ClinicalTrials.gg
Not yet recruitingNCT07934849AdaptGaitUpdated Nov 13, 2026

Gait Stability After Stroke

An interventional study of Level treadmill walking and Uphill treadmill walking in Stroke, sponsored by University Rehabilitation Institute, Republic of Slovenia. Not yet recruiting at 1 site in Slovenia. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-11-13.

Sponsored by University Rehabilitation Institute, Republic of Slovenia · Not applicable, Interventional, and Basic science

Updated Nov 13, 2026Newly registeredGo to Updates ↓

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Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Non-randomized
Ages
18 Years to 70 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-13

Among 20 studies in Stroke with a site in Slovenia — 4 open to participants now, 6 under way, 1 of them phase 3. Stroke · Slovenia.

Planned enrollment
7th of 15
50 · median 50
Started
2026
with 2 others
No phase
10 of 20
3 open now
Registered
20th of 20
by date
Lead sponsor
9 of 20
University Rehabilitation Institute, Republic of Slovenia

Among the 20 studies in Stroke with a site in Slovenia, this one is the 7th largest by planned enrollment of the 15 interventional ones that give a count, is one of 3 that started in 2026, is one of 10 with no phase, and was the 20th registered.

Stroke

8,268 studies on the registry are indexed under Stroke; 2,055 are open to participants now.

Browse Stroke studies →

Open to participants now

4 of the 20 studies in Stroke with a site in Slovenia are open now. Recruiting first, the newest first:

All 4 open studies →

A study can be open while its sites in Slovenia have not opened yet or have stopped. Only those recruiting at a site in Slovenia →

Who these studies take

Of the 1,415 Stroke studies recruiting now, 695 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 195 take healthy volunteers.

This study: 18 Years to 70 Years · all sexes · no healthy volunteers.

The full table on the hub →

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 20 studies in Stroke with a site in Slovenia, or all of them as a file.
02

Study summary

The study will investigate gait stability in individuals post-stroke compared with age- and sex-matched healthy adults. Participants will undergo laboratory-based walking assessments under different environmental conditions, including level walking, uphill and downhill walking, and unexpected slip perturbations, with and without added cognitive, postural, and load-carrying tasks. The primary outcome measures will be the Margin of Stability (MOS), step width, and step width variability.

Read the detailed description

: The study will recruit 20-30 adults post-stroke and an equal number of healthy controls. Participants post-stroke will be recruited after discharge from their regular rehabilitation. Participants will complete a single assessment session involving walking on a instrumented dual-belt treadmill mounted on a Stewart platform while secured with a safety harness. Walking conditions will include level, inclined, declined, and slip-perturbed walking, as well as walking combined with serial subtraction, head turning, or backpack carrying. Three-dimensional motion capture, force measurements, and surface electromyography will be used to quantify gait biomechanics and neuromuscular responses. The effects of environmental conditions and added tasks on gait stability, balance control, and fall risk will be compared between groups to identify biomechanical and neuromuscular markers associated with increased fall susceptibility after stroke.

03

Conditions studied

  • Stroke

Browse trials for

Keywords

  • gait stability
  • gait adaptability
  • stroke
  • falls
04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria - stroke group:

  • Discharge from regular rehabilitation
  • First unilateral ischemic or hemorrhagic stroke affecting one of the cerebral hemispheres
  • More than 3 months post-stroke
  • score ≥24 or cognitive ability to participate in the study
  • Ability to walk independently in the community without a walking aid
  • Moderate to mild balance impairment (Mini-BESTest score 16-25)
  • Sufficient cognitive and physical ability to participate
  • Ability to walk on a treadmill in intervals for up to 30 altogether

Inclusion Criteria - healthy control group:

  • Age- and sex-matched to participants with stroke
  • Mini-BESTest score ≥ 16
  • Sufficient cognitive and physical ability to participate
  • Ability to walk on a treadmill in intervals for up to 30 altogether

Exclusion Criteria (both groups):

  • Musculoskeletal impairments affecting gait or balance
  • Severe cardiovascular disease or heart failure ( Class III-IV)
  • Other neurological disorders
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

MMSE and MoCA

Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.

NYHA class (heart failure)

The New York Heart Association’s four classes of how much heart failure limits physical activity.

I
No limits: ordinary activity causes no undue tiredness or breathlessness.
II
Slight limits: comfortable at rest, ordinary activity causes symptoms.
III
Marked limits: comfortable at rest, less than ordinary activity causes symptoms.
IV
Symptoms even at rest; any activity makes them worse.

Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
50 participants (estimated)

Study arms

  • Active comparator
    Post-stroke patients

    Adults with unilateral stroke (\>3 months post-stroke) will undergo assessment of gait stability and balance responses during treadmill walking under different environmental conditions (level, uphill, downhill, and slip-perturbed walking) and added tasks (serial subtraction, head turning, and backpack carrying).

    Other: Level treadmill walking · Other: Uphill treadmill walking · Other: Downhill treadmill walking · Other: Slip-perturbed treadmill walking · Other: Added task: serial subtraction · Other: Added task: head turning · Other: Added task: backpack carrying

  • Active comparator
    Control group: healthy control participants

    Age- and sex-matched healthy adults will undergo the same assessment protocol as the post-stroke patients, i.e., assessment of gait stability and balance responses during treadmill walking under different environmental conditions (level, uphill, downhill, and slip-perturbed walking) and added tasks (serial subtraction, head turning, and backpack carrying).

    Other: Level treadmill walking · Other: Uphill treadmill walking · Other: Downhill treadmill walking · Other: Slip-perturbed treadmill walking · Other: Added task: serial subtraction · Other: Added task: head turning · Other: Added task: backpack carrying

Interventions

  • OtherLevel treadmill walking

    Level treadmill walking

  • OtherUphill treadmill walking

    Uphill treadmill walking

  • OtherDownhill treadmill walking

    Downhill treadmill walking

  • OtherSlip-perturbed treadmill walking

    Slip-perturbed treadmill walking

  • OtherAdded task: serial subtraction

    Added task: serial subtraction

  • OtherAdded task: head turning

    Added task: head turning

  • OtherAdded task: backpack carrying

    Added task: backpack carrying

06

What researchers measure

Primary outcomes

  1. Margin of Stability (MOS)

    Margin of stability in the anteroposterior and mediolateral directions calculated from kinematic and kinetic gait data during walking under different environmental conditions and added tasks, expressed in cm (more is better)

    Time frame: During the intervention (periprocedurally)

  2. Step Width

    Mean step width measured during walking under different environmental conditions and added tasks, expressed in cm (less is better)

    Time frame: During the intervention (periprocedurally)

  3. Step Width Variability

    Variability of step width calculated across consecutive gait cycles during walking under different environmental conditions and added tasks, , expressed as coeffcient of variation (less is better)

    Time frame: During the intervention (periprocedurally)

Secondary outcomes

  1. Spatiotemporal Gait Parameter 1: Cadence

    Gait cadence (in steps/min; less is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  2. Spatiotemporal Gait Parameter 2: Step Length

    Gait step length (in cm, more is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  3. Spatiotemporal Gait Parameter 3: Stance Time

    Gait stance time (in s, less is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  4. Spatiotemporal Gait Parameter 4: Swing Time

    Gait swing time (in cm, more is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  5. Kinetic Variable 1: Ground Reaction Force

    Ground reaction force in antero-posterior direction (in N; less is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  6. Kinetic Variable 2: Center-of-pressure Movement

    Center-of-pressure movement in antero-posterior and medio-lateral direction (in cm; less is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

  7. Kinetic Variable 3: Velocity

    Velocity in antero-posterior and medio-lateral direction (in cm/s; smaller is better) measured using the instrumented treadmill

    Time frame: During the intervention (periprocedurally)

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Nov 2026; primary completion for Nov 2028, 24 months later.

Of 3,111 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's planned 24 months is close to that.

Counting every sponsor, half of 3,255 studies reached it within 23 months; a quarter within 10 and three quarters within 46.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 30, 2026
First posted
Nov 13, 2026
StartEst.
Nov 2026
Primary completionEst.
Nov 2028
CompletionEst.
Nov 2029
Last update
Nov 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 13, 2026
Show all 1 update
  1. Nov 13, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07934849
Lead sponsor
University Rehabilitation Institute, Republic of Slovenia
Responsible party
Sponsor
First posted
Nov 13, 2026
Start date
Nov 2026 (estimated)
Primary completion
Nov 2028 (estimated)
Completion
Nov 2029 (estimated)
Last update
Nov 13, 2026

Study contacts

Katja Groleger Sršen, MD, PhD
Contact
katja.groleger@ir-rs.si
+386 1 4758283
Metka Močilar, MSc PT
principal investigator · University Rehabilitation Institute, Republic of Slovenia
Urška Puh, PT, PhD
study director · University Rehabilitation Institute, Republic of Slovenia

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

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