An interventional study of Test facial cream (topical skin care product) in Facial Photoaging, Deepening of Facial Wrinkles and Skin Laxity, sponsored by ChinaNorm. Completed at 1 site in China. Open to female participants aged 25 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-14.
Sponsored by ChinaNorm · Not applicable, Interventional, and Treatment
The goal of this study is to evaluate the anti-wrinkle, firming, moisturizing and repairing efficacy of a test facial cream after single use and 12 weeks of continuous use via clinical evaluation, instrumental measurement, image analysis and participant self-assessment.
The main questions it aims to answer are:
Does the test cream produce immediate anti-wrinkle, firming, moisturizing and repairing effects on facial skin after single use? Can 12-week continuous use of the test cream sustainably improve facial skin condition in terms of wrinkles, laxity, hydration and skin repair? This is a single-center clinical study with a self-controlled before-and-after design. Around 70 healthy Chinese women aged 25-50 will be randomly divided into an instrumental group and a questionnaire group, with no fewer than 40 valid clinical test samples and 60 valid questionnaire samples. The study uses four products, including one test cream and three auxiliary skincare products.
Participants will:
Use the test cream once on-site and continuously at home for 12 weeks with matched auxiliary products.
Attend six scheduled visits at key time points: 2 weeks before product use for washout and screening (T-2W), baseline detection and immediate assessment after single product use (T0+Timm), 1 week after continuous product use (T1W), 4 weeks after continuous product use (T4W), 8 weeks after continuous product use (T8W), and 12 weeks after continuous product use (T12W) .
Complete group-specific assessments: the instrumental group will undergo instrumental tests, clinical evaluation and image collection; the questionnaire group will finish clinical screening and self-assessment.
Receive skin indicator detection and efficacy evaluation at all designated time points to verify the product's skincare effects.
151 studies on the registry are indexed under Cutis Laxa; 36 are open to participants now.
This study's enrollment of 70 is above the median of 30 across 133 interventional studies indexed under Cutis Laxa.
Browse Cutis Laxa studies →ChinaNorm is the lead sponsor of 28 studies on the registry; 12 are open to participants now.
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1) Chinese female aged from 25 to 50. 2) All skin types, 50% self-declared sensitive skin. 3) Skin type II to IV according to Fitzpatrick classification. 4) Presenting with dull skin, lack of radiance, brightness, transparency on face evaluated by dermatologist.
5) Presenting with sagging, elasticity, plumpness, softness, fine line and wrinkles on face evaluated by dermatologist.
6) Presenting with corresponding severity for the attribute on face evaluated by dermatologist.
Horizontal Neck Folds: Atlas scale, 1≤grade≤6 7) Did not participate in any clinical test or cosmetic product test on skin within 3 months.
8) No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer. 9) In general, good health at the time of the study. 10) Willing and able to participate as evidenced by signing of informed consent \& photo release form.
11) Must be willing to comply with all study protocol requirements.
Exclusion Criteria:
1) Pregnant or breast-feeding woman or woman planning pregnancy during the study.
2) Subject deprived of rights by a court or administrative order. 3) Major subject to a guardianship order. 4) Subject residing in a health or social care establishment. 5) Subject in an emergency setting. 6) Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
7) Subject presenting a stable or progressive serious disease (per investigator's assessment). 8) Immuno-compromised subject. 9) Subject with history of allergy to cosmetic or personal care products or ingredients.
10) Subject with history of allergy to metal. 11) Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
12) Subject with history of sunlight sensitivity or allergies. 13) Subjects regularly practicing aquatic or nautical sports. 14) Subjects regularly attending a sauna. 15) Subject with physical highly sensitive constitution. 16) Subject with cardiovascular or circulatory history. 17) Subject with a history of skin cancer or malignant melanoma. 18) Subject with history of medical beauty treatment and taking part in anti-aging studies in the last 3 months before study.
19) Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.
All participants apply the same test facial cream. Subjects are randomly assigned to either instrumental assessment subgroup or questionnaire subgroup for different outcome measurements. Skin efficacy indicators are evaluated at baseline, immediately after single use, 1,4,8 and 12 weeks of continuous use.
Other: Test facial cream (topical skin care product)
Topical test facial cream for facial skin application. Participants apply the cream once on-site and then use it daily at home for 12 consecutive weeks, together with assigned auxiliary skin care products. The study evaluates anti-aging efficacy including wrinkles, skin laxity and elasticity.
Change from baseline in dermatologist clinical scoring of facial skin attributes
Dermatologist clinical assessment scoring of cheek sebaceous pores, skin dullness, skin redness, skin radiance, skin brightness, skin plumpness, fine lines, skin firmness, skin elasticity, skin softness, skin smoothness, skin translucency, facial sagging, nasolabial fold, forehead wrinkles, glabellar wrinkles, crow's feet wrinkles, lip corner wrinkles, under-eye wrinkles, inter-ocular wrinkles and horizontal neck folds.
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in facial imaging parameters
Facial and local skin images captured by Visia-CR Gen5, Capture Frame \& Digital Camera, Ultrascan UC22, Primos CR and Two-photon Microscopic Imaging System (SUPERVERSION 780).
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in skin hydration
Skin hydration measured by Corneometer on facial skin.
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in transepidermal water loss (TEWL)
Transepidermal water loss (TEWL) measured by Vapometer on facial skin
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Change from baseline in subject self-assessment questionnaire
Subject self-evaluation of skin condition completed via consumer questionnaire.
Time frame: Baseline (prior to test product use), 1 week after starting test product use, 4 weeks after starting test product use, 8 weeks after starting test product use, 12 weeks after starting test product use
Plan to share: No
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This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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