Bulbo-Spinal Atrophy, X-Linked clinical trials
The registry lists 57 studies for Bulbo-Spinal Atrophy, X-Linked across more than 10 countries. 12 are recruiting or about to start. 22 of them are mainly about Bulbo-Spinal Atrophy, X-Linked (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Who runs them
Novartis Pharmaceuticals (6) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Assistance Publique - Hôpitaux de Paris (2) · AstraZeneca (2) · Accutar Biotechnology Inc (2) · NYU Langone Health (1) · Ramathibodi Hospital (1) · Janssen Pharmaceutical K.K. (1)
What is being tested here
Drugs under test in Bulbo-Spinal Atrophy, X-Linked studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Bicalutamide | 1 | 0 | 4 |
| Darolutamide | 1 | 0 | 2 |
| Tulmimetostat | 1 | 0 | 1 |
| Abiraterone | 1 | 0 | 1 |
| Abemaciclib | 1 | 0 | 1 |
| Mexiletine | 1 | 1 | 1 |
| Clenbuterol | 1 | 0 | 1 |
| Enzalutamide | 0 | 1 | 2 |
| Dezandrodeg | 0 | 1 | 1 |
| Ptvg-hp | 0 | 0 | 1 |
Drug classes tested here Antiandrogens 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Sep 2027A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer · Phase 3 · Celgene
- Nov 2026A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs · AstraZeneca
- Dec 2026International SBMA Project (KDA) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Dec 2026Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA) · National Institute of Neurological Disorders and Stroke (NINDS)
- Jun 2027A Placebo-controlled Study of Clenbuterol in Spinal and Bulbar Muscular Atrophy · Gianni Soraru
Who these studies take
Of the 12 Bulbo-Spinal Atrophy, X-Linked studies recruiting now, 5 (42%) set no upper age limit and 2 (17%) stop at 75 or younger. 3 (25%) take children under 18. 1 (8%) are for women only and 4 (33%) for men only; 2 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (25%) | 3 (25%) |
| 18 | 7 (58%) | 10 (83%) |
| 30 | 8 (67%) | 11 (92%) |
| 40 | 8 (67%) | 11 (92%) |
| 50 | 8 (67%) | 11 (92%) |
| 65 | 7 (58%) | 10 (83%) |
| 75 | 7 (58%) | 10 (83%) |
| 85 | 5 (42%) | 7 (58%) |
Across all 57 studies, recruiting or not: 16% stop at 75 or younger and 9% at 65; 16% take children; 12% are for women only and 54% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 57. Browse all 57 → or search them.
- A Study to Learn About the Investigational Drug Rinzimetostat (ORIC-944) in Patients With mCRPC Who Were Previously Treated With Abiraterone Acetate (Himalayas-1)RecruitingNCT07723248Phase 32 countries
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen InsensitivityRecruitingNCT047084311 country
- TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)RecruitingNCT07190300Phase 1/214 countries
- UK SMA Patient RegistryRecruitingNCT042925741 country
- Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)RecruitingNCT049449401 country
- ALS/MND Natural History Study Data RepositoryRecruitingNCT059660383 countries
- Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast CancerRecruitingNCT06365788Phase 21 country
- Clinical Trial of Mexiletine Hydrochloride for Spinal and Bulbar Muscular AtrophyRecruitingNCT06862596Phase 2/31 country
- A Placebo-controlled Study of Clenbuterol in Spinal and Bulbar Muscular AtrophyRecruitingNCT06169046Phase 21 country
- Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)RecruitingNCT05107349Not applicable1 country
- Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne VulgarisRecruitingNCT06108193Phase 1/21 country
- Patients With ALS and Other Motor Disorders Will be Treated With Umbilical or Placental Mesenchymal Cell Exosome SolutionCompletedNCT07105371Phase 12 countries
- A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer DrugsActive, not recruitingNCT07336446Phase 1/24 countries
- A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate CancerActive, not recruitingNCT06764485Phase 326 countries
- pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate CancerActive, not recruitingNCT04090528Phase 21 country
- Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical TrialsActive, not recruitingNCT05335876Phase 319 countries
- Specified Drug-Use Survey of Leuprorelin Acetate Injection Kit 11.25 mg "All-Case Investigation: Spinal and Bulbar Muscular Atrophy (SBMA)"CompletedNCT035555781 country
- Study to Evaluate Exicorilant (CORT125281) in Combination With Enzalutamide in Patients With Metastatic Castration-Resistant Prostate CancerTerminatedNCT03437941Phase 1/22 countries
- Darolutamide in Patients With Androgen Receptor-Positive Salivary Gland Carcinoma (DISCOVARY)CompletedNCT05694819Phase 21 country
- A Study of NIDO-361 in Patients With SBMACompletedNCT06411912Phase 24 countries
- International SBMA Project (KDA)Active, not recruitingNCT074434491 country
- Phase IIIb, Open-label, Multi-center Study to Evaluate Safety, Tolerability and Efficacy of OAV101 Administered Intrathecally to Participants With SMA Who Discontinued Treatment With Nusinersen or RisdiplamCompletedNCT05386680Phase 39 countries
- An Asian Study to Evaluate Efficacy and Safety of Oral Enzalutamide in Progressive Metastatic Prostate Cancer ParticipantsCompletedNCT02294461Phase 34 countries
- Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate CancerTerminatedNCT04926181Phase 21 country
- A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate CancerTerminatedNCT05241613Phase 11 country
- Androgen Deprivation Therapy in Advanced Salivary Gland CancerCompletedNCT01969578Phase 28 countries
- Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (OFELIA)CompletedNCT05073133Phase 42 countries
- Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA)CompletedNCT04851873Phase 39 countries
- A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Of AJ201 In PatientsCompletedNCT05517603Phase 1/21 country
- COVID-19 In-vitro Diagnostic Test and Androgen Receptor Gene ExpressionWithdrawnNCT045305001 country
- Efficacy Evaluation of Enobosarm Monotherapy in Treatment of AR+/ER+/HER2- Metastatic Breast CancerTerminatedNCT04869943Phase 34 countries
- A Study of AC176 for the Treatment of Metastatic Castration Resistant Prostate CancerTerminatedNCT05673109Phase 11 country
- Breast Cancer BRCA1 Carriers: a Pilot StudyWithdrawnNCT050621741 country
- Study of Hepatic Function in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT021240571 country
- The Effect of Androgen Receptor Polymorphism on Endometrial CancerStatus unknownNCT05157373
- Cabazitaxel in mCRPC Patients With AR-V7 Positive Circulating Tumor Cells (CTCs)Status unknownNCT03050866Phase 21 country
- Study to Compare Capsule and Liquid Formulations of Enzalutamide After Single Dose Administration Under Fasting Conditions in Prostate CancerTerminatedNCT03478904Phase 11 country
- AR, IGF-IR, IR and Peripheral Artery DiseaseStatus unknownNCT047101861 country
- Safety, Tolerability, and Efficacy of BVS857 in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT02024932Phase 24 countries
- A Safety Study of JNJ-56021927 in Participants With Metastatic Castration-Resistant Prostate CancerCompletedNCT02162836Phase 11 country
- Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)CompletedNCT035606611 country
- Effect of Functional Exercise in Patients With Spinal Bulbar Muscular AtrophyCompletedNCT01369901Phase 1/21 country
- MRI in Patients With Kennedy DiseaseCompletedNCT025013951 country
- Safety and Efficacy Studies of Panobinostat and Bicalutamide in Patients With Recurrent Prostate Cancer After CastrationCompletedNCT00878436Phase 1/21 country
- High Intensity Training in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT02156141Not applicable1 country
- Bicalutamide as A Treatment in AR-positive Metastatic Triple-Negative Breast Cancer (mTNBC) PatientsTerminatedNCT02348281Phase 21 country
- Bicalutamide Plus Aromatase Inhibitors in ER(+)/AR(+)/HER2(-) Metastatic Breast CancerStatus unknownNCT02910050Phase 21 country
- Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged WomenCompletedNCT019773131 country
- Effect of Goserelin (Zoladex®) in Spinal and Bulbar Muscular AtrophyCompletedNCT00851461Phase 41 country