Carcinoma, Adenoid Cystic clinical trials
The registry lists 86 studies for Carcinoma, Adenoid Cystic across more than 10 countries. 26 are recruiting or about to start. 55 of them are mainly about Carcinoma, Adenoid Cystic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13.
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Who runs them
Memorial Sloan Kettering Cancer Center (6) · Eye & ENT Hospital of Fudan University (5) · M.D. Anderson Cancer Center (4) · Dana-Farber Cancer Institute (4) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (4) · Radboud University Medical Center (3) · Hospices Civils de Lyon (2) · Heidelberg University (2)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 4 programmes from 4 companies, 2 with this as their studies’ main aim; 0 with a live phase 3 study; 0 primary completions in the next 12 months.
Stage, biomarker and line of therapy are not read yet: these programmes are in development here, not all in the same competitive position.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
None given by two companies or more yet.
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 4 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorised original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Carcinoma, Adenoid Cystic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 3 open · Immune checkpoint inhibitors 1 open · HDAC inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland Cancers · Memorial Sloan Kettering Cancer Center
- Dec 2026Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors · Hospices Civils de Lyon
- Dec 2026Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC · OncoC4, Inc.
- Dec 2026ADC and SBRT for Recurrent/Metastatic Salivary Gland Carcinoma · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- Feb 2027A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors · Day One Biopharmaceuticals, Inc.
- Mar 2027A Study of Enfortumab Vedotin in People With Adenoid Cystic Carcinoma · Memorial Sloan Kettering Cancer Center
- May 2027Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma · Memorial Sloan Kettering Cancer Center
- Jun 2027CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC · Michael J. Dennis, MD
- Jul 2027Agnostic Therapy in Rare Solid Tumors · Instituto do Cancer do Estado de São Paulo
- Jul 2027A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers · Dana-Farber Cancer Institute
Who these studies take
Of the 23 Carcinoma, Adenoid Cystic studies recruiting now, 15 (65%) set no upper age limit and 3 (13%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 23 (100%) | 23 (100%) |
| 30 | 23 (100%) | 23 (100%) |
| 40 | 23 (100%) | 23 (100%) |
| 50 | 23 (100%) | 23 (100%) |
| 65 | 23 (100%) | 23 (100%) |
| 75 | 22 (96%) | 22 (96%) |
| 85 | 17 (74%) | 17 (74%) |
Across all 86 studies, recruiting or not: 12% stop at 75 or younger and 1% at 65; 1% take children; 0% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Carcinoma, Adenoid Cystic studies take
Of 28 phase 2 interventional studies under Carcinoma, Adenoid Cystic, half reached primary completion within 43 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 43 mo32–67 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting3
- SPARE-1st: Surgery Alone vs Surgery Plus Postoperative Radiotherapy for Sinonasal Adenoid Cystic CarcinomaNov 3, 2026NCT07563088
- Neoadjuvant Anlotinib and Epirubicin for T4 Sinonasal Adenoid Cystic CarcinomaNov 3, 2026NCT07616141
- Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate CancerOct 15, 2026NCT07667400
Studies
Recruiting first, then most recently updated. Showing 50 of 86. Browse all 86 → or search them.
- A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-KitRecruitingNCT06805825Phase 11 country
- Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate CancerRecruitingNCT07667400Phase 1/21 country
- SPARE-1st: Surgery Alone vs Surgery Plus Postoperative Radiotherapy for Sinonasal Adenoid Cystic CarcinomaRecruitingNCT075630881 country
- VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or LymphomaRecruitingNCT03556228Phase 1/22 countries
- Neoadjuvant Anlotinib and Epirubicin for T4 Sinonasal Adenoid Cystic CarcinomaRecruitingNCT07616141Phase 21 country
- Surgery Plus Postoperative Radiotherapy for T4 Sinonasal Adenoid Cystic CarcinomaRecruitingNCT076524891 country
- Phase II Trial of Puxitatug Samrotecan (AZD8205) in Advanced, Recurrent or Metastatic (R/M) Aggressive Adenoid Cystic Carcinoma Subtype I (ACC-I)RecruitingNCT07162480Phase 21 country
- A Phase 1 Study of LNCB74 in Advanced Solid TumorsRecruitingNCT06774963Phase 11 country
- A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland CancersRecruitingNCT06805617Phase 21 country
- Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR TrialRecruitingNCT04883671Not applicable1 country
- A Study of Enfortumab Vedotin in People With Adenoid Cystic CarcinomaRecruitingNCT06891560Phase 21 country
- Phase II Trial Comparing Stereotactic Body Radiotherapy Versus Active Surveillance for Oligometastatic Adenoid Cystic CarcinomaNot yet recruitingNCT07845097Phase 2
- Clinical Trial of HG146 Administered to Participants With Adenoid Cystic CarcinomaRecruitingNCT06781567Phase 21 country
- CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACCRecruitingNCT05774899Phase 1/21 country
- First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands TumorRecruitingNCT07755397Phase 11 country
- A Study of Becotatug Vedotin (MRG003) Combined With Epirubicin as Neoadjuvant Therapy for EGFR-Positive, Unresectable Recurrent Sinonasal Adenoid Cystic CarcinomaRecruitingNCT07522879Phase 21 country
- Sacituzumab Tirumotecan in Recurrent/Metastatic Adenoid Cystic Carcinoma and Papillary Thyroid Carcinoma (STRAP)Not yet recruitingNCT07521670Phase 24 countries
- A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid TumorsRecruitingNCT05377996Phase 1/21 country
- Study of REM-422 in Patients With Recurrent, Metastatic, or Unresectable Adenoid Cystic CarcinomaRecruitingNCT06118086Phase 1/22 countries
- Epirubicin Interventional Chemotherapy for Sinonasal Adenoid Cystic Carcinoma (SNACC): A Prospective StudyRecruitingNCT07320508Phase 21 country
- ADC and SBRT for Recurrent/Metastatic Salivary Gland CarcinomaNot yet recruitingNCT07579598Phase 2
- A Multi-omics Approach to Disclose Progression and Underlying Biology of Head and Neck Adenoid Cystic CarcinomaRecruitingNCT075075781 country
- Simultaneous Integrated Boost in Carbon Ion Radiotherapy for Head and Neck Adenoid Cystic CarcinomaRecruitingNCT05733910Not applicable1 country
- Adenoid Cystic Carcinoma and Carbon Ion Only IrradiationRecruitingNCT04214366Phase 21 country
- Tyrosine Kinase Inhibitors in Metastastic Adenoid Cystic CarcinomaRecruitingNCT04974866Phase 21 country
- Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant TumorsRecruitingNCT02838602Not applicable1 country
- 9-ING-41 Plus Carboplatin in Salivary Gland CarcinomaActive, not recruitingNCT05010629Phase 21 country
- Agnostic Therapy in Rare Solid TumorsActive, not recruitingNCT06638931Phase 21 country
- Lenvatinib and Pembrolizumab in People With Advanced Adenoid Cystic Carcinoma and Other Salivary Gland CancersActive, not recruitingNCT04209660Phase 21 country
- Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib MesylateCompletedNCT01046487Phase 11 country
- Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)Active, not recruitingNCT06462183Phase 12 countries
- Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLCActive, not recruitingNCT04140526Phase 1/22 countries
- A Study to Evaluate the Efficacy and Safety of Rivoceranib in Participants With Recurrent or Metastatic Adenoid Cystic Carcinoma (ACC)TerminatedNCT04119453Phase 22 countries
- APG-115 in Salivary Gland Cancer TrialActive, not recruitingNCT03781986Phase 1/21 country
- AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic CancerCompletedNCT04973683Phase 11 country
- Nivolumab and Ipilimumab in Treating Patients With Rare TumorsActive, not recruitingNCT02834013Phase 22 countries
- MC200708 Pemetrexed and Pembrolizumab for the Treatment of Recurrent and/or Metastatic Salivary Gland CancerActive, not recruitingNCT04895735Phase 21 country
- Testing Lenvatinib in Patients With Adenoid Cystic CarcinomaActive, not recruitingNCT02780310Phase 21 country
- Amivantamab in Adenoid Cystic CarcinomaActive, not recruitingNCT05074940Phase 21 country
- 177Lu-PSMA (177Lu-PNT2002) in PSMA-Positive Adenoid Cystic CarcinomaTerminatedNCT06322576Phase 21 country
- A Study of Felmetatug Vedotin/SGN-B7H4V in Advanced Solid TumorsTerminatedNCT05194072Phase 15 countries
- An Investigational Scan (Ga-68 PSMA-11 PET/CT) for the Detection of Therapy Response in Patients With Metastatic Adenoid Cystic CarcinomaCompletedNCT06521775Phase 21 country
- Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic CarcinomaCompletedNCT02098538Phase 21 country
- Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILECompletedNCT065359971 country
- PSMA-PET Imaging of Salivary Gland Tumours and Other Rare CancersCompletedNCT055819791 country
- A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal PassagesCompletedNCT03274414Phase 21 country
- Study of OBT076 Associated or Not in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma of the Head and NeckTerminatedNCT05930951Phase 11 country
- An Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK3326595 in Participants With Solid Tumors and Non-Hodgkin's LymphomaCompletedNCT02783300Phase 14 countries
- P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC)TerminatedNCT04249947Phase 11 country
- The Evaluation of the Effectiveness, Safety and Tolerability of Treatment, Using a PSMA-Lu177, in Patients with ACC- an Open, Non-commercial Clinical TrialWithdrawnNCT06199453Phase 21 country