An interventional study of Rhodiola Rosea Capsules and Caffeine in Muscle Fatigue (C23.888.592.612.612), sponsored by MARINA MEDINA CORRALES. Not yet recruiting at 1 site in Mexico. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-09.
Sponsored by MARINA MEDINA CORRALES · Not applicable, Interventional, and Basic science
The goal of this clinical trial is to evaluate if combined acute supplementation with Rhodiola rosea and caffeine is superior to single-ingredient intake or placebo in attenuating neuromuscular fatigue in advanced resistance-trained subjects.
The main questions it aims to answer are:
Does combined supplementation attenuate mean propulsive velocity loss during heavy resistance exercise? Does combined supplementation reduce ratings of perceived exertion and increase repetitions performed to failure?
Researchers will compare four experimental conditions (placebo, caffeine alone, Rhodiola rosea alone, and combined supplementation) in a randomized crossover design to see if co-ingestion provides superior anti-fatigue benefits.
Participants will:
Complete a familiarization session to establish individual strength baselines. Attend 4 testing visits separated by a 72-hour washout period. Ingest the assigned treatment before testing. Perform a back squat fatigue protocol (3 sets at 70% 1RM) and complete perceptual evaluations.The goal of this clinical trial is to evaluate if combined acute supplementation with Rhodiola rosea and caffeine is superior to single-ingredient intake or placebo in attenuating neuromuscular fatigue in advanced resistance-trained subjects.
The main questions it aims to answer are:
Does combined supplementation attenuate mean propulsive velocity loss during heavy resistance exercise? Does combined supplementation reduce ratings of perceived exertion and increase repetitions performed to failure?
Researchers will compare four experimental conditions (placebo, caffeine alone, Rhodiola rosea alone, and combined supplementation) in a randomized crossover design to see if co-ingestion provides superior anti-fatigue benefits.
Participants will:
Complete a familiarization session to establish individual strength baselines. Attend 4 testing visits separated by a 72-hour washout period. Ingest the assigned treatment before testing. Perform a back squat fatigue protocol (3 sets at 70% 1RM) and complete perceptual evaluations.
This study is a randomized, double-blind, placebo-controlled, four-arm crossover trial designed to investigate the acute neuromuscular and ergogenic effects of single and combined supplementation with Rhodiola rosea (1,000 mg) and caffeine (3 mg/kg) in advanced resistance-trained subjects.
Neuromuscular fatigue during heavy resistance training impairs movement velocity, power output, and overall volume performance. While caffeine is a central nervous system stimulant that enhances motor unit recruitment and reduces perceived exertion, Rhodiola rosea is an adaptogen proposed to modulate central monoamines and attenuate fatigue during high-intensity effort. This protocol evaluates whether co-ingestion provides a synergistic advantage over isolated administration or placebo in maintaining movement execution quality and accelerating acute recovery.
Study Procedures:
Familiarization Session: Prior to the experimental trials, participants complete a familiarization session to establish baseline measurements and estimate 1-repetition maximum (1RM) in the barbell back squat using a two-point load-velocity method (using loads corresponding to \~1.0 m/s and \~0.5 m/s) with a linear position transducer.
Experimental Trials (4 Visits): Participants complete four experimental testing visits in a randomized, counterbalanced order, separated by a 72-hour washout period.
During each of the 4 experimental visits, participants complete the following sequence:
Supplement Ingestion: Double-blind administration of the assigned treatment:
Rhodiola placebo consists of opaque cornstarch capsules. Caffeine placebo consists of a 60 mL liquid solution containing sweetener, 3 g of sugar, and 1 g of citric acid.
Active conditions consist of 1,000 mg of Rhodiola rosea and/or 3 mg/kg of caffeine.
Pre-Exercise Evaluation: Completion of baseline perceptual questionnaires. Velocity Determination: Identification of the exact load corresponding to a Mean Propulsive Velocity (MPV) of 1.0 ± 0.03 m/s in the back squat.
Acute Fatigue Protocol: Execution of 3 sets at 70% estimated 1RM in the back squat performed to muscular failure, recording total repetitions and velocity loss across sets.
Post-Fatigue Velocity Recovery: Re-assessment of MPV using the pre-determined 1.0 m/s load at exactly 1 minute and 2 minutes post-fatigue protocol to evaluate acute neuromuscular fatigue and velocity recovery.
Perceptual Evaluation: Rating of Perceived Exertion (RPE) recorded post-exercise.
2,229 studies on the registry are indexed under Fatigue; 426 are open to participants now.
This study's planned enrollment of 20 is below the median of 54 across 1,757 interventional studies indexed under Fatigue.
Browse Fatigue studies →This is the only study on the registry with MARINA MEDINA CORRALES as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Placebo condition consisting of opaque cornstarch capsules and a 60 mL placebo liquid solution.
Other: Rhodiola Placebo · Other: Caffeine Placebo
Single administration of caffeine alongside placebo capsules.
Dietary Supplement: Caffeine · Other: Rhodiola Placebo
Single administration of Rhodiola rosea alongside placebo liquid solution.
Dietary Supplement: Rhodiola Rosea Capsules · Other: Caffeine Placebo
Combined administration of Rhodiola rosea and caffeine.
Dietary Supplement: Rhodiola Rosea Capsules · Dietary Supplement: Caffeine
1,000 mg of Rhodiola rosea administered in opaque capsules.
3 mg/kg of caffeine administered in a 60 mL liquid solution.
Opaque cornstarch capsules matching the active Rhodiola capsules.
60 mL liquid solution containing sweetener, 3 g of sugar, and 1 g of citric acid.
Percentage Loss in Mean Propulsive Velocity (MPV)
Percentage loss in mean propulsive velocity (MPV) following the fatiguing protocol. MPV is assessed during the barbell back squat using an individualized load corresponding to an initial velocity of 1.0 ± 0.03 m/s, recorded via a linear position transducer. Percentage loss is calculated relative to pre-fatigue baseline as: \[(baseline MPV - post-fatigue MPV) / baseline MPV\] × 100. The fatiguing protocol consists of 3 sets to failure at 70% 1RM.
Time frame: Baseline (pre-fatigue), 1 minute, and 2 minutes post-fatiguing exercise protocol, up to 2 weeks.
Total Number of Repetitions to Failure
Cumulative number of successful repetitions completed across 3 sets at 70% 1RM performed to momentary muscular failure during the fatiguing protocol. Data are reported as the total number of repetitions completed per experimental condition.
Time frame: Immediately upon completion of the fatiguing exercise protocol, up to 2 weeks
Rating of Perceived Exertion (RPE)
Subjective perception of effort assessed using a standardized RPE scale immediately following the fatiguing protocol to quantify internal load.
Time frame: Immediately, 1 minute, and 2 minutes post-fatiguing exercise protocol, up to 2 weeks
Plan to share: Yes
Supporting information: Informed consent form, Analytic code
Time frame: Data will become available after publication of the main manuscript in a peer-reviewed journal and will remain accessible indefinitely.
Access criteria: Data and supporting materials will be publicly accessible via the Open Science Framework (OSF) repository to any researcher interested in secondary or meta-analysis.
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Nov 2026, 0 months later.
Of 936 non-industry interventional studies with no phase under Fatigue, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 27. This study's planned 0 months is below that.
Counting every sponsor, half of 989 studies reached it within 11 months; a quarter within 5 and three quarters within 27.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Caffeine