An interventional study of ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression. and The 'Health and Wellbeing in MS' website in Depression and Anxiety Symptoms and Multiple Sclerosis, sponsored by University of Melbourne. Not yet recruiting at 2 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by University of Melbourne · Not applicable, Interventional, and Treatment
Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons.
Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual.
The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.
8,240 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's planned enrollment of 240 is above the median of 84 across 6,869 interventional studies indexed under Depression.
Browse Depression studies →University of Melbourne is the lead sponsor of 86 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
8-week online depression intervention for people with MS
Device: ACTION-MS website - an 8-week cognitive behavioural therapy intervention for depression.
8-week online health and wellbeing in MS informational intervention.
Device: The 'Health and Wellbeing in MS' website
The CBT-based online intervention is designed for people with multiple sclerosis who are experiencing mild to moderate depression. There are 8 modules which include (1) Introduction; (2) Managing depressive and anxiety symptoms: Part 1; (3) Managing depressive and anxiety symptoms: Part 2; (4) Practice challenging unhelpful thoughts; (5) Managing fatigue and pain; (6) Sleep hygiene; (7) Problem Solving; (8) Preventing relapse of depressive and anxiety symptoms.
The 'Health and Wellbeing in MS' website contains health information related to MS. There are 8 sections of the website with each section focusing on a different topic. Each section includes information and some key evidence from current research about the topic. The 8 sections are: (1) Nutrition and diet; (2) Gut health and microbiome; (3) Supplements; (4) Vitamin D and sun exposure; (5) Lipids and MS; (6) Weight and obesity; (7) Smoking; (8) Other health conditions and MS.
Depression, measured on Beck's Depression Inventory II
Time frame: Baseline, post intervention (8 weeks) and 28-weeks follow up
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Melbourne