An interventional study of Incision and drainage + Povidone-iodine irrigation and Incision and drainage + ozonated distilled in Infection, Surgical Site, sponsored by Alexandria University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Alexandria University · Not applicable, Interventional, and Treatment
Maxillofacial space infections are among the most common infections encountered in oral and maxillofacial surgery and may progress to severe, life-threatening complications if not properly managed, making their treatment a critical component of maxillofacial surgical practice(1).In recent years, Ozonated distilled water has emerged as a promising alternative owing to its potent antimicrobial activity against bacteria, viruses, and fungi, while demonstrating minimal toxicity to host tissues.(2-3) Aim: thus, the aim of the present study is to investigate whether ozonated distilled water irrigation in patients experiencing facial space infection after surgical incision and drainage of the maxillofacial space infection would result in resolution of infection, reduction of postoperative pain and reduction of wound size.
692 studies on the registry are indexed under Surgical Wound Infection; 147 are open to participants now.
This study's planned enrollment of 26 is below the median of 200 across 530 interventional studies indexed under Surgical Wound Infection.
Browse Surgical Wound Infection studies →Alexandria University is the lead sponsor of 596 studies on the registry; 134 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Procedure: Incision and drainage + Povidone-iodine irrigation
Procedure: Incision and drainage + ozonated distilled
Patients suffering from suprahyoid maxillofacial space infections will be treated with incision and drainage and then daily irrigation using povidone-iodine together with empirical antibiotics.
Patients suffering from suprahyoid maxillofacial space infections will be treated with incision and drainage then daily irrigation using ozonated distilled water together with empirical antibiotics.
Reduction in wound size
Extraoral wound healing will be assessed using the Southampton Wound Assessment Scale (SWAS). 0: Normal healing 1. Normal healing with mild bruising and erythema. 2. Erythema and other signs of inflammation 3. Clear or serosanguinous discharge 4. Purulent discharge (pus) 5. deep wound infection
Time frame: up to 10 days
Change in pain scores
Numerical Rating score (NRS) will be used. The patients will be asked to choose the most appropriate number that describes their current pain. 1-3: Mild Pain (acceptable pain), 4-6: Moderate, 7-10: Severe Pain. Subjects will be asked to qualify the experienced pain as acceptable or not.
Time frame: up to 10 days
change in inflammatory biomarkers
Serial assessment of inflammatory biomarkers
Time frame: up to 7 days
Duration of drain placement
Number of days of drain placement will be recorded as an indicator of infection resolution and treatment response
Time frame: during the procedure
Start is estimated for Oct 2026; primary completion for Jan 2027, 3 months later.
Of 189 non-industry interventional studies with no phase under Surgical Wound Infection, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 52. This study's planned 3 months is below that.
Counting every sponsor, half of 196 studies reached it within 24 months; a quarter within 13 and three quarters within 52.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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