An observational study in Periodontitis and Type 2 Diabetes Mellitus, sponsored by Dicle University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 35 Years and older. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Dicle University · Observational
This study evaluated the effects of non-surgical periodontal therapy on periodontal health and inflammatory markers in patients with periodontitis, with and without type 2 diabetes mellitus.
Participants were divided into three groups according to their diabetes status and glycemic control: patients without diabetes, patients with well-controlled type 2 diabetes, and patients with poorly controlled type 2 diabetes.
Periodontal clinical measurements and gingival crevicular fluid and blood samples were collected at baseline. Participants subsequently received non-surgical periodontal therapy. Clinical measurements and biological samples were collected again three months after treatment.
The study assessed changes in periodontal clinical parameters and inflammatory biomarkers, including interleukin-4 (IL-4) and interleukin-17 (IL-17), to investigate whether responses to periodontal treatment differed according to diabetes status and glycemic control.
1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.
This study's enrollment of 45 is below the median of 90 across 372 observational studies indexed under Periodontitis.
Browse Periodontitis studies →Dicle University is the lead sponsor of 28 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population consisted of 45 patients with chronic periodontitis who attended the Department of Periodontology, Faculty of Dentistry, Dicle University, Türkiye. Participants were classified into three groups according to their type 2 diabetes status and glycemic control: systemically healthy patients with periodontitis (n=16), patients with well-controlled type 2 diabetes and periodontitis (n=15), and patients with poorly controlled type 2 diabetes and periodontitis (n=14).
Eligible participants were older than 35 years, had at least 20 teeth, and had periodontal involvement affecting at least 30% of their teeth, with probing depth ≥5 mm and clinical attachment loss ≥2 mm. All participants received routine non-surgical periodontal treatment and were evaluated at baseline and three months after treatment.
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Exclusion Criteria
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Change in Gingival Crevicular Fluid and Serum IL-4 Levels
IL-4 levels measured in gingival crevicular fluid and serum before and 3 months after non-surgical periodontal therapy in three groups classified by type 2 diabetes status and glycemic control.
Time frame: Baseline and 3 months after periodontal therapy
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Aug 2017 to primary completion in May 2018, 9 months.
Of 85 non-industry observational studies under Periodontitis, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 30. This study's 9 months is below that.
Counting every sponsor, half of 86 studies reached it within 13 months; a quarter within 7 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Dicle University