An interventional study of Scaling and Root Planing in Periodontitis, Clindamycin Gel and Aloe Vera Gel, sponsored by Suez Canal University. Completed at 1 site in Egypt. Open to participants aged 20 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-02.
Sponsored by Suez Canal University · Not applicable, Interventional, and Treatment
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes and reduce bacterial load. This study compared scaling and root planing alone with scaling and root planing combined with locally applied Aloe vera gel or clindamycin gel in adults with periodontitis. The study evaluated clinical periodontal parameters and anaerobic bacterial counts at baseline and at 1 and 3 months after treatment. The objective was to compare the clinical and microbiological outcomes of the three treatment approaches.
This single-blind, three-arm clinical study evaluated the clinical and microbiological outcomes of locally applied Aloe vera gel and clindamycin gel as adjuncts to nonsurgical periodontal therapy.
The study included 30 adults aged 20-45 years with periodontitis, comprising 10 participants in each treatment arm. Participants were selected from the Periodontology Clinic, Faculty of Dentistry, Suez Canal University, Egypt. All participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions.
The three treatment arms were scaling and root planing alone, scaling and root planing combined with local application of Aloe vera gel, and scaling and root planing combined with local application of 2% clindamycin gel. The gels were applied subgingivally into the periodontal pockets using a blunt syringe.
Clinical periodontal assessments included plaque index, gingival index, probing pocket depth, and clinical attachment level. Gingival crevicular fluid samples were collected for microbiological assessment of anaerobic bacterial counts using culture methods.
Clinical and microbiological assessments were performed at baseline and at 1 and 3 months after treatment. The study was approved by the Research Ethics Committee, Faculty of Dentistry, Suez Canal University (approval number 522/2022). Written informed consent was obtained from participants before study procedures.
1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.
This study's enrollment of 30 is below the median of 44 across 846 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Suez Canal University is the lead sponsor of 164 studies on the registry; 38 are open to participants now.
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Participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions. No adjunctive Aloe vera or clindamycin gel was applied.
Procedure: Scaling and Root Planing
Locally prepared Aloe vera gel was applied subgingivally into the periodontal pockets using a blunt syringe to fill the sulcus to its deepest point following scaling and root planing. The thesis describes Aloe vera leaf extract with hydroxypropyl methylcellulose and preservatives in the formulation.
Procedure: Scaling and Root Planing
Locally prepared 2% clindamycin gel was applied subgingivally into the periodontal pockets using a blunt syringe following scaling and root planing. The thesis describes a carboxymethylcellulose-based gel formulation.
Procedure: Scaling and Root Planing
Participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions.
Change in Clinical Attachment Level
Change in clinical attachment level (CAL), measured in millimeters from the cementoenamel junction to the base of the periodontal pocket. Measurements were obtained using a periodontal probe and a customized acrylic stent to improve reproducibility.
Time frame: Baseline, 1 month and 3 months after treatment.
Change in Probing Pocket Depth
Change in probing pocket depth (PPD), measured in millimeters from the free gingival margin to the base of the periodontal pocket using a UNC-15 periodontal probe and a customized acrylic stent.
Time frame: Baseline, 1 month and 3 months after treatment.
Anaerobic bacterial count
Change in anaerobic bacterial colony-forming units measured by culture of gingival crevicular fluid samples
Time frame: Baseline, 1 month, and 3 months
Change in plaque index score
Plaque Index (PI) Score, ranging from 0 to 3, with higher scores indicating a worse outcome (greater plaque accumulation).
Time frame: Baseline, 1 month, and 3 months
Change in gingival index score
Gingival Index (GI) Score, ranging from 0 to 3, with higher scores indicating a worse outcome (greater gingival inflammation).
Time frame: Baseline, 1 month, and 3 months
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Apr 2023 to primary completion in Aug 2026, 39 months.
Of 480 non-industry interventional studies with no phase under Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 31. This study's 39 months is above that.
Counting every sponsor, half of 494 studies reached it within 16 months; a quarter within 8 and three quarters within 31.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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