An observational study in Juvenile Idiopathic Arthritis (JIA), sponsored by Istituto Giannina Gaslini. Recruiting at 2 sites in Italy. Open to participants aged 2 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by Istituto Giannina Gaslini · Observational
This is a prospective-retrospective, translational, no profit, multicentric, observational study. A cohort of at least 100 early-onset JIA patients attending the Unit of Rheumatology and Autoinflammatory Diseases, Department of Pediatric Sciences, IRCCS Istituto Giannina Gaslini or selected Italian pediatric rheumatology centers, will be enrolled and evaluated at onset and at 5 time points of follow up to 24 months (month 3, month 6, month 12, month 18 and month 24) to monitor the course of the disease. A cohort of 30 patients with Iridocyclitis not correlated to JIA will be recruited in parallel at the time of disease diagnosis as a group of control for comparison.
Evaluations will include:
Collection of blood, urine, tears, and, in the case of joint infiltration, synovial fluid (SF) samples for carrying out the following analyses:
359 studies on the registry are indexed under Arthritis, Juvenile; 95 are open to participants now.
This study's planned enrollment of 130 is close to the median of 120 across 115 observational studies indexed under Arthritis, Juvenile.
Browse Arthritis, Juvenile studies →Istituto Giannina Gaslini is the lead sponsor of 50 studies on the registry; 33 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Pediatric patients followed in Italian centres specialised in Paediatric Rheumatic Diseases.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
For patients with JIA
For control subjects
Exclusion Criteria:
For patients with JIA
For control subjects
● Previous treatment with any synthetic or biologic DMARD before biologic sample collection.
Early-onset Juvenile Idiopathic Arthritis (JIA) represents the most common form of arthritis in Western country, affecting the 70-80% of Italian children. It typically occurs before the age of 6, has female predilection, high frequency of positive antinuclear antibodies (ANA),and is characterized by a high risk (20-30% of cases) of chronic iridocyclitis
Group of control for comparison.
Construction of an integrated multiparametric prediction model
In the 1st phase, data will be pre-processed to make them suitable to be analyzed by machine learning techniques (harmonized, filtered, imputed, and mapped). In the 2nd phase the most suitable machine learning approach will be designed. Model design will involve the selection of a suitable supervised learning approach such as multivariate time-series forecasting, and the identification of technical solutions to manage dataset sparseness, model overfitting, and class unbalancing. In the 3rd phase, the machine learning model will be implemented using open-source languages such as Python. Programming code will be tested in virtualized environment using synthetic and\\or real data collected in the previous phases of the project. In the 4th phase, the storage and computational resources will be acquired and set up to be employed. In the 5th phase, parts of the dataset will be randomly split in two groups. One group will be used to train the machine learning model and the second for testing.
Time frame: 24 months
Evaluation of parameters for the prediction of polyarticular extension
To evaluate the predictive ability of a wide range of clinical, ultrasound, genetic, multiomic, and immunological parameters for the prediction of polyarticular extension in patients with early-onset JIA.
Time frame: 24 months
Evaluation of parameters for the prediction of iridocyclitis
To evaluate the predictive ability and specificity of clinical, ultrasound, genetic, multiomic, and immunological parameters for the prediction of iridocyclitis development in patients with early-onset JIA.
Time frame: 24 months
Plan to share: Undecided
No publications or documents are linked to this record.
Started Jul 2024 (actual). Primary completion is estimated for Jul 2028, 48 months after the start.
Of 41 observational studies under Arthritis, Juvenile, half reached primary completion within 81 months of starting (the median), counting those still running; a quarter within 26 and three quarters within 186. This study's planned 48 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Istituto Giannina Gaslini