An observational study in Acute Kidney Injury, sponsored by Karolinska Institutet. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Karolinska Institutet · Observational
This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden. Using data from the Swedish Intensive Care Registry, the study will assess whether the Clinical Frailty Scale (CFS) and other measures of comorbidity and illness severity provide prognostic information beyond chronological age. Outcomes will include 30-day mortality, intensive care unit length of stay, and mortality at 60, 90, and 365 days following intensive care unit (ICU) admission. The study aims to contribute to more individualized assessment of critically ill patients who may require CRRT.
This is a nationwide, registry-based observational cohort study of critically ill patients treated in intensive care units in Sweden. The study will use data from the Swedish Intensive Care Registry (SIR), which collects information from intensive care units across Sweden.
The primary focus is on critically ill patients receiving continuous renal replacement therapy (CRRT), with particular emphasis on older patients and the prognostic role of frailty. The study will investigate whether the Clinical Frailty Scale (CFS) and measures of comorbidity and illness severity provide prognostic information beyond chronological age.
The cohort will include eligible adult intensive care unit patients receiving continuous renal replacement therapy during their ICU stay. Baseline characteristics, including age and sex, will be assessed at ICU admission. Illness severity will be described using the Simplified Acute Physiology Score 3 (SAPS3), including estimated mortality risk. Additional variables will include comorbidities, ICU admission characteristics, discharge diagnosis, and CRRT-related treatment information available in the registry.
Mortality follow-up will be conducted through available registry data and linkage to the Swedish Cause of Death Register. Outcomes will be assessed at predefined time points, including 30, 60, 90, and 365 days following intensive care unit admission.
The study is observational and registry-based. Investigators will not assign continuous renal replacement therapy treatment or perform research procedures on patients. Statistical analyses will include descriptive methods, survival analyses, and multivariable regression to evaluate associations between frailty, age, illness severity, and clinical outcomes.
1,691 studies on the registry are indexed under Acute Kidney Injury; 395 are open to participants now.
This study's planned enrollment of 22,000 is above the median of 160 across 814 observational studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Karolinska Institutet is the lead sponsor of 1,148 studies on the registry; 276 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The criteria were revised on the registry on Sep 28, 2026. See what changed
Adult patients (aged ≥18 years) admitted to Swedish intensive care units and receiving continuous renal replacement therapy (CRRT) during their ICU stay between January 1, 2012, and August 15, 2024. Patients will be identified through the Swedish Intensive Care Registry (SIR). The study focuses on the association between age, frailty, illness severity, and clinical outcomes, including mortality and ICU length of stay. Clinical Frailty Scale data will be used when available, with mortality follow-up for up to 365 days after ICU admission.
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Exclusion Criteria:
Critically ill patients with AKI and need for (the intervention) CRRT
30-day mortality
All-cause mortality assessed following ICU admission using mortality data available through the Swedish Intensive Care Registry and registry linkage.
Time frame: Within 30 days after ICU admission.
Intensive care unit length of stay
Duration of ICU stay, assessed using registry data.
Time frame: During the index ICU admission.
60-day mortality
60-day all-cause mortality following ICU admission.
Time frame: Within 60 days after ICU admission.
90-day mortality
All-cause mortality following ICU admission.
Time frame: Within 90 days after ICU admission.
365-day mortality
All-cause mortality following ICU admission
Time frame: Within 365 days after ICU admission.
No study locations are listed for this record.
Plan to share: No — Individual participant data will not be made publicly available because the study uses sensitive registry data obtained from the Swedish Intensive Care Registry and national Swedish health and population registers. Data sharing is subject to applicable ethical approvals, data protection legislation, and the terms and conditions of the relevant data controllers. Aggregated results may be shared through scientific publications and presentations.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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