Surgical Window Study of CM93 in Subjects With Recurrent Glioblastoma (rGBM)

1. Have histologically confirmed recurrent or progressive World Health Organization grade 4 isocitrate dehydrogenase (IDH) wild type glioblastoma (WHO grade 4).
2. Archival tumor from initial or other prior surgery is documented to have epidermal growth factor receptor (EGFR) mutation or EGFR amplification, as detected by an FDA-approved test or CLIA-approved laboratory- developed test. For enrollment in the surgical window-of-opportunity study (Part 2), patients should have recurrent glioblastoma characterized by EGFR mutation or amplification who are candidates for surgical tumor debulking.
3. Previous first line therapy with at least radiotherapy utilizing standard dosing of central nervous system (CNS) radiation with or without chemotherapy.
4. Patients must have shown unequivocal evidence of tumor progression by MRI and have confirmed measurable disease per Response Assessment in Neuro-Oncology (RANO) criteria.

5. Patients must have confirmation of availability of sufficient tissue from prior surgery revealing glioblastoma for submission following registration for repeat EGFR mutation testing and additional sequencing. The following amount of tissue is required:

   • 1 formalin-fixed paraffin-embedded (FFPE) tumor tissue block (preferred) OR
   • 20 FFPE unstained slides (5 µm thickness)
6. Patients must have recovered to grade 0 or 1 as determined by the National Cancer Institute CTCAE version 6.0 or pre-treatment baseline from clinically significant toxic effects of prior therapy (including but not limited to exceptions for alopecia, laboratory values listed per inclusion criterion 10, and lymphopenia which is common after therapy with temozolomide).
7. An interval of at least 4 weeks (to registration) between prior surgical resection or one week from stereotactic biopsy.
8. Age ≥18 years. Because no dosing or adverse event data are currently available on the use of CM93 in participants \<18 years of age, children are excluded from this study but will be eligible for future pediatric trials.
9. Karnofsky performance status ≥ 60 (Appendix A).

10. Participants must have adequate organ and marrow function as defined below:

    • absolute neutrophil count ≥1,500/mcL
    • hemoglobin ≥ 8g/dL
    • platelets ≥100,000/mcL
    • total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (subjects with Gilbert syndrome are allowed if direct bilirubin within normal limits)
    • AST(SGOT)/ALT(SGPT) ≤3 × institutional ULN
    • creatinine clearance ≥60mL/min from a 24 hour urine collection or calculated based on the Cockcroft-Gault formula
    • negative serum β-hCG test in women of childbearing potential (defined as women ≤50 years of age, or >50 years of age with a history of amenorrhea ≤12 months prior to study entry).
11. Left ventricular ejection fraction (LVEF) at least 50% as confirmed by echocardiogram (TTE) or multigated acquisition scan (MUGA).
12. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, participants should be class II or better.
13. The effects of CM93 on the developing human fetus are unknown. For that reason, women of childbearing age must agree to use dual contraceptive methods which, in the opinion of the principal investigator, are effective and adequate for that subject's circumstances while on study drug and for 4 months afterward.
14. Men who partner with a woman of childbearing potential must agree to use effective, dual contraceptive methods (i.e., a condom, with female partner using oral, injectable or barrier method) while on study drug and for 4 months afterward.

15. Ability to understand and the willingness to sign a written informed consent document.

    Additional criteria for window-of-opportunity surgical cohort

16. Patients must be undergoing surgery for recurrent or progressive disease that is clinically indicated as determined by their care providers.
17. Ability of a neurosurgeon to gross or subtotally resect both enhancing and non-enhancing components of the tumor and that sufficient tissue can be obtained for from each component for correlative studies. The local treating team must confirm that there is sufficient resectable tumor tissue from both enhancing and non-enhancing areas of tumor for evaluation of study endpoints.

Exclusion Criteria:

1. Prior evidence of IDH mutation by IHC or DNA sequencing (i.e., IDH wild type only)
2. Participants who have had prior treatment with any EGFR inhibitor, or Vascular endothelial growth factor (VEGF) or Vascular endothelial growth factor receptor (VEGFR) inhibitor.
3. Participants who have had temozolomide less than 23 days from study initiation, treatment with CCNU (Lomustine) or BCNU (Carmustine) less than 42 days from study initiation, or treatment with any cancer- directed systemic therapy less than 4 weeks or 5 half-lives from study initiation, whichever is shorter.
4. Participants who have had any cancer-directed immunomodulatory or molecularly-targeted agent or monoclonal antibody within 14 days prior to initiation of study drug.
5. Participants who have used any investigational agents within 28 days or 5 half-lives from study initiation, whichever is shorter.
6. For phase 1 dose escalation and dose expansion: increasing corticosteroid requirement or a dose >6 mg per day of dexamethasone or equivalent dose of other corticosteroids within 7 days prior to study initiation. This does not apply to patients in the window-of-opportunity surgical trial.
7. Participants who received radiation therapy within 12 weeks prior to registration, unless there is surgical confirmation of recurrent disease or evidence of new enhancing recurrent disease outside of the prior radiotherapy treatment field.
8. Participants with major surgery within the last 28 days prior to registration.
9. History of allergic reactions attributed to compounds of similar chemical or biologic composition to CM93.
10. Participants receiving any medications or substances that are strong inhibitors or sensitive substrates of CYP3A4 (e.g., clarithromycin, azole antifungals, protease inhibitors, nefazadone, grapefruit juice, midazolam, triazolam) or those metabolized by CYP 3A4/3A5 are ineligible. Caution is advised for participants taking dexamethasone as well as strong inducers of its metabolism. Because the lists of these agents are constantly changing, it is important to regularly consult a frequently-updated medical reference. As part of the enrollment/informed consent procedures, the participant will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the participant is considering a new over-the-counter medicine or herbal product.
11. Participants receiving any medications or substances that are sensitive BCRP substrates (e.g., rosuvastatin, sulfazalazine) are ineligible unless the agent can be safely discontinued at least 4 days prior to study entry.
12. Participants receiving a proton pump inhibitor (PPI) within 4 days prior to the start of study therapy or a histamine H2 blocker within 2 days prior to the start of study therapy are ineligible.
13. Participants with known human immunodeficiency virus or acquired immunodeficiency syndrome-related illness.
14. Participants with any of the following within 12 months prior to initiation of study drug: uncontrolled congestive heart failure, history of known heart failure New York Heart Association Classification > II or higher, or unstable angina.
15. Patients with a history of myocardial infarction or coronary/peripheral artery bypass graft surgery.
16. Participants with any of the following within 6 months prior to initiation of study drug: cerebrovascular accident, transient ischemic attack.
17. Pulmonary embolism within 1 month prior to initiation of study drug.
18. History of clinically significant or unstable cardiac dysrhythmias or persistent prolongation of the QTc (Fridericia) interval to >470msec.
19. Any contraindication to contrast-enhanced MRI examination.
20. Evidence of present or prior Grade ≥ 2 intracranial hemorrhage.
21. Participants with any severe, acute, or chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration, may interfere with the informed consent process and/or with compliance with the requirements of the study, or may interfere with the interpretation of study results and, in the Investigator's opinion, would make the subject inappropriate for entry into this study.
22. Participants with uncontrolled intercurrent illness, including active or clinically unstable bacterial, viral or fungal infection requiring systemic therapy.
23. Pregnant women are excluded from this study; there are no reproductive toxicity data at the stage of development in animals. CM93 may have potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with CM93, breastfeeding should be discontinued if the mother is treated with CM93.
24. Previous malignancy, except for non-squamous cell cancer of the skin or carcinoma in situ of the uterine or cervix, unless the natural history or treatment of the tumor does not interfere with the safety or efficacy assessment of the investigational regimen.
25. Participants with difficulty swallowing/unable to swallow pills; malabsorption syndrome; refractory nausea and vomiting, chronic gastrointestinal (GI) disease or previous significant bowel resection with clinically significant sequelae that would preclude adequate absorption of study drug.

Additional criteria for window-of-opportunity surgical cohort

24. Participants with >2 prior relapses of glioblastoma.