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Not yet recruitingNCT07888010Updated Oct 22, 2026

Dynamic Inflammatory Changes and Nutritional Risk Scores in ICU Patients Aged 65 Years and Older

An observational study in Critical Illness, Geriatric Patient and Mortality, sponsored by Ankara Etlik City Hospital. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.

Sponsored by Ankara Etlik City Hospital · Observational

Updated Oct 22, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
224
Ages
65 Years and older
Sex
All
01

Study summary

"This prospective observational study aims to evaluate the prognostic value of dynamic changes in the serum uric acid-to-albumin ratio (UAR) measured on admission (Day 0) and on Day 3, along with mNUTRIC and PNI scores, regarding 28-day mortality in intensive care patients aged 65 and older."

Read the detailed description

"As the elderly population in intensive care units (ICUs) continues to grow, identifying reliable and accessible prognostic markers for mortality becomes increasingly critical. This study is designed as a single-center, prospective observational cohort study conducted at Ankara Etlik City Hospital. A total of 224 patients aged 65 and older who stay in the ICU for at least 72 hours will be evaluated.

The primary objective is to investigate whether the dynamic changes in the Uric Acid-to-Albumin Ratio (UAR) between admission and the 3rd day of ICU stay-combined with nutritional and clinical risk scores such as mNUTRIC, PNI, APACHE II, and SOFA-can reliably predict 28-day all-cause mortality. Laboratory parameters, routine biochemistry, hemogram, and clinical outcomes including mechanical ventilation duration and total ICU length of stay will be systematically recorded."

02

Conditions studied

  • Critical Illness
  • Geriatric Patient
  • Mortality
  • Inflamation

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Keywords

  • Intensive care
  • mNUTRIC
  • Prognostic nutritional index
  • Uric acid to albumin ratio
03

In context

Critical Illness

1,923 studies on the registry are indexed under Critical Illness; 465 are open to participants now.

This study's planned enrollment of 224 is above the median of 130 across 883 observational studies indexed under Critical Illness.

Browse Critical Illness studies →

Lead sponsor

Ankara Etlik City Hospital is the lead sponsor of 172 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients aged 65 and older who were admitted to the intensive care units of Ankara Etlik City Hospital and followed for at least 72 hours.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Being 65 years of age or older
  • Having been followed up in the intensive care unit for at least 72 hours
  • Provision of written informed consent from the patient or their legal representative

Exclusion criteria

Exclusion Criteria:

  • Patients with terminal-stage malignancy
  • Chronic kidney disease of KDIGO stage 4 or higher
  • End-stage liver disease
  • Active hematological malignancy
  • Patients receiving immunosuppressive therapy
  • Patients with an active gout attack or using uric acid-lowering therapy
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
224 participants (estimated)
Patient registry
No

Groups and cohorts

  • Elderly ICU Patients

    Patients aged 65 and older who were hospitalized in the intensive care unit for at least 72 hours

    Other: Uric Acid to Albumin Ratio (UAR) and Nutritional Risk Scores

Interventions

  • OtherUric Acid to Albumin Ratio (UAR) and Nutritional Risk Scores

    Observational evaluation of biomarkers and clinical scores.

06

What researchers measure

Primary outcomes

  1. 28-day Mortality

    All-cause mortality evaluated up to 28 days following intensive care unit admission, and its prognostic relationship with the dynamic changes in serum uric acid-to-albumin ratio (UAR) between admission and Day 3, along with baseline mNUTRIC and PNI scores.

    Time frame: 28 days

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: Undecided — Individual participant data will not be shared due to institutional data privacy regulations and ethical restrictions regarding patient confidentiality.

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Nov 2026; primary completion for Jun 2027, 7 months later.

Of 473 non-industry observational studies under Critical Illness, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 43. This study's planned 7 months is below that.

Counting every sponsor, half of 477 studies reached it within 22 months; a quarter within 11 and three quarters within 43.

Critical Illness covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 15, 2026
First posted
Oct 22, 2026
StartEst.
Nov 1, 2026
Primary completionEst.
Jun 1, 2027
CompletionEst.
Jun 1, 2027
Last update
Oct 22, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 22, 2026
Show all 1 update
  1. Oct 22, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07888010
Responsible party
Saniye Kozan (resident doctor, Ankara Etlik City Hospital) — Principal investigator
First posted
Oct 22, 2026
Start date
Nov 1, 2026 (estimated)
Primary completion
Jun 1, 2027 (estimated)
Completion
Jun 1, 2027 (estimated)
Last update
Oct 22, 2026

Study contacts

saniye kozan, Research Assistant
Contact
saniyekoymen@hotmail.com
+905396650985

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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