16, 2026

Study contacts

Iwan Paolucci, PHD
Contact
ipaolucci@mdanderson.org
(713) 792-1846
Iwan Paolucci, PHD
principal investigator · UT MD Anderson

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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