An interventional study of Sustained Isometric Handgrip Exercise and Semi-Supine Bicycle Exercise in Heart Failure, sponsored by Norwegian University of Science and Technology. Not yet recruiting at 1 site in Norway. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Norwegian University of Science and Technology · Not applicable, Interventional, and Basic science
Noninvasive left ventricular pressure-strain loop analysis estimates myocardial work from longitudinal strain, brachial systolic blood pressure, and cardiac valve-event timing. It provides global work index, constructive work, wasted work, and work efficiency.
This study evaluates a deep-learning method that automates myocardial work and loop-shape analysis. The method may reduce analysis time, improve reproducibility, and identify patterns associated with heart failure.
Heart failure participants:
Healthy volunteers:
Exclusion Criteria:
Heart failure participants:
Healthy volunteers:
Participants undergo echocardiography at rest, during sustained handgrip, and during semi-supine bicycle exercise.
Behavioral: Sustained Isometric Handgrip Exercise · Behavioral: Semi-Supine Bicycle Exercise
Healthy volunteers undergo echocardiography at rest, during sustained handgrip, and during semi-supine bicycle exercise.
Behavioral: Sustained Isometric Handgrip Exercise · Behavioral: Semi-Supine Bicycle Exercise
Participants perform sustained isometric handgrip at around 30 % of maximal voluntary contraction for 5 minutes during echocardiography.
Participants perform graded semi-supine bicycle exercise during echocardiography.
Echocardiographic Acquisition Success
Percentage of acquired examinations successfully processed by the deep-learning pipeline to generate myocardial work indices, assessed separately at rest, during handgrip, and during bicycle exercise.
Time frame: During one study visit: at rest, during the handgrip and bicycle test.
Agreement Between Deep Learning- and Expert-Derived Myocardial Work Indices
Agreement for myocardial work indices will be assessed using mean bias with 95% limits of agreement, and mean absolute error.
Time frame: Echocardiograms acquired at rest and during handgrip and bicycle exercise at a single study visit.
Plan to share: No — Individual participant data sharing is not currently planned. Any future sharing would require appropriate ethical, institutional, and data-protection approvals.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Norwegian University of Science and Technology