ClinicalTrials.gg
RecruitingNCT02306200CHIPUpdated Apr 29, 2026

Cardiovascular Health Improvement Project

An observational study in Aortic Aneurysm, Aortic Dissection and Bicuspid Aortic Valve (BAV), sponsored by University of Michigan. Recruiting at 1 site in United States. Per ClinicalTrials.gov, last updated 2026-04-29.

Sponsored by University of Michigan · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
15,000
Sex
All
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Study summary

The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.

Read the detailed description

The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls. The aims of the study are to collect biological specimens (blood, plasma, serum, aortic tissue) and family history; establish a biobank, establish a comprehensive database with information from consented patients, and provide researchers with high quality well annotated DNA samples with demographic and clinical information.

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Conditions studied

  • Aortic Aneurysm
  • Aortic Dissection
  • Bicuspid Aortic Valve (BAV)
  • Heart Failure
  • Cardiovascular Diseases

Keywords

  • Aorta
  • Abdominal Aortic Aneurysm (AAA)
  • Thoracic Aortic Aneurysm (TAA)
  • Bicuspid Aortic Valve (BAV)
  • Aortic Dissection
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In context

Aortic Aneurysm

222 studies on the registry are indexed under Aortic Aneurysm; 63 are open to participants now.

This study's planned enrollment of 15,000 is above the median of 150 across 117 observational studies indexed under Aortic Aneurysm.

Browse Aortic Aneurysm studies →

Lead sponsor

University of Michigan is the lead sponsor of 1,506 studies on the registry; 192 are open to participants now.

Of its 169 completed or terminated interventional studies of FDA-regulated products, 133 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Outpatient clinic

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Any patient over the age of 18 who is able/willing to give
  • Patients \<18 years of age with parental consent and assent (if assent is applicable for their age)
  • Diagnosis of:
  • aortic pathology potentially due to a known or suspected inherited condition
  • Idiopathic aortic aneurysm
  • Interesting of novel vascular pathology in the aorta or main branches
  • Family history of aortic or vascular disease
  • Other cardiovascular disease
  • Healthy controls with no apparent cardiovascular disease

Exclusion criteria

Exclusion Criteria:

- Not willing or able to sign the consent

Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
15,000 participants (estimated)
Target follow-up
40 Years
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • Aortic Disease

    Patients with a diagnosis of any form of Aortic Disease

  • Controls

    Patients without a diagnosis of Aortic Disease

06

What researchers measure

Primary outcomes

  1. Establishing a biobank of patients with Aortic Disease

    Establish a biobank of blood, serum, plasma, tissue, and clinical data of patients with any form of aortic disease

    Time frame: 40 years

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Love-Nichols J, Uhlmann WR, Arscott P, Willer C, Hornsby W, Roberts JS. A survey of aortic disease biorepository participants' preferences for return of research genetic results. J Genet Couns. 2021 Jun;30(3):645-655. doi: 10.1002/jgc4.1341. Epub 2020 Dec 14. PubMed 33319384 ↗

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02306200
Responsible party
Marion Hofmann Bowman (Professor of Internal Medicine, University of Michigan) — Principal investigator
First posted
Dec 3, 2014
Start date
Aug 2013
Primary completion
Aug 2053 (estimated)
Completion
Aug 2053 (estimated)
Last update
Apr 29, 2026

Study contacts

Lauren Humphrey-Stark, BS
Contact
ljeany@med.umich.edu
7342324779
Jen McNamara, MS
Contact
jlmcnama@med.umich.edu
734-232-6180
Marion A Hofmann Bowman, PhD, MD
principal investigator · University of Michigan

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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