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CompletedNCT07849790USC TCORS P4Updated Oct 5, 2026

Social Media Influences on Perceptions of Alternative Nicotine and Nicotine-like Vaping Products Among Youth and Young Adults (AYA)

An interventional study of An image resembling a social media post in Vaping, sponsored by University of Southern California. Completed at 1 site in United States. Open to participants aged 14 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-05.

Sponsored by University of Southern California · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Registered 1 year 1 month after the study started (first participant enrolled Aug 2025, registered Sep 2026).
Updated Oct 5, 2026Eligibility revisedInterventions changed+1 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
2,829
Allocation
Randomized
Ages
14 Years to 25 Years
Sex
All
01

Study summary

The purpose of this study is to present images featuring various alternative nicotine and nicotine-like vaping products to assess adolescents' and young adults' harm and appeal perceptions of, and susceptibility to use these products, as well as to assess whether these perceptions and susceptibility are moderated by participants' age, sex at birth, race and ethnicity, nicotine and non-nicotine current use, and exposure to nicotine and tobacco product content on social media.

Read the detailed description

This randomized online survey-based experiment was aimed to be conducted among a national sample of U.S. adolescents and young adults recruited by an online panel Cint. Participants viewed three images of flavored disposable vaping products in one of four conditions: synthetic/tobacco-free nicotine, zero-nicotine, ambiguous nicotine ("clean"/ "pure"), or tobacco nicotine (control). After each image harm and appeal perceptions, and susceptibility/intention to use these products, as well as interactions of the experimental conditions with participants' age, sex at birth, race and ethnicity, nicotine and non-nicotine current use, and exposure to nicotine and tobacco product content on social media. Generalized estimating equation models assessed the associations between the experimental conditions and the outcomes.

02

Conditions studied

  • Vaping

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Keywords

  • nicotine
  • nicotine analogues
  • nicotine-free
  • tobacco-free
  • social media
03

In context

Vaping

160 studies on the registry are indexed under Vaping; 72 are open to participants now.

This study's enrollment of 2,829 is above the median of 110 across 135 interventional studies indexed under Vaping.

Browse Vaping studies →

Lead sponsor

University of Southern California is the lead sponsor of 773 studies on the registry; 135 are open to participants now.

Of its 68 completed or terminated interventional studies of FDA-regulated products, 32 (47%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
14 Years to 25 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • being able to complete the online survey in English
  • provides parental consent and youth assent or adult consent

Exclusion criteria

Exclusion Criteria:

  • younger than 14 or older than 25
  • no parental consent and youth assent or adult consent
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Factorial assignment
Masking
None (open label)
Enrollment
2,829 participants (actual)

Study arms

  • Active comparator
    an image depicting a tobacco nicotine vaping product

    an image resembling a social media post

    Behavioral: An image resembling a social media post

  • Experimental
    an image depicting a zero-nicotine vaping product

    an image resembling a social media post

    Behavioral: An image resembling a social media post

  • Experimental
    an image depicting an ambiguous nicotine vaping product

    an image resembling a social media post

    Behavioral: An image resembling a social media post

  • Experimental
    an image depicting a synthetic/tobacco-free nicotine vaping product

    an image resembling a social media post

    Behavioral: An image resembling a social media post

Interventions

  • BehavioralAn image resembling a social media post

    The images varied by 4 conditions, to which participants were randomly assigned. Each participant viewed three images of flavored disposable vaping products presented in random order in one of the following four randomly assigned conditions: synthetic/tobacco-free nicotine, zero-nicotine, ambiguous nicotine ("clean"/ "pure"), or tobacco nicotine (control).

06

What researchers measure

Primary outcomes

  1. Harm perceptions of vaping to one's own health

    How harmful do you think vaping this product is to your health? assessed on a 5-point ordinal scale (1 = Not at all harmful; 5= extremely harmful)

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  2. Harm perceptions of vaping to others' health

    and How harmful do you think vaping this product is to others' health? assessed on a 5-point ordinal scale (1 = Not at all harmful; 5= extremely harmful)

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  3. Appeal perceptions of vaping

    Vaping this product is: not cool/cool, assessed with 7-point semantic differential scales.

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  4. Appeal perceptions of vaping

    Vaping this product is: not fun/fun, assessed with the 7-point semantic differential scales

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  5. Appeal perceptions of vaping

    Vaping this product is: unattractive/attractive, assessed with 7-point semantic differential scales

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  6. Susceptibility to vaping product use

    If one of your best friends offered you this vape device, would you vape it?, assessed with a 4-point scale "definitely not," "probably not," "probably yes," "definitely yes"

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  7. Susceptibility to vaping product use

    Do you think you might use a vape device like this in the next year?, assessed with a 4-point scale "definitely not," "probably not," "probably yes," "definitely yes"

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  8. Susceptibility to vaping product use

    Do you think you might use a vape device like this soon?, assessed with a 4-point scale "definitely not," "probably not," "probably yes," "definitely yes"

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

  9. Susceptibility to vaping product use

    Are you curious about vaping this device?, assessed with a 4-point scale "definitely not," "probably not," "probably yes," "definitely yes"

    Time frame: Assessed 3 times immediately after each of the 3 images during the 5-minute-long online survey-based experiment

07

Study locations

1 site
  • University of Southern California
    Los Angeles, California 90032, United States
08

References and documents

Individual participant data

Plan to share: No — There is no need to share IPD with other researchers.

09

Updates

2 registry updates since Sep 25, 2026
Also revised
eligibility and interventions
Registered
First appeared on the registry
Sep 30, 2026
Show all 2 updates
  1. Oct 5, 2026
    Eligibility Criteria revised
    Interventions Arms or interventions changed
    + 5 other changes: index terms, identifiers, description, conditions and design details
  2. Sep 30, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07849790
Lead sponsor
University of Southern California
Responsible party
Jennifer Unger (Professor, University of Southern California) — Principal investigator
First posted
Sep 30, 2026
Start date
Aug 20, 2025
Primary completion
Aug 31, 2025
Completion
Aug 31, 2025
Last update
Oct 5, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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