Axial Spondyloarthritis clinical trials
The registry lists 186 studies for Axial Spondyloarthritis across more than 10 countries. 56 are recruiting or about to start. 117 of them are mainly about Axial Spondyloarthritis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 2 narrower conditions too, such as Spondylitis, Ankylosing: 672 studies, 140 open.
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Status
Who runs them
AbbVie (8) · Novartis Pharmaceuticals (8) · Assistance Publique - Hôpitaux de Paris (7) · UCB Biopharma SRL (7) · Centre Hospitalier Universitaire de Besancon (4) · Biogen (3) · UCB BIOSCIENCES, Inc. (3) · Singapore General Hospital (3)
What is being tested here
Drugs under test in Axial Spondyloarthritis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Upadacitinib | 3 | 1 | 4 |
| Secukinumab | 1 | 5 | 8 |
| Bimekizumab | 1 | 3 | 4 |
| Tofacitinib | 1 | 1 | 3 |
| Vilamakitug | 1 | 0 | 1 |
| SCT650C | 1 | 0 | 1 |
| Baricitinib | 1 | 0 | 1 |
| Certolizumab Pegol | 0 | 2 | 5 |
| Adalimumab | 0 | 2 | 4 |
| Etanercept | 0 | 0 | 3 |
Drug classes tested here JAK inhibitors 5 open · Tyrosine kinase inhibitors (TKIs) 5 open · NSAIDs 5 · COX-2 inhibitors 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Sep 2027The Efficacy of Fecal Microbiota Transplatation on Axial Spondyloarthritis Patients Resistant to Conventional Treatment · Phase 3 · Assistance Publique - Hôpitaux de Paris
- Nov 2026Influence of Sodium Intake in spondyLoarthriTes · Centre Hospitalier Universitaire de Besancon
- Dec 2026Assessing the Feasibility of the Patient-Reported Outcomes Based Model for Community Care of Patients With Axial Spondyloarthritis Via a Type 1 Pilot Hybrid Effectiveness-Implementation Trial Using the RE-AIM Framework · Singapore General Hospital
- Dec 2026Efficacy of Non-invasive Vagus Nerve Stimulation for Axial Spondyloarthritis Resistant to Biotherapies · Assistance Publique - Hôpitaux de Paris
- Dec 2026High-intensity Training in Patients With Spondyloarthritis: a Randomized Controlled Trial · Halmstad University
- Dec 2026Exploratory Investigation of the Acceptance and Utility of 14-day Trial Periods and Application-related Outcome Measurement (AbEM) Within the Routine Prescription of the DiGA Axia. · Wuerzburg University Hospital
- Jan 2027Mediterranean Diet and Disease Activity in Axial Spondyloarthritis Receiving Biologic Therapy · Sinem Kübra Beke
- Mar 2027RENEW Intervention for Axial Spondyloarthritis · University of Michigan
- Mar 2027A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013) · Merck Sharp & Dohme LLC
- Apr 2027Physical Activity Through Health Technology in Axial Spondyloarthritis · University of Washington
Who these studies take
Of the 38 Axial Spondyloarthritis studies recruiting now, 20 (53%) set no upper age limit and 12 (32%) stop at 75 or younger. 5 (13%) take children under 18. 1 (3%) are for women only and 0 (0%) for men only; 3 (8%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (3%) | 1 (3%) |
| 18 | 35 (92%) | 34 (89%) |
| 30 | 37 (97%) | 36 (95%) |
| 40 | 37 (97%) | 36 (95%) |
| 50 | 36 (95%) | 35 (92%) |
| 65 | 34 (89%) | 33 (87%) |
| 75 | 27 (71%) | 26 (68%) |
| 85 | 22 (58%) | 21 (55%) |
Across all 186 studies, recruiting or not: 33% stop at 75 or younger and 27% at 65; 4% take children; 3% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Axial Spondyloarthritis studies take
Of 20 phase 3 interventional studies under Axial Spondyloarthritis, half reached primary completion within 32 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 32 mo21–39 · 20 studies | — | — |
| Interventional, no phase | 28 mo11–42 · 45 studies | — | 28 mo11–42 · 45 studies |
| Observational | 30 mo15–48 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
- RENEW Intervention for Axial SpondyloarthritisOct 29, 2026NCT07836374
Newly registered1
- Inspiratory Muscle Training in Axial SpondyloarthritisNov 3, 2026NCT07914439
Studies
Recruiting first, then most recently updated. Showing 50 of 186. Browse all 186 → or search them.
- Surface Topography and Radiographic Spinal Damage in Radiographic Axial SpondyloarthritisRecruitingNCT078553931 country
- EAST-1 (ERAP-inhibition in Axial Spondyloarthritis Trial - 1)RecruitingNCT07047703Phase 1/26 countries
- Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)RecruitingNCT07611747Phase 41 country
- A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in AdultsRecruitingNCT07290036Phase 16 countries
- RENEW Intervention for Axial SpondyloarthritisRecruitingNCT07836374Not applicable1 country
- A Pragmatic Trial of Interleukin-17 Inhibition Versus Janus Kinase Inhibition After Tumor Necrosis Factor-alpha Inhibitor Failure in Axial SpondyloarthritisNot yet recruitingNCT07770646Phase 41 country
- Evaluation of the Efficacy and Safety of Bimekizumab (BZK) or Adalimumab (ADA) in the Treatment of Anterior Chest Wall Pain Associated With Active Axial Spondyloarthritis Refractory to NSAIDs With Hypothesis of Superiority of BimekizumabNot yet recruitingNCT07836283Phase 31 country
- Effects of Land- and Water-Based Exercise in Axial SpondyloarthritisNot yet recruitingNCT07833033Not applicable1 country
- A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)RecruitingNCT06888193Phase 15 countries
- Postural Biofeedback and Exercise in Axial SpondyloarthritisNot yet recruitingNCT07776652Not applicable1 country
- Expanded Access to UpadacitinibAvailableNCT04159597
- Fecal Microbiota Transplantation in Axial SpondyloarthritisRecruitingNCT06451588Phase 21 country
- A Study to Assess the Safety of Subcutaneous Secukinumab for Treatment in Adult Indian Participants With Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS), and Non-Radiographic Axial Spondyloarthritis (nr-axSpA)Not yet recruitingNCT07737730
- Multicenter Validation of the 2025 Classification Criteria for Axial SpondyloarthritisRecruitingNCT077248471 country
- Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic DiseasesRecruitingNCT07087912Phase 41 country
- Physical Activity Through Health Technology in Axial SpondyloarthritisRecruitingNCT07642622Not applicable1 country
- Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for EfficacyNot yet recruitingNCT06526377Phase 2
- Effectiveness and Safety of Acemetacin in Active Axial Spondyloarthritis: A Real-world StudyNot yet recruitingNCT07582146Phase 41 country
- Exploratory Investigation of the Acceptance and Utility of 14-day Trial Periods and Application-related Outcome Measurement (AbEM) Within the Routine Prescription of the DiGA Axia.RecruitingNCT07561255Not applicable1 country
- The Disease Progression of Chinese Axial Spondyloarthritis in a Real-word Cohort StudyRecruitingNCT068446431 country
- A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic ArthritisRecruitingNCT06454188Phase 42 countries
- Fatigue and Skeletal Muscle Impact in Severe Axial SpondyloarthritisRecruitingNCT03940911Not applicable1 country
- Effect of a Self-Management Intervention for Patients Newly Diagnosed With Inflammatory Arthritis: The NISMA TrialRecruitingNCT06533423Not applicable1 country
- Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial SpondyloarthritisNot yet recruitingNCT07018206Phase 41 country
- Effects of Yoga Therapy in Rehabilitation Compared to Physiotherapy in Moderate Axial Spondyloarthritis (axSPA)RecruitingNCT06083090Not applicable1 country
- Spondyloarthritis Inception Cohort of Southern DenmarkEnrolling by invitationNCT06337513Not applicable1 country
- REDO-JAK: Dose Reduction of Janus Kinase Inhibitors in Patients With Inflammatory Rheumatic DiseasesRecruitingNCT07160231Phase 41 country
- Mediterranean Diet and Disease Activity in Axial Spondyloarthritis Receiving Biologic TherapyNot yet recruitingNCT07170384Not applicable1 country
- Initial Standardized Global Review in Axial SpondyloarthritisRecruitingNCT07141017Not applicable1 country
- Influence of Sodium Intake in spondyLoarthriTesRecruitingNCT06259890Not applicable1 country
- Exploring the Feasibility and Acceptability of Virtual Reality Exercise for Pain Management, Fear of Movement, Mobility, and Proprioception Deficit in Axial Spondyloarthritis Patients During Flares: Twics DesignNot yet recruitingNCT06967077Not applicable
- Assessing the Feasibility of the Patient-Reported Outcomes Based Model for Community Care of Patients With Axial Spondyloarthritis Via a Type 1 Pilot Hybrid Effectiveness-Implementation Trial Using the RE-AIM FrameworkNot yet recruitingNCT06968247Not applicable1 country
- Efficacy of Non-invasive Vagus Nerve Stimulation for Axial Spondyloarthritis Resistant to BiotherapiesNot yet recruitingNCT04286373Not applicable1 country
- A Study to Evaluate 608 in Patients With Non- Radiographic Axial Spondyloarthritis (Nr-axSpA)RecruitingNCT06222671Phase 21 country
- A LONGITUDINAL OBSERVATIONAL STUDY to EVALUATE the EFFICACY of MOVEMENT and IMPLEMENT CONCRETE MOVEMENT RECOMMENDATIONS with the HELP of MOBILITY TRACKING with SMARTWATCHES in SUBJECTS with AXIAL SPONDYLOARTHRITISRecruitingNCT068078531 country
- ToFAcitinib in Early Active Axial SpondyloarThritis:RecruitingNCT06112665Phase 41 country
- Factors for the Onset and Course of Axial SpondylitisRecruitingNCT065941071 country
- Osteosarcopenia in Axial SpondyloarthritisRecruitingNCT065773501 country
- Integration of Remote Monitoring in the Management of Chronic Immunosuppressive TherapyRecruitingNCT06544343Not applicable1 country
- Advanced Sensor Based Functional ASsessmenTs in Axial SpondyloarthritisRecruitingNCT044893421 country
- Barriers and Faciliators for Physical Activity in People With RMDsNot yet recruitingNCT06514443
- Active Pharmacovigilance Study of the Medicine Rinvoq™ (Upadacitinib)RecruitingNCT064981671 country
- axSEND: Exploring Immune and Microbiota Effects of a Partial Enteral Nutrition Diet in Axial SpondyloarthritisRecruitingNCT06460805Not applicable1 country
- The Efficacy of Fecal Microbiota Transplatation on Axial Spondyloarthritis Patients Resistant to Conventional TreatmentRecruitingNCT05654753Phase 2/31 country
- Severity Over Time of Early Forms of SpondyloarthritisNot yet recruitingNCT062619311 country
- Identification of New Biomarkers to Promote Personalized Treatment of Patients With Inflammatory Rheumatic DiseasesRecruitingNCT032142631 country
- Efficacy and Safety of SCT650C in Participants With Axial SpondyloarthritisNot yet recruitingNCT06197009Phase 21 country
- Clinical Trial of Electroacupuncture in Axial Spondyloarthritis (E-AcuSpA)RecruitingNCT04519866Not applicable1 country
- Baricitinib in the Treatment of Refractory Axial Spondyloarthritis Patients: A Comparison With TofacitinibRecruitingNCT06114407Phase 21 country
- The Effect of Aerobic Exercises and Yoga Exercises in Axial SpondyloarthritisRecruitingNCT06138717Not applicable1 country