An observational study in Vestibular Schwannoma, sponsored by Shengjing Hospital. Enrolling by invitation at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Shengjing Hospital · Observational
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular schwannoma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for risk stratification and prediction of tumor behavior, and to evaluate the relationship between MRE characterization of tumor mechanical features and patients' clinical prognosis.
Vestibular schwannomas are the most common tumors in the cerebellopontine angle and are generally amenable to microsurgical resection. However, the intraoperative biomechanical characteristics of these tumors, particularly their stiffness and adhesion to adjacent neurovascular structures, vary considerably among patients and have a direct impact on surgical difficulty, extent of resection, postoperative complications, and functional outcomes. Current preoperative imaging modalities provide limited information regarding these biomechanical properties, making it difficult to accurately predict surgical complexity and facilitate individualized surgical planning and preoperative patient counseling.
This prospective clinical study aims to evaluate the feasibility and clinical value of three-dimensional magnetic resonance elastography (3D MRE) for the preoperative assessment of vestibular schwannomas. Specifically, quantitative MRE-derived biomechanical parameters, including tumor stiffness and adhesion-related characteristics based on shear modulus maps, will be compared with intraoperative surgeon-assessed tumor stiffness, adhesion, vascularity, surgical difficulty, and postoperative histopathological findings. In addition, postoperative facial nerve function will be longitudinally evaluated to investigate the association between preoperative MRE findings and functional prognosis.
Approximately 30 patients with radiologically confirmed vestibular schwannomas who are scheduled to undergo elective microsurgical resection will be prospectively enrolled. All participants will receive routine preoperative MRI together with an additional 3D MRE examination. During surgery, standardized assessments of tumor stiffness, adhesion to surrounding structures, vascularity, and resection difficulty will be recorded by the operating neurosurgeons. Postoperative clinical follow-up will include facial nerve function assessment and collection of other relevant clinical outcome measures.
Statistical analyses will be performed to evaluate the correlations between MRE-derived biomechanical parameters and intraoperative findings, histopathological features, and postoperative outcomes, as well as to assess the diagnostic performance and prognostic value of 3D MRE.
Findings of this study are expected to establish 3D MRE as a noninvasive imaging biomarker for the preoperative characterization of vestibular schwannomas, thereby improving surgical planning, enhancing patient counseling, reducing perioperative complications, and ultimately optimizing clinical decision-making.
This study will enroll adult patients with unilateral sporadic vestibular schwannoma who are scheduled to undergo microsurgical resection at Shengjing hospital.
Exclusion Criteria:
Participants in this group will undergo preoperative three-dimensional magnetic resonance elastography (3D MRE) . MRE will be used to quantify tumor stiffness and generate a three-dimensional adhesion map. The facial nerve function after surgery will be followed up 3 - 6 months after the operation.
Agreement Between MRE Stiffness and Intraoperative Tumor Consistency
The primary outcome is the correlation between preoperative 3D MRE-derived shear stiffness values and intraoperative tumor consistency as assessed by the neurosurgeon using a standardized ordinal scale (1-5). Agreement will be evaluated using Spearman correlation and Bland-Altman analysis.
Time frame: Intraoperative (Day of Surgery)
Plan to share: No
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Shengjing Hospital