An observational study in Surgical Site Infection, Vaginal Cuff Cellulitis and Bacterial Vaginosis, sponsored by Baylor Research Institute. Enrolling by invitation at 1 site in United States. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by Baylor Research Institute · Observational
This study seeks to determine ways to reduce the hospitals surgical site infection rate during hysterectomy operations.
This is a retrospective review and prospective observational study involving a historical comparison which aims to compare the incidence of surgical site infection (SSI) from the time frame of January 2023 to June 2024, among approximately 900 hysterectomies who received traditional IV antibiotics, to a matched number of hysterectomies starting in December 2026. This study seeks to determine if a one-time dose of Xaciato postoperatively can reduce the hospitals vaginal cuff infections, to investigate effective means of preventing gynecologic SSI and to test for the presence of bacterial vaginosis (BV) causing pathogens after administration of pre-operative vaginal prep.
687 studies on the registry are indexed under Surgical Wound Infection; 142 are open to participants now.
This study's planned enrollment of 900 is above the median of 240 across 133 observational studies indexed under Surgical Wound Infection.
Browse Surgical Wound Infection studies →Baylor Research Institute is the lead sponsor of 223 studies on the registry; 49 are open to participants now.
Of its 23 completed or terminated interventional studies of FDA-regulated products, 9 (39%) have results posted.
Counted across the registry records on this site, refreshed daily.
Women, 18 years and older, receiving a hysterectomy
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Exclusion Criteria:
Women who are undergoing a hysterectomy will recieve a one-time dose of Xaciato after the operation to determine if it can reduce vaginal cuff infections.
Drug: Clindamycin Vaginal Gel
Vaginal clindamycin gel placed at the end of hysterectomy to prevent surgical site infection
Also known as: Xaciato
Surgical site infection
To investigate effective means of preventing gynecologic surgical site infection (SSI) following hysterectomy
Time frame: 30 days
Preventing vaginal cuff cellulitis
To investigate effective means of preventing vaginal cuff cellulitis following hysterectomy.
Time frame: 30 days
Bacterial Vaginosis
To test for the presence of BV causing pathogens after administration of pre-operative vaginal prep.
Time frame: 24 hours following surgery
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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