An interventional study of Cyclic Sighing Breathing Exercise in Transurethral Resection of Bladder Tumor, Transurethral Resection of the Prostate (TURP) and Transurethral Resection of the Bladder, sponsored by Mersin University. Recruiting at 2 sites in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-06.
Sponsored by Mersin University · Not applicable, Interventional, and Other
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Among 11 studies in Sleep Initiation and Maintenance Disorders by Mersin University — 4 open to participants now, 4 under way, none of them phase 3. Sleep Initiation and Maintenance Disorders · Mersin University.
Among the 11 studies in Sleep Initiation and Maintenance Disorders by Mersin University, this one is the 2nd largest by planned enrollment, is one of 2 that started in 2026, is one of 11 with no phase, and was the 10th registered.
2,728 studies on the registry are indexed under Sleep Initiation and Maintenance Disorders; 730 are open to participants now.
Browse Sleep Initiation and Maintenance Disorders studies →4 of the 11 studies in Sleep Initiation and Maintenance Disorders by Mersin University are open now, in 1 country. Recruiting first, the newest first:
Mersin University · Sites in Turkey
Ages 21–60
Mersin University · Sites in Turkey
Ages 65–95 · Healthy volunteers
Mersin University
Ages 18–65 · Healthy volunteers
By country, each count listing its studies:
Of the 389 Sleep Initiation and Maintenance Disorders studies recruiting now, 152 (39%) set no upper age limit and 207 (53%) stop at 75 or younger; 59 take children under 18; 108 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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11 studies; the count open now beside each. This study's row is marked.
First in 2021; this study’s year is marked. 2 started in 2026.
This study's planned enrollment of 76 is above the median of 68 across 2,355 interventional studies indexed under Sleep Initiation and Maintenance Disorders.
Median enrollment 62 across the 11 interventional studies. Of the 7 that completed or were terminated, 0 (0%) have results posted.
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Mersin University is the lead sponsor of 181 studies on the registry; 47 are open to participants now.
2 of the studies in Sleep Initiation and Maintenance Disorders by Mersin University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07930455Mersin UniversityCold Therapy Following Laparoscopic Cholecystectomy | 2026-11-20 |
| NCT07843602Mersin UniversityEffect of Cyclic Sighing Breathing Exercise on CRBD, Pain, and Sleep Quality in Patients Undergoing TUR | 2027-02-28 |
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Among the 11 studies in Sleep Initiation and Maintenance Disorders by Mersin University, from their registry updates:
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Transurethral resection (TUR) is a common minimally invasive surgical procedure for lower urinary tract diseases. However, postoperative urinary catheterization often causes catheter-related bladder discomfort (CRBD) and pain due to bladder spasms, which negatively impact recovery and sleep quality. Pharmacological agents used to alleviate CRBD and pain may cause adverse side effects. This study aims to evaluate the effects of cyclic sighing breathing exercises on CRBD severity, pain intensity, and sleep quality in patients undergoing TUR.
This prospective, two-arm, parallel-group, randomized controlled clinical trial will be conducted in the Urology Ward of Hatay İskenderun State Hospital. A total of 76 patients scheduled for TUR (TUR-P or TUR-B/TUR-M) will be allocated into either the intervention group (n=38) or the control group (n=38) using block randomization with sealed opaque envelopes. The intervention group will receive pre-operative training on cyclic sighing breathing exercise. Postoperatively, participants in this group will perform cyclic sighing (two deep nasal inhalations followed by prolonged oral exhalation) for 5 minutes at the 1st, 2nd, 6th, 12th, and 24th postoperative hours under researcher supervision (completed before 22:00 to avoid nocturnal sleep disruption). The control group will receive routine standard postoperative nursing care. CRBD severity and pain intensity will be assessed at the 1st, 2nd, 6th, 12th, and 24th postoperative hours. Sleep quality will be evaluated on the morning of the first postoperative day (after awakening).
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients in this arm will receive preoperative training on the cyclic sighing breathing exercise technique from the researcher upon clinical admission. Following transurethral resection (TUR) surgery, participants will perform cyclic sighing breathing exercises under researcher supervision at the 1st, 2nd, 6th, 12th, and 24th postoperative hours. Each exercise session will last for 5 minutes and consists of taking a deep breath in through the nose, followed immediately by a second short breath to fully inflate the lungs, and then exhaling slowly and fully through the mouth. In addition to the breathing intervention, patients will receive standard postoperative clinical nursing care.
Other: Cyclic Sighing Breathing Exercise
Patients in this arm will receive routine standard postoperative nursing care and physician-prescribed clinical treatments (such as standard continuous bladder irrigation and routine analgesic or antispasmodic medications as needed) without any structured breathing exercise education or intervention.
The cyclic sighing intervention consists of structured breathing sessions taught preoperatively and supervised postoperatively. The patient assumes a comfortable supine or semi-Fowler position in bed. The exercise involves taking a slow, deep inhalation through the nose, immediately followed by a second short nasal inhalation to achieve maximum lung expansion, and then slowly and fully exhaling through the mouth, ensuring that exhalation lasts longer than inhalation. Patients perform this cycle continuously for 5 minutes at the 1st, 2nd, 6th, 12th, and 24th postoperative hours under researcher supervision. To protect nocturnal sleep patterns, sessions scheduled after 22:00 will be completed by 22:00.
Catheter-Related Bladder Discomfort (CRBD) Severity Score
Catheter-related bladder discomfort severity is assessed using the 4-point rating scale developed by Agarwal et al. The scale classifies discomfort as: 0 = none; 1 = mild (reported by the patient only upon direct questioning); 2 = moderate (reported spontaneously by the patient without being asked, but not accompanied by behavioral responses); and 3 = severe (reported spontaneously and accompanied by behavioral manifestations such as vocal complaints, restless limb movements, or attempting to pull out the urinary catheter). Higher scores indicate greater severity of bladder discomfort.
Time frame: Measured at the 1st, 2nd, 6th, 12th, and 24th postoperative hours
Postoperative Pain Intensity Score
Postoperative pain is assessed using the Numeric Rating Scale (NRS). Patients rate their perceived pain intensity on an 11-point scale from 0 to 10, where 0 represents "no pain" and 10 represents the "worst possible pain". Higher scores reflect higher pain intensity. In addition, total analgesic consumption and medication types will be recorded during the first 24 postoperative hours.
Time frame: Measured at the 1st, 2nd, 6th, 12th, and 24th postoperative hours.
Postoperative Sleep Quality Score
Sleep quality is assessed using the Richard-Campbell Sleep Questionnaire (RCSQ). The instrument evaluates 5 domains (sleep depth, sleep latency, awakenings, time spent awake, and overall sleep quality) using a 0-100 mm Visual Analog Scale (VAS). Total scores range from 0 to 100, with higher scores indicating superior sleep quality (scores \>50 denote good sleep quality).
Time frame: On the morning of postoperative day 1 (upon awakening)
Plan to share: No
Start is estimated for Nov 2026; primary completion for Feb 2027, 3 months later.
Of 1,211 non-industry interventional studies with no phase under Sleep Initiation and Maintenance Disorders, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 35. This study's planned 3 months is below that.
Counting every sponsor, half of 1,289 studies reached it within 15 months; a quarter within 6 and three quarters within 34.
Start moved once since we started tracking on Sep 25, 2026: Oct 2026 → Nov 2026, on Nov 6, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Sleep Initiation and Maintenance Disorders →