An observational study in Epilepsies, sponsored by Istituto Giannina Gaslini. Recruiting at 23 sites in 13 countries. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Istituto Giannina Gaslini · Observational
This study will test computer programs that help doctors read brain MRI scans. The programs use artificial intelligence (AI). The study includes people with epilepsy, a condition that causes repeated seizures.
Brain changes linked to epilepsy can be hard to see on an MRI (magnetic resonance imaging) scan. Different doctors may read the same scan in different ways. The researchers want to build AI tools that help doctors find these changes earlier. Earlier findings could lead to a faster diagnosis. They could also help doctors decide if a genetic test or a brain surgery evaluation is right for a patient.
The researchers also want to learn if AI can predict how well epilepsy surgery will work. If it can, surgeons could use the tool to plan an operation. The goal is to stop seizures while protecting parts of the brain that control speech and sight.
Who can take part? People with epilepsy who are treated at the Gaslini Institute or another study center Adults who give their own written consent Children whose parent or caregiver gives written consent People who do not agree to take part cannot be included.
What will happen? The researchers will collect brain MRI scans from about 2,000 people. The scans come from regular clinical care.
The researchers will replace each person's name on the scan with a code number. The coded scans go to a secure online portal. Study centers around the world share this portal.
One trained researcher will run the AI programs on the scans. The researchers will keep the scans for 2 years to build an image library. The researchers will compare the scans with health information. They want to find signs in the scans that show how epilepsy may change over time.
This study does not test a new medicine or treatment. It will last about 2 years.
1,842 studies on the registry are indexed under Epilepsy; 423 are open to participants now.
This study's planned enrollment of 2,000 is above the median of 101 across 536 observational studies indexed under Epilepsy.
Browse Epilepsy studies →Istituto Giannina Gaslini is the lead sponsor of 50 studies on the registry; 33 are open to participants now.
Counted across the registry records on this site, refreshed daily.
People with epilepsy of any cause who are treated at participating centers worldwide. They have a brain MRI scan as part of routine clinical care. About 2,000 people will be enrolled consecutively. Some of them may later have epilepsy surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
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Exclusion Criteria:
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Create a large database of brain MRI scans from patients with epilepsy of various etiologies, referred to multiple highly specialized centers worldwide
Create a large database of brain MRI scans from patients with epilepsy of various etiologies, referred to multiple highly specialized centers worldwide
Time frame: Up to 24 months
Develop artificial intelligence (AI) algorithms that facilitate the detection of lesions on neuroimaging acquired during routine clinical practice
Develop artificial intelligence (AI) algorithms that facilitate the detection of lesions on neuroimaging acquired during routine clinical practice
Time frame: Up to 24 months
Implement the algorithms to predict outcomes in the subpopulation of patients who are eligible for, and undergo, epilepsy surgery.
Implement the algorithms to predict outcomes in the subpopulation of patients who are eligible for, and undergo, epilepsy surgery. Neurosurgeons will be able to use this computational tool to simulate and plan the surgical procedure with the best chance of curing the patient while preserving eloquent brain areas (e.g., language and visual areas).
Time frame: Up to 24 months
Plan to share: Undecided
No publications or documents are linked to this record.
Started May 2023 (actual). Primary completion is estimated for Dec 2026, 43 months after the start.
Of 190 non-industry observational studies under Epilepsy, half reached primary completion within 63 months of starting (the median), counting those still running; a quarter within 34 and three quarters within 179. This study's planned 43 months is below that.
Counting every sponsor, half of 228 studies reached it within 59 months; a quarter within 29 and three quarters within 119.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Istituto Giannina Gaslini