CompletedNCT07919561CHX; EOMWUpdated Nov 5, 2026

EFFECTIVENESS OF DILUTED CHLORHEXIDINE AND ESSENTIAL OIL BASED MOUTHWASHES ON PLAQUE IN ORTHODONTIC PATIENTS- A RANDOMIZED CONTROLLED TRIAL

An interventional study of diluted 0.2% Chlorhexidine mouthwash and Essential Oil-Based Mouthwash in Dental Plaque Accumulation, sponsored by Rehman Medical Institute - RMI. Completed at 1 site in Pakistan. Open to participants aged 14 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-05.

Sponsored by Rehman Medical Institute - RMI · Not applicable, Interventional, and Treatment

From the registry’s dates

Registered 1 year 3 months after the study started (first participant enrolled Jul 2025, registered Oct 2026).

Updated Nov 5, 2026Newly registeredGo to Updates ↓

Phase: Not applicable
Study type: Interventional
Enrollment: 30
Allocation: Randomized
Ages: 14 Years to 40 Years
Sex: All

Study summary

This randomized clinical trial compares the effectiveness of a chlorhexidine mouthwash with an essential-oil-based mouthwash in improving oral health outcomes. Participants will be assigned to one of the two mouthwash groups and will use the assigned mouthwash according to the study protocol. Oral health parameters will be assessed at baseline and after the follow-up period to determine and compare the effects of the two mouthwashes.

Read the detailed description

This study is a randomized clinical trial designed to compare the effectiveness of two mouthwash formulations: chlorhexidine mouthwash and an essential-oil-based mouthwash.

Eligible participants will be enrolled according to the predefined inclusion and exclusion criteria and randomly allocated into two groups. Group 1 (G1) will receive chlorhexidine mouthwash, while Group 2 (G2) will receive an essential-oil-based mouthwash.

Baseline oral health measurements will be recorded before the intervention. Participants will then use their assigned mouthwash according to the study protocol. Follow-up assessment will be performed after 3 months, and the relevant oral health outcomes will be recorded.

The outcomes measured at baseline and follow-up will be compared within and between the two groups to determine the effectiveness of the two mouthwash interventions. The study findings will help evaluate the comparative effects of chlorhexidine and essential-oil-based mouthwash on the selected oral health outcomes.

Conditions studied

Dental Plaque Accumulation

Browse trials for

Dental Plaque 352

In context

Dental Plaque

352 studies on the registry are indexed under Dental Plaque; 60 are open to participants now.

This study's enrollment of 30 is below the median of 56 across 316 interventional studies indexed under Dental Plaque.

Browse Dental Plaque studies →

Lead sponsor

Rehman Medical Institute - RMI is the lead sponsor of 24 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 14 Years to 40 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

a. Patient with mild to moderate gingivitis (OPI scores more than 2 on any three standard teeth) b. No prior use of phenytoin, cyclosporin, or any other medication known to cause gingival enlargement medication c. No systemic problems like Diabetes mellitus, blood disorder etc d. Age above 14 years with completely erupted permanent dentition e. Patient who are under comprehensive orthodontic treatment for at least 3 months f. Mild to moderate crowding (up to 6mm)

Exclusion criteria

Exclusion Criteria:

a. Pregnant women and lactating mother b. Enamel defects (enamel hypoplasia or fluorosis discoloration) c. Periodontal intervention done in the last six months (surgical or non-surgical)

Study design

Phase: Not applicable
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Triple (Participant, Investigator, Outcomes assessor)
Enrollment: 30 participants (actual)

Study arms

Experimental
G1 (diluted 0.2% chlorhexidine mouthwash)
G1 (diluted 0.2% chlorhexidine mouthwash)
Other: diluted 0.2% Chlorhexidine mouthwash
Experimental
G2 (essential oil based mouthwashes)
G2 (essential oil based mouthwashes)
Other: Essential Oil-Based Mouthwash

Interventions

Otherdiluted 0.2% Chlorhexidine mouthwash
Diluted 0.2% chlorhexidine mouthwash administered to participants assigned to G1 according to the study protocol.
OtherEssential Oil-Based Mouthwash
Essential oil-based mouthwash administered to participants assigned to G2 according to the study protocol.

What researchers measure

Primary outcomes

The Orthodontic Plaque Index (OPI)
Change in the Orthodontic Plaque Index (OPI) score from baseline to 3 months was used to assess the effectiveness of the intervention.
Time frame: Baseline to 3 months

Study locations

1 site

Rehman Medical Institute
Peshawar, KPK 25000, Pakistan

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

Timeline

1 registry update since Sep 25, 2026

ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Jul 2025 to primary completion in Jan 2026, 6 months.

Of 133 non-industry interventional studies with no phase under Dental Plaque, half reached primary completion within 7 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 16. This study's 6 months is below that.

Counting every sponsor, half of 178 studies reached it within 6 months; a quarter within 2 and three quarters within 14.

How these figures are worked out, and which studies are left out of them.

Registered: Oct 30, 2026
First posted: Nov 5, 2026
StartActual: Jul 10, 2025
Primary completionActual: Jan 10, 2026
CompletionActual: Jan 10, 2026
Last update: Nov 5, 2026

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

Registered

First appeared on the registry. No changes since

Nov 5, 2026

Show all 1 update

Nov 5, 2026
First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT07919561
Lead sponsor: Rehman Medical Institute - RMI
Responsible party: Sponsor
First posted: Nov 5, 2026
Start date: Jul 10, 2025
Primary completion: Jan 10, 2026
Completion: Jan 10, 2026
Last update: Nov 5, 2026

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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