An observational study in Complex Regional Pain Syndrome (CRPS), sponsored by Walton Centre NHS Foundation Trust. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Walton Centre NHS Foundation Trust · Observational
Complex regional pain syndrome (CRPS) is a very painful condition that can have a huge impact on people's lives. Despite progress having been made in understanding what CRPS is and how it affects people, there are still many questions that remain unanswered. Research plays an important role in helping healthcare professionals understand illness and develop new treatments. The purpose of this study is to contribute to understanding of CRPS, specifically by seeing whether there are links between CRPS and other chronic pains. A study done at the Walton Centre in the past suggested that there may be some links, which the investigators will re-examine in this study in more detail, as well as asking other important questions which may bring new information to light.
This cross-sectional study will use a questionnaire-based method to gather information on pre-existing pain, before CRPS development, at the same site where CRPS then develops, and on additional pain (pre-existing or later developing) from a large cohort of patients with CRPS. This will allow a large amount of data to be collected in a time-efficient manner and enable comparison between different groups, for example, those who developed widespread pain before or after their diagnosis of CRPS. The investigators know from existing research that widespread pain is a relatively common phenomenon in patients with CRPS; on this basis they expect its frequency in the cohort to be such that they may be able to detect statistically significant patterns in its development, for example a different frequency in certain age groups. Thus the questionnaire will feature questions about the patient's CRPS diagnosis and any additional pain they have experienced, including its time course of development and nature. It will also include questions about other symptoms that are more commonly observed in chronic widespread pain than in CRPS, such as cognitive symptoms and sleep disturbance, and which form part of the ACR 2016 criteria for fibromyalgia syndrome diagnosis. Independently, given the unexpected finding of CRPS-preceding pains in the later CRPS-affected limb in a previous Walton Centre study, the investigators will also more systematically evaluate this phenomenon.
206 studies on the registry are indexed under Complex Regional Pain Syndromes; 55 are open to participants now.
This study's enrollment of 705 is above the median of 58 across 44 observational studies indexed under Complex Regional Pain Syndromes.
Browse Complex Regional Pain Syndromes studies →Walton Centre NHS Foundation Trust is the lead sponsor of 17 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
People with CRPS first seen in outpatient clinic by Walton Centre Pain consultants between 2007 and 2023, who had consented to have their data entered into the Walton Centre CRPS database
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Frequency and nature of chronic pain preceding CRPS onset, and additional pain development in patients with CRPS
Bespoke questionnaire tracking preceding pain location and intensity prior to CRPS, initial CRPS location and intensity and impact and pain following CRPS diagnosis. Included EQ-5D-5L questionnaire to track current overall quality of life.
Time frame: From date recorded by patient of first preceding pain / CRPS diagnosis, to date questionnaire received by patient. Expected time frame from this of 1-20 years based on patient response.
Ran from Oct 2024 to primary completion in Jun 2025, 8 months.
Completion moved once since we started tracking on Sep 25, 2026: Sep 2026 → Oct 2026, on Oct 13, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Complex Regional Pain Syndromes →
Walton Centre NHS Foundation Trust