An interventional study of lower frequency of assessment of neurological impairment and vital signs and standard frequency of assessment of neurological impairment and vital signs in Stroke, Ischemic, sponsored by Shengjing Hospital. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-08.
Sponsored by Shengjing Hospital · Not applicable, Interventional, and Supportive care
This cluster-randomized study compares a lower-frequency post-thrombolysis monitoring pathway with a standard pathway in adults with acute ischemic stroke. The study evaluates nursing workload, nursing care, and clinical safety during the early post-thrombolysis period.
Intravenous thrombolysis is an established reperfusion treatment for eligible patients with acute ischemic stroke, but post-thrombolysis monitoring is resource intensive. This study will evaluate whether a lower scheduled monitoring frequency can reduce nursing workload without causing a clinically important increase in missed nursing care or compromising clinical safety. Hospitals will be randomized in a 1:1 ratio to a low-intensity monitoring pathway or a standard-intensity monitoring pathway.
2,593 studies on the registry are indexed under Ischemic Stroke; 930 are open to participants now.
This study's planned enrollment of 864 is above the median of 120 across 1,752 interventional studies indexed under Ischemic Stroke.
Browse Ischemic Stroke studies →Shengjing Hospital is the lead sponsor of 125 studies on the registry; 58 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants at assigned hospitals will receive a reduced scheduled nursing monitoring pathway during the first 24 hours after intravenous thrombolysis. Additional assessment or clinical escalation is permitted when indicated.
Procedure: lower frequency of assessment of neurological impairment and vital signs
Participants at assigned hospitals will receive the study standard scheduled nursing monitoring pathway during the first 24 hours after intravenous thrombolysis. Additional assessment or clinical escalation is permitted when indicated.
Procedure: standard frequency of assessment of neurological impairment and vital signs
Participants receive neurological assessment and heart rate/blood pressure assessment every 15 minutes during the first 2 hours after initiation of thrombolytic infusion, every 2 hours during the next 8 hours, and every 4 hours during the subsequent 14 hours. Additional clinically indicated monitoring is permitted and required.
Participants receive neurological assessment and heart rate/blood pressure assessment every 15 minutes during the first 2 hours after initiation of thrombolytic infusion, every 30 minutes during the subsequent 6 hours, and every 60 minutes during the subsequent 16 hours. Additional clinically indicated monitoring is permitted and required.
Objective Nursing Workload
Time frame: From baseline to 24 hours: total time spent on post-thrombolysis nursing monitoring activities, recorded in minutes per participant.
Missed Nursing Care
Time frame: During index hospitalization, up to 7 days, using MISSCARE Survey.
No study locations are listed for this record.
Plan to share: Undecided
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Shengjing Hospital