ClinicalTrials.gg
CompletedNCT07837167prp vs VIUUpdated Sep 23, 2026

The Effect of Platelet Rich Plasma Injection on Post Internal Urethrotomy Stricture Recurrence

A Phase 3 interventional study of PRP injection and VIU in Stricture Urethra, sponsored by Benha University. Completed at 1 site in Egypt. Open to male participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-09-23.

Sponsored by Benha University · Phase 3, Interventional, and Treatment

From the registry’s dates

  • Registered 2 years 6 months after the study started (first participant enrolled Feb 2024, registered Sep 2026).
Phase
Phase 3
Study type
Interventional
Enrollment
156
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
Male
01

Study summary

The effect of platelet rich plasma injection on post internal urethrotomy stricture recurrence

02

Conditions studied

  • Stricture Urethra

Browse trials for

03

In context

Urethral Stricture

72 studies on the registry are indexed under Urethral Stricture; 25 are open to participants now.

This study's enrollment of 156 is above the median of 60 across 56 interventional studies indexed under Urethral Stricture.

Browse Urethral Stricture studies →

Lead sponsor

Benha University is the lead sponsor of 362 studies on the registry; 66 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
Male
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patients with symptomatic bulbar urethral stricture (diagnosed by retrograde urethrography) aged between 20 and 50 years.

Exclusion criteria

Exclusion Criteria:

  • History or medical evidence of symptomatic benign prostatic enlargement.
  • documented or suspicious prostate cancer.
  • history of hypospadias, neurogenic disorders.
  • previous internal urethrotomy or urethral reconstruction.
  • strictures longer than 1.5 cm.
  • multiple strictures.
05

Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
156 participants (actual)

Study arms

  • Active comparator
    PRP in stricture urethra

    Drug: PRP injection

  • Placebo comparator
    viu in stricture urethra

    Procedure: VIU

Interventions

  • The effect of platelet rich plasma injection on post internal urethrotomy stricture recurrence

  • ProcedureVIU

    VIU in stricture urethra

06

What researchers measure

Primary outcomes

  1. Post-voiding residual urine volume (PVR)

    Post-voiding residual urine volume will be measured by ultrasonography , Unit of Measure : ml .

    Time frame: 2 weeks

  2. Maximum urinary flow rate (Qmax)

    Maximum urinary flow rate will be assessed by uroflowmetry , Unit of Measure : ml/second

    Time frame: 2 weeks

Secondary outcomes

  1. recurrence of stricture urethra

    recurrence of stricture urethra measured by ascending urethrogram and uroflowmetry

    Time frame: 2 years

07

Study locations

1 site
  • Mostafa Ali Mahmoud
    Banhā, Qalyubia Governorate 13111, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07837167
Lead sponsor
Benha University
Responsible party
Mostafa Ali Mahmoud (urology lecturer , urology department ,principal investigator ,benha university, Benha University) — Principal investigator
First posted
Sep 23, 2026
Start date
Feb 19, 2024
Primary completion
Feb 19, 2025
Completion
Mar 19, 2026
Last update
Sep 23, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Studies of the drug tested here: Platelet rich plasma

Start the discussion