An interventional study of Ultrasound-Guided Pericapsular Nerve Group Block with Bupivacaine and Ultrasound-Guided Placebo Injection with Normal Saline in Morphine Consumption and Postoperative Pain, sponsored by Cumhuriyet University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Cumhuriyet University · Not applicable, Interventional, and Treatment
This study evaluated whether an ultrasound-guided pericapsular nerve group (PENG) block could reduce pain and morphine use during the first 24 hours after hip surgery. A PENG block involves injecting a local anesthetic near nerves that carry pain signals from the hip.
The study included 40 adults aged 20-80 years undergoing planned hip surgery under general anesthesia at Cumhuriyet University Hospital. Participants were randomly assigned to two groups of 20. Before surgery, one group received a PENG block with bupivacaine, a local anesthetic. The other group received an injection of normal saline in the same location as a placebo. Participants and the clinicians assessing postoperative outcomes did not know which injection had been given.
After surgery, both groups received morphine through a patient-controlled pump. Pain scores, morphine consumption, the need for additional pain medication, and side effects including nausea, vomiting, and constipation were assessed over 24 hours.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's enrollment of 40 is below the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Cumhuriyet University is the lead sponsor of 133 studies on the registry; 26 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
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ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants received a single ultrasound-guided pericapsular nerve group (PENG) block after induction of general anesthesia and before surgical incision. Bupivacaine 1 mg/kg was diluted with 0.9% sodium chloride to a total volume of 30 mL. Postoperative analgesia was provided with intravenous patient-controlled morphine, and participants were followed for 24 hours.
Procedure: Ultrasound-Guided Pericapsular Nerve Group Block with Bupivacaine
Participants received a single ultrasound-guided injection of 30 mL of 0.9% sodium chloride at the same anatomical location used for the pericapsular nerve group (PENG) block, after induction of general anesthesia and before surgical incision. Postoperative analgesia was provided with intravenous patient-controlled morphine, and participants were followed for 24 hours.
Procedure: Ultrasound-Guided Placebo Injection with Normal Saline
A single ultrasound-guided pericapsular nerve group (PENG) block was performed after induction of general anesthesia and before surgical incision. Using an in-plane approach, bupivacaine 1 mg/kg diluted with 0.9% sodium chloride to a total volume of 30 mL was injected between the psoas tendon and the iliopubic eminence.
A single ultrasound-guided injection of 30 mL of 0.9% sodium chloride was administered at the same anatomical location as the PENG block, between the psoas tendon and the iliopubic eminence, after induction of general anesthesia and before surgical incision.
Cumulative Morphine Consumption During the First 24 Hours After Surgery
Total intravenous morphine consumption, measured in milligrams, delivered through the patient-controlled analgesia pump during the first 24 hours after surgery.
Time frame: First 24 hours after surgery
Postoperative Pain Intensity Assessed Using the Visual Analog Scale
Postoperative pain intensity was assessed using a 10-cm visual analog scale (VAS), ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain intensity.
Time frame: At 1, 2, 3, 4, 8, 16, and 24 hours after surgery
Time to First Rescue Analgesia
Time, measured in hours, from the end of surgery to the first requirement for rescue analgesia. Rescue analgesia was administered when the visual analog scale pain score exceeded 5.
Time frame: During the first 24 hours after surgery
Participants Requiring Rescue Analgesia
Number of participants requiring rescue analgesia during the first 24 postoperative hours. Rescue analgesia consisted of intravenous tramadol 100 mg and intravenous paracetamol 1000 mg when the visual analog scale pain score exceeded 5.
Time frame: During the first 24 hours after surgery
Incidence of Postoperative Nausea
Number of participants experiencing postoperative nausea during the first 24 hours after surgery.
Time frame: During the first 24 hours after surgery, assessed at 1, 2, 3, 4, 8, 16, and 24 hours
Incidence of Postoperative Vomiting
Number of participants experiencing postoperative vomiting during the first 24 hours after surgery.
Time frame: During the first 24 hours after surgery, assessed at 1, 2, 3, 4, 8, 16, and 24 hours
Incidence of Postoperative Constipation
Number of participants experiencing constipation during the first 24 hours after surgery.
Time frame: During the first 24 hours after surgery, assessed at 1, 2, 3, 4, 8, 16, and 24 hours
Postoperative Heart Rate
Heart rate, measured in beats per minute, at each postoperative assessment.
Time frame: At 1, 2, 3, 4, 8, 16, and 24 hours after surgery
Postoperative Mean Arterial Pressure
Mean arterial pressure, measured in mmHg, at each postoperative assessment.
Time frame: At 1, 2, 3, 4, 8, 16, and 24 hours after surgery
Patient Satisfaction
Patient satisfaction was assessed using four ordered categories: poor, fair, good, and very good. Categories toward very good indicate greater satisfaction.
Time frame: At 24 hours after surgery
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No — There is no plan to share individual participant data with other researchers.
Ran from Jul 2021 to primary completion in Jan 2022, 6 months.
Of 2,089 non-industry interventional studies with no phase under Pain, Postoperative, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 23. This study's 6 months is below that.
Counting every sponsor, half of 2,102 studies reached it within 11 months; a quarter within 6 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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