An interventional study of AI-Supported Mobile Health Application and Home-Based Exercise Program in Osteopenia, sponsored by Istanbul University. Active, not recruiting at 1 site in Turkey (Türkiye). Open to female participants aged 42 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Istanbul University · Not applicable, Interventional, and Treatment
Among 22 studies in Bone Diseases, Metabolic with a site in Turkey — 2 open to participants now, 4 under way, none of them phase 3. Bone Diseases, Metabolic · Turkey.
Among the 22 studies in Bone Diseases, Metabolic with a site in Turkey, this one is the 4th largest by enrollment of the 11 interventional ones that give a count, is one of 5 that started in 2025, is one of 9 with no phase, and was the 22nd registered.
661 studies on the registry are indexed under Bone Diseases, Metabolic; 93 are open to participants now.
Browse Bone Diseases, Metabolic studies →2 of the 22 studies in Bone Diseases, Metabolic with a site in Turkey are open now. Recruiting first, the newest first:
Kanuni Sultan Suleyman Training and Research Hospital · Sites in Turkey
Ages 18+
Firat University · Sites in Turkey
Ages 18–65 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 63 Bone Diseases, Metabolic studies recruiting now, 27 (43%) set no upper age limit and 28 (44%) stop at 75 or younger; 12 take children under 18; 22 take healthy volunteers.
This study: 42 Years to 65 Years · female · no healthy volunteers.
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22 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 5 started in 2025.
This study's enrollment of 76 is above the median of 60 across 509 interventional studies indexed under Bone Diseases, Metabolic.
Median enrollment 27 across the 11 interventional studies, 100 across the 11 observational. Of the 15 that completed or were terminated, 1 (7%) have results posted.
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1 of 22 have an industry lead sponsor. The 10 most frequent:
Istanbul University is the lead sponsor of 512 studies on the registry; 78 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 1 (20%) have results posted.
Istanbul University has 1 study filed under Bone Diseases, Metabolic — fewer than ten, so there is no comparison to draw.
2 of the studies in Bone Diseases, Metabolic with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07918716Istanbul UniversityAI-Supported Mobile High-Impact and Strengthening Exercise Program in Postmenopausal Women With Low Bone Density | 2026-12 |
| NCT07677033Kanuni Sultan Suleyman Training and Research HospitalFunctional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study | 2027-05-01 |
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Among the 22 studies in Bone Diseases, Metabolic with a site in Turkey, from their registry updates:
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Low bone mineral density after menopause increases the risk of osteoporosis and fractures, and regular exercise can help preserve bone health. However, adherence to home exercise programs is often low. This randomized controlled trial aims to evaluate whether an artificial intelligence-supported mobile health application improves the effects of a home exercise program in postmenopausal women with osteopenia. Participants will be randomly assigned to two groups. Both groups will perform the same 6-month home-based bodyweight strengthening and high-impact exercise program three times per week, using a printed exercise booklet and an exercise adherence log; one group will perform the same exercise program using the mobile application. Bone mineral density, functional status, fall risk, quality of life, and active participation as reflected by exercise adherence will be compared between the groups at baseline and after 6 months.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will perform the same 6-month home-based bodyweight strengthening and high-impact exercise program using an artificial intelligence-assisted mobile health application (Agit) that guides and supports the exercise sessions. Participants will perform the program three times per week. Participants will also receive a printed exercise booklet and an exercise adherence log.
Behavioral: AI-Supported Mobile Health Application · Behavioral: Home-Based Exercise Program
Participants in this arm will perform the same 6-month home-based bodyweight strengthening and high-impact exercise program independently at home using a printed exercise booklet and an exercise adherence log. Participants will perform the program three times per week.
Behavioral: Home-Based Exercise Program
An artificial intelligence-assisted mobile health application that delivers and supports the home-based exercise program for 6 months, providing exercise instructions, guidance, and progression.
Also known as: Agit
A 6-month home-based bodyweight strengthening and high-impact exercise program, provided through a printed exercise booklet and an exercise adherence log. Participants will perform the program three times per week.
Change From Baseline in Lumbar Spine (L1-L4) Bone Mineral Density
Lumbar spine (L1-L4) bone mineral density will be measured by dual-energy X-ray absorptiometry (DXA). The outcome will be expressed as the mean change in bone mineral density from baseline to 6 months, in g/cm².
Time frame: Baseline and 6 months
Change From Baseline in Femoral Neck Bone Mineral Density
Femoral neck bone mineral density will be measured by dual-energy X-ray absorptiometry (DXA). The outcome will be expressed as the mean change in bone mineral density from baseline to 6 months, in g/cm².
Time frame: Baseline and 6 months
Change From Baseline in Total Hip Bone Mineral Density
Total hip bone mineral density will be measured by dual-energy X-ray absorptiometry (DXA). The outcome will be expressed as the mean change in bone mineral density from baseline to 6 months, in g/cm².
Time frame: Baseline and 6 months
Change From Baseline in Timed Up and Go (TUG) Test
Functional status will be assessed with the Timed Up and Go test, which measures the time in seconds required to rise from a chair, walk 3 meters, turn, walk back, and sit down. Shorter times indicate better functional status.
Time frame: Baseline and 6 months
Change From Baseline in Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) Score
Quality of life will be assessed with the QUALEFFO-41 questionnaire. Total scores range from 0 to 100, with higher scores indicating worse quality of life.
Time frame: Baseline and 6 months
Exercise Adherence Rating Scale (EARS) Score
Self-reported exercise adherence, as an indicator of active participation in the exercise program, will be assessed with the Exercise Adherence Rating Scale at 1 month and 6 months after the start of the intervention. The adherence score ranges from 0 to 24, with higher scores indicating better adherence.
Time frame: 1 month and 6 months
Change From Baseline in Fall Risk Index Measured by Computerized Posturography
Fall risk will be assessed with the Tetrax Interactive Balance System, a posturographic device that calculates a fall risk index ranging from 0 to 100 based on postural sway measurements in eight standing positions. Higher scores indicate greater fall risk.
Time frame: Baseline and 6 months
Plan to share: No — Individual participant data will not be shared publicly due to participant confidentiality. De-identified data may be made available from the principal investigator upon reasonable request.
No publications or documents are linked to this record.
Started Dec 2025 (actual). Primary completion is estimated for Dec 2026, 12 months after the start.
Of 161 non-industry interventional studies with no phase under Bone Diseases, Metabolic, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 38. This study's planned 12 months is below that.
Counting every sponsor, half of 177 studies reached it within 22 months; a quarter within 10 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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