Adenocarcinoma of Lung clinical trials
The registry lists 418 studies for Adenocarcinoma of Lung across more than 10 countries. 79 are recruiting or about to start. 195 of them are mainly about Adenocarcinoma of Lung (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its narrower condition Adenocarcinoma, Bronchiolo-Alveolar too: 428 studies, 79 open.
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Status
Who runs them
Alliance for Clinical Trials in Oncology (28) · National Cancer Institute (NCI) (25) · SWOG Cancer Research Network (15) · Novartis Pharmaceuticals (15) · Fudan University (12) · Shanghai Pulmonary Hospital, Shanghai, China (10) · Radiation Therapy Oncology Group (9) · Wake Forest University Health Sciences (8)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 5 programmes from 5 companies, 3 with this as their studies’ main aim; 0 with a live phase 3 study; 1 primary completion in the next 12 months.
Stage, biomarker and line of therapy are not read yet: these programmes are in development here, not all in the same competitive position.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
| Drug | Leading trial sponsor · rights | Companies, last 5 years |
|---|---|---|
pembrolizumabRecent, repeatedEvidence
| Merck & Co., Inc74% of its industry studiesUS: Merck & Co., Inc (FDA 2014)EU: Merck & Co., Inc (EMA 2015) | 33 studies |
CarboplatinRecent, repeatedPhase 4 trial recordedEvidence
| Eli Lilly and Company16% of its industry studies | 22 studies |
8 more in limited or earlier use — sign in to see them, free.
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 5 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (1)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
- 1 Jan 2027 est.SL-28 · Second Life Therapeutics · Phase 2 named, not the main aimNCT07341737 SL-28 for Advanced Solid Tumours — primary endpoint: Number of participants with treatment-emergent adverse events · 60 enrolled
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorised original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licences, line of therapy, academic comparators, sales.
What is being tested here
Drugs under test in Adenocarcinoma of Lung studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Aflutinib | 4 | 0 | 5 |
| Cisplatin | 2 | 2 | 15 |
| Pemetrexed | 2 | 2 | 13 |
| Tislelizumab | 2 | 0 | 4 |
| Carboplatin | 1 | 9 | 36 |
| Bevacizumab | 1 | 4 | 23 |
| Pembrolizumab | 1 | 0 | 3 |
| Anlotinib | 1 | 0 | 2 |
| Hydroxychloroquine | 1 | 0 | 2 |
| NW-301V | 1 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 7 open · Immune checkpoint inhibitors 5 open · Antimetabolites 3 open · Angiogenesis inhibitors 1 open · Antimitotic agents 48
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026Segmentectomy for Solid-dominant Lung Cancer · Phase 3 · Fudan University
- Mar 2027Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Small Cell Lung Cancer · Phase 3 · M.D. Anderson Cancer Center
- Nov 2026Pembrolizumab Plus Bevacizumab and Chemotherapy for ALK-rearranged NSCLC With Persistent 5'ALK · Hunan Province Tumor Hospital
- Dec 2026A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma · Lantern Pharma Inc.
- Dec 2026Pathogenic Variants in Genes Associated With Lung Adenocarcinoma · Oscar Gerardo Arrieta Rodríguez
- Dec 2026Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung Adenocarcinoma · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Dec 2026Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma · Fondazione del Piemonte per l'Oncologia
- Dec 2026Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) · SWOG Cancer Research Network
- Dec 2026Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer · Ohio State University Comprehensive Cancer Center
- Dec 2026Shared Decision Making in Patients With Lung Cancer · Sichuan Cancer Hospital and Research Institute
Who these studies take
Of the 58 Adenocarcinoma of Lung studies recruiting now, 36 (62%) set no upper age limit and 10 (17%) stop at 75 or younger. 4 (7%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (5%) | 3 (5%) |
| 18 | 51 (88%) | 51 (88%) |
| 30 | 58 (100%) | 58 (100%) |
| 40 | 58 (100%) | 58 (100%) |
| 50 | 58 (100%) | 58 (100%) |
| 65 | 58 (100%) | 58 (100%) |
| 75 | 54 (93%) | 54 (93%) |
| 85 | 41 (71%) | 41 (71%) |
Across all 418 studies, recruiting or not: 11% stop at 75 or younger and 1% at 65; 6% take children; 0% are for women only and 0% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Adenocarcinoma of Lung studies take
Of 53 phase 2 interventional studies under Adenocarcinoma of Lung, half reached primary completion within 53 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 53 mo33–71 · 53 studies | — | 53 mo33–73 · 45 studies |
| Observational | 65 mo29–65 · 36 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting1
Newly registered2
Studies
Recruiting first, then most recently updated. Showing 50 of 418. Browse all 418 → or search them.
- A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid TumorsRecruitingNCT07090499Phase 16 countries
- Testing the Safety of Dapagliflozin Prior to Surgery for the Treatment of Patients With Stage IA Lung AdenocarcinomaRecruitingNCT07235280Early Phase 11 country
- DBC-664 in Adult Patients With Solid TumorsRecruitingNCT07705035Phase 11 country
- PHOENIX: QL1706 Plus Chemotherapy and Bevacizumab in AGA-Resistant, PD-L1 ≥50% Non-Squamous NSCLCRecruitingNCT07416058Phase 21 country
- Firmonertinib Plus Chemotherapy for Unresectable EGFR PACC-Mutant Stage III Lung Cancer: A Phase II StudyNot yet recruitingNCT07878871Phase 21 country
- Phase 1 Study of NW-301V TCR-T Cells in Advanced Solid Tumors With KRAS G12V MutationNot yet recruitingNCT07875920Phase 11 country
- MOv19-BBz CAR T Cells in FRa+ CancersRecruitingNCT07116057Phase 11 country
- Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid TumorsRecruitingNCT05797168Phase 1/212 countries
- Primary Tumor Resection With EGFR TKI for Stage IV NSCLCRecruitingNCT05215548Phase 21 country
- RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II TrialRecruitingNCT04105270Phase 21 country
- SL-28 for Advanced Solid TumoursRecruitingNCT07341737Phase 1/21 country
- Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical ResectionRecruitingNCT055178111 country
- Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural EffusionNot yet recruitingNCT07482605Phase 2
- Inhaled Cromolyn Sodium in Patients With Locally Advanced Lung CancerNot yet recruitingNCT07675876Phase 11 country
- Ex Vivo Drug Response Profiling and Outcome Prediction in Lung AdenocarcinomaRecruitingNCT076362521 country
- Aumolertinib Combined With Phased Chemotherapy for EGFR L858R Lung AdenocarcinomaRecruitingNCT07624487Phase 21 country
- Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung CancerRecruitingNCT03199651Not applicable1 country
- Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CTNot yet recruitingNCT076476921 country
- Vortioxetine for Cognitive Function in ALK-positive NSCLC Treated With LorlatinibRecruitingNCT076336261 country
- CLINICAL STUDY TO IDENTIFY BIOMARKERS FOR TUMOR SPREAD THROUGH AIR SPACES STATUSNot yet recruitingNCT076302461 country
- A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South KoreaRecruitingNCT057035161 country
- Clinical Application of PET Imaging Targeting MSLN in Malignant TumorsRecruitingNCT068436291 country
- A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung AdenocarcinomaRecruitingNCT05456256Phase 23 countries
- Shared Decision Making in Patients With Lung CancerRecruitingNCT051914851 country
- Osimertinib to Suppress the Progression of Remaining GGN for EGFR Mutation-positive Stage IB-IIIA Lung AdenocarcinomaRecruitingNCT05528458Phase 21 country
- Segmentectomy Versus Lobectomy for Lung Adenocarcinoma ≤ 2cmRecruitingNCT04937283Not applicable1 country
- Pathogenic Variants in Genes Associated With Lung AdenocarcinomaRecruitingNCT061818121 country
- Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung CancerRecruitingNCT06495125Phase 21 country
- Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain MetastasesRecruitingNCT07481786Phase 31 country
- Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung CancerRecruitingNCT056655041 country
- Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung AdenocarcinomaRecruitingNCT07479095Not applicable1 country
- Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid TumorsRecruitingNCT04119024Phase 11 country
- Pleural Effusion Biomarkers in Lung Adenocarcinoma PatientsRecruitingNCT070127591 country
- Engagement of Veterans With Lung CancerRecruitingNCT07219251Not applicable1 country
- Partial Tumor Irradiation and Immunotherapy for Unresectable Lung CancerRecruitingNCT07423169Not applicable1 country
- Peripheral Blood ETASTs for Predicting Efficacy of Chemoimmunotherapy in NSCLCNot yet recruitingNCT07392073
- Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in 1st-line Treatment for Patients With Metastatic Lung AdenocarcinomaRecruitingNCT04339218Phase 31 country
- Evaluation of Different Sizes of Left-Sided Double-Lumen Tubes for Thoracic Surgery in a Tertiary Level Teaching HospitalNot yet recruitingNCT07373171Not applicable1 country
- Prediction of Targeted Therapy Efficacy in EGFR-mutant Lung Cancer Patients Using AI-based Multimodal DataNot yet recruitingNCT072879041 country
- ADH1B and ALDH Gene Variants and Lung Cancer RiskNot yet recruitingNCT07273279
- FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung AdenocarcinomaRecruitingNCT07058428Phase 31 country
- Segmentectomy vs Lobectomy for 2 - 3cm IASLC Grade 1-2 Lung Adenocarcinoma: A Multi-center RCTNot yet recruitingNCT07169903Phase 31 country
- Lorlatinib Compared with Concurrent/ Sequential Chemoradiotherapy in Stage III ALK Positive Lung AdenocarcinomaNot yet recruitingNCT06858410Phase 3
- Orlistat Overcoming Third-generation EGFR-TKI ResistanceNot yet recruitingNCT06818955Phase 2
- Lymph Node Pathologic Grading StrategyRecruitingNCT067458301 country
- Plasma Exosomes Reveal the Efficacy of Targeted Therapy in Patients With EGFR Mutation in Lung AdenocarcinomaEnrolling by invitationNCT067304771 country
- WSI Based DL for Diagnosing the IASLC Grading System of Lung AdenocarcinomaRecruitingNCT059257641 country
- Retrospective Analysis of Clinical and CT Features to Predict Spread Through Air Space in Stage IA Lung AdenocarcinomaNot yet recruitingNCT066457431 country
- Segmentectomy for Solid-dominant Lung CancerRecruitingNCT06634966Phase 31 country
- TP53 R248Q TCR-T Cell Therapy for Advanced Solid TumorNot yet recruitingNCT06619886Early Phase 11 country