An interventional study of Manual Lymphatic Drainage and Classical Massage in Renal Dialysis, Renal Insufficiency, Chronic and Manual Lymphatic Drainage, sponsored by Mersin University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Mersin University · Not applicable, Interventional, and Supportive care
Among 112 studies in Renal Insufficiency, Chronic with a site in Turkey — 20 open to participants now, 30 under way, 14 of them phase 3. Renal Insufficiency, Chronic · Turkey.
Among the 112 studies in Renal Insufficiency, Chronic with a site in Turkey, this one is the 63rd largest by planned enrollment of the 81 interventional ones that give a count, is one of 5 that started in 2026, is one of 37 with no phase, reaches primary completion later than 12 of the 29 other live ones, and was the 111th registered.
3,090 studies on the registry are indexed under Renal Insufficiency, Chronic; 698 are open to participants now.
Browse Renal Insufficiency, Chronic studies →20 of the 112 studies in Renal Insufficiency, Chronic with a site in Turkey are open now. Recruiting first, the newest first:
AstraZeneca · Sites in Turkey, United States, Argentina and 24 more countries
Ages 18–99
Eli Lilly and Company · Sites in Turkey, Argentina, Australia and 35 more countries
Ages 50+
Izmir Democracy University · Sites in Turkey
Ages 8–18 · Healthy volunteers
AstraZeneca · Sites in Turkey, United States, Argentina and 39 more countries
Ages 18+
Novo Nordisk A/S · Sites in Turkey, United States, Argentina and 11 more countries
Ages 18+
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 435 Renal Insufficiency, Chronic studies recruiting now, 245 (56%) set no upper age limit and 111 (26%) stop at 75 or younger; 45 take children under 18; 80 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
112 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 5 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is below the median of 73 across 2,157 interventional studies indexed under Renal Insufficiency, Chronic.
Median enrollment 121 across the 81 interventional studies, 133 across the 31 observational. Of the 76 that completed or were terminated, 21 (28%) have results posted.
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43 of 112 have an industry lead sponsor. The 10 most frequent:
Mersin University is the lead sponsor of 181 studies on the registry; 48 are open to participants now.
Mersin University has 1 study filed under Renal Insufficiency, Chronic — fewer than ten, so there is no comparison to draw.
8 of the studies in Renal Insufficiency, Chronic with a site in Turkey that are under way reach primary completion within a year, 4 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05196035Phase 3BayerA Study to Learn More About How Well the Study Treatment Finerenone Works, How Safe it is, How it Moves Into, Through, and Out of the Body, and the Effects it Has on the Body When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker in Children With Chronic Kidney Disease and Proteinuria | 2027-04-10 |
| NCT07107945Phase 3Boehringer IngelheimA Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids) | 2027-04-16 |
| NCT05852938Phase 3Novartis PharmaceuticalsA Study of Zigakibart in Adults With IgA Nephropathy | 2027-08-10 |
| NCT05970172Phase 3Astellas Pharma Global Development, Inc.A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease | 2027-10-30 |
| NCT07932483Mersin UniversityManual Lymphatic Drainage Versus Classical Massage on Heart Responses and Mood in Hemodialysis | 2026-11-24 |
Add all 8 to your calendar (.ics) → With an account.
Among the 112 studies in Renal Insufficiency, Chronic with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this randomized controlled crossover trial is to learn whether manual lymphatic drainage (MLD) and classical massage have different short-term effects on the heart, the nervous system, and mood in adults aged 18 to 65 receiving hemodialysis. A total of 60 patients from two hemodialysis centers in Tarsus, Mersin, Türkiye, are planned to take part.
The main questions it aims to answer are:
Researchers will compare MLD with classical massage (active comparator). Each participant will receive both massages in a randomly assigned order (MLD first or classical massage first), so each participant serves as their own control. In addition, a no-massage control measurement will be taken in the week before the massages to show the changes caused by the hemodialysis session alone.
Participants will:
Cardiovascular disease is the leading cause of death in patients receiving hemodialysis (HD), accounting for about half of all deaths in this group. Blood pressure variability during dialysis is closely linked to cardiovascular events, and autonomic imbalance contributes to complications such as intradialytic hypotension and hypertension, each affecting about 15% of patients. Heart rate variability (HRV) is a non-invasive indicator of cardiac autonomic regulation and is reduced in chronic kidney disease. In addition, anxiety and depressive symptoms are common in HD patients and are associated with lower quality of life. Therefore, cardiovascular, autonomic, and emotional responses should be considered together during HD.
Massage is a low-cost, easy-to-apply, non-invasive nursing intervention with a low risk of serious side effects. Mechanical stimulation of the skin, muscle, and fascia may influence autonomic nervous system activity. Manual lymphatic drainage (MLD) is a technique that uses light, slow, rhythmic pressure to support lymphatic flow and has been associated with parasympathetic activation and relaxation. However, evidence on the cardiovascular and autonomic effects of MLD is limited, and its acute effects when applied during HD have not been studied.
Aim
The aim of this study is to evaluate and compare the acute cardiovascular, autonomic, and mood effects of 20-minute MLD and 20-minute classical massage applied during hemodialysis. The study is expected to help identify manual techniques that support cardiovascular and autonomic balance and to contribute to the development of evidence-based, non-pharmacological nursing interventions for HD care.
Originality
Previous massage studies in HD patients have mainly focused on symptoms and quality of life, such as fatigue, restless legs syndrome, muscle cramps, and sleep quality. Studies on the autonomic effects of MLD have mostly been conducted in healthy or stressed individuals. To the investigators' knowledge, no study has directly compared MLD and classical massage in terms of acute cardiovascular and autonomic responses in HD patients. This study is original in that:
Hypotheses
In hemodialysis patients, the effects of 20-minute MLD and 20-minute classical massage:
Methods
Design: Two-period, two-sequence (AB/BA), randomized controlled crossover study.
Participants: Patients aged 18 to 65 years who have received HD for at least three months, three times a week, about four hours per session. Main exclusion criteria are conditions preventing massage (e.g., foot ulcer, amputation, orthopedic problems), cancer, chronic respiratory failure, heart failure, rheumatoid arthritis, lupus, diagnosed psychiatric illness, use of sleeping pills or sedatives, atrial fibrillation, and pacemaker use.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will undergo a no-intervention control measurement (Z0), then receive 20 minutes of manual lymphatic drainage on both lower extremities during hemodialysis in Period 1, and after a one-week washout period, 20 minutes of classical massage in Period 2.
Other: Manual Lymphatic Drainage · Other: Classical Massage
Participants will undergo a no-intervention control measurement (Z0), then receive 20 minutes of classical massage on both lower extremities during hemodialysis in Period 1, and after a one-week washout period, 20 minutes of manual lymphatic drainage in Period 2.
Other: Manual Lymphatic Drainage · Other: Classical Massage
20-minute MLD applied to both lower extremities (thigh, lower leg, and foot) one hour after the start of the hemodialysis session, using light, slow, rhythmic, superficial stroking, pumping, circular, and rotary maneuvers directed toward the inguinal, popliteal, and medial malleolar lymphatic regions.
20-minute classical massage applied to both lower extremities (thigh, lower leg, and foot) one hour after the start of the hemodialysis session, using effleurage, petrissage, and friction, beginning and ending with effleurage.
Standard Deviation of Normal-to-Normal Intervals (SDNN)
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Root Mean Square of Successive Differences (RMSSD)
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Low Frequency (LF) Power
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
High Frequency (HF) Power
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Low Frequency to High Frequency Ratio (LF/HF)
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Systolic Blood Pressure
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Diastolic Blood Pressure
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Heart Rate
Time frame: Before the intervention, immediately after the 20-minute intervention, and 30 minutes after the post-intervention measurement, in each period
Fatigue Subscale Score of the Profile of Mood States - Short Form
Time frame: Before and immediately after the 20-minute intervention, in each intervention period
Vigor Subscale Score of the Profile of Mood States - Short Form
Time frame: Before and immediately after the 20-minute intervention, in each intervention period
Tension Subscale Score of the Profile of Mood States - Short Form
Time frame: Before and immediately after the 20-minute intervention, in each intervention period
Confusion Subscale Score of the Profile of Mood States - Short Form
Time frame: Before and immediately after the 20-minute intervention, in each intervention period
Plan to share: Yes
Supporting information: Study protocol
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for Nov 2026, 0 months later.
Of 576 non-industry interventional studies with no phase under Renal Insufficiency, Chronic, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 45. This study's planned 0 months is below that.
Counting every sponsor, half of 616 studies reached it within 23 months; a quarter within 10 and three quarters within 45.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Renal Insufficiency, Chronic →