An observational study in Knee Osteoarthritis, sponsored by Ankara Training and Research Hospital. Recruiting at 2 sites in Turkey (Türkiye). Open to participants aged 40 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by Ankara Training and Research Hospital · Observational
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.
Knee osteoarthritis is a common degenerative joint disease associated with chronic pain, functional limitation, and reduced quality of life. Various non-surgical treatment modalities have been used to manage symptoms; however, the effectiveness of these treatments may be limited due to the complex pain mechanisms involved in osteoarthritis.
Perineural injection therapy has gained increasing attention as a minimally invasive treatment option targeting neurogenic inflammation around peripheral sensory nerves. Perineural 5% dextrose injection is thought to reduce pain by modulating neurogenic inflammation, while local anesthetic injections are commonly used in clinical practice for symptomatic relief.
This study is designed as a prospective observational cohort study conducted in a routine clinical setting. Patients aged 40 to 65 years with symptomatic knee osteoarthritis who are treated with perineural injections as part of standard care will be included. The choice of injectate (perineural 5% dextrose or perineural local anesthetic) will be determined based on clinical considerations and patient preference; no randomization or protocol-driven assignment will be performed.
Pain severity will be evaluated using the Visual Analog Scale (VAS). Functional status will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additional clinical parameters, including knee range of motion measured by goniometry and quadriceps muscle strength assessed by manual muscle testing, will also be recorded. Assessments will be performed at baseline, and at 1, 3, and 6 months following treatment.
Clinical outcomes of the two treatment groups will be compared to evaluate changes in pain and functional status over time. The findings of this study are expected to contribute real-world evidence regarding the clinical effectiveness of perineural 5% dextrose and local anesthetic injections in the management of symptomatic knee osteoarthritis.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 86 is below the median of 100 across 486 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Ankara Training and Research Hospital is the lead sponsor of 48 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients aged 40 to 65 years with symptomatic knee osteoarthritis who are receiving perineural injection therapy as part of routine clinical care. Eligible participants include both male and female patients who meet the predefined inclusion and exclusion criteria and are able to provide written informed consent.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with symptomatic knee osteoarthritis receiving perineural 5% dextrose injections as part of routine clinical care.
Procedure: Perineural 5% Dextrose Injection
Patients with symptomatic knee osteoarthritis receiving perineural local anesthetic injections as part of routine clinical care.
Procedure: Perineural Local Anesthetic Injection
Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.
Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.
Change in Knee Pain Intensity (Visual Analog Scale [VAS])
Change in Knee Pain Intensity (Visual Analog Scale \[VAS\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in Functional Status (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC])
Change from baseline in WOMAC total score (and/or subscales: pain, stiffness, and physical function) assessing knee osteoarthritis-related symptoms. The WOMAC consists of 24 items with a total score ranging from 0 to 96; higher scores indicate worse symptoms and worse functional status.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in Knee Range of Motion
Change in knee joint range of motion measured using goniometry.
Time frame: Baseline, 1 month, 3 months, and 6 months
Change in Quadriceps Muscle Strength
Change in quadriceps muscle strength assessed by manual muscle testing.
Time frame: Baseline, 1 month, 3 months, and 6 months
Plan to share: No — Individual participant data (IPD) will not be shared. This is an observational, single-center study conducted in a hospital setting. The study includes sensitive clinical information, and individual-level data cannot be sufficiently de-identified for public sharing. Only aggregate results will be reported in scientific publications.
Started Feb 2026 (actual). Primary completion is estimated for Nov 2026, 8 months after the start.
Of 179 non-industry observational studies under Osteoarthritis, Knee, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 48. This study's planned 8 months is below that.
Counting every sponsor, half of 220 studies reached it within 24 months; a quarter within 14 and three quarters within 61.
How these figures are worked out, and which studies are left out of them.
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Ankara Training and Research Hospital