An interventional study of Supervised Physical Activity Program in Obesity & Overweight and Depression Disorders, sponsored by Universite du Quebec en Outaouais. Not yet recruiting at 3 sites in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Universite du Quebec en Outaouais · Not applicable, Interventional, and Other
Among 574 studies in Obesity with a site in Canada — 101 open to participants now, 150 under way, 46 of them phase 3. Obesity · Canada.
Among the 574 studies in Obesity with a site in Canada, this one is the 394th largest by planned enrollment of the 479 interventional ones, is one of 2 that started in 2027, is one of 280 with no phase, reaches primary completion later than 93 of the 149 other live ones, and was the 567th registered.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 26 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →101 of the 574 studies in Obesity with a site in Canada are open now, in 12 countries. Each count lists the studies.
Of the 1,336 Obesity studies recruiting now, 377 (28%) set no upper age limit and 856 (64%) stop at 75 or younger; 168 take children under 18; 491 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →574 studies; the count open now beside each. This study's row is marked.
First in 1997; this study’s year is marked. 2 started in 2027.
Median enrollment 73 across the 479 interventional studies, 52 across the 91 observational. Of the 362 that completed or were terminated, 48 (13%) have results posted.
162 of 574 have an industry lead sponsor. The 10 most frequent:
Universite du Quebec en Outaouais is the lead sponsor of 11 studies on the registry; 4 are open to participants now.
Universite du Quebec en Outaouais has 3 studies filed under Obesity — fewer than ten, so there is no comparison to draw.
46 of the studies in Obesity with a site in Canada that are under way reach primary completion within a year, 12 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06962280Phase 3Eli Lilly and CompanyA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight | 2026-11 |
| NCT06858839Phase 3AmgenEvaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT06858878Phase 3AmgenEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT07220642Phase 3Novo Nordisk A/SWeight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide | 2027-05-11 |
| NCT07220759Phase 3Novo Nordisk A/SWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide | 2027-05-12 |
Among the 574 studies in Obesity with a site in Canada, from their registry updates:
The goal of this clinical trial is to learn whether a supervised physical activity program can be successfully carried out for adults living with obesity and depression, and whether people are willing to take part in this kind of research. The main questions it aims to answer are:
Can researchers recruit enough participants and keep them in the study? Will participants attend the physical activity sessions? Does physical activity change how depression symptoms are connected to each other over time?
Researchers expect that the study procedures and the physical activity program will be feasible and acceptable, based on goals set before the study began. Researchers also expect that physical activity will weaken the connections between depression symptoms over time and will lower depression symptoms overall. This second idea will be tested more fully in a future, larger trial.
Researchers will compare a supervised physical activity program to usual care to see whether the program can be delivered as planned and is acceptable to participants.
Participants will:
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will take part in an individually supervised physical activity program led by a trained kinesiologist, consisting of two 45-minute sessions per week for 9 weeks. The program will include aerobic activities (e.g., kickboxing, walking, running) and resistance exercises, selected based on each participant's preferences to support adherence. Participants will choose their preferred location (research center, community room, or outdoor park). Exercise intensity will be self-selected by participants during the first two weeks, then gradually progressed toward a moderate intensity target (50-60% of heart rate reserve), monitored using a heart rate monitor at each session.
Other: Supervised Physical Activity Program
Participants will continue their usual care and will receive written documentation on the benefits of physical activity, along with information about community organizations offering physical activity and mental health resources. No supervised exercise program will be provided to this group.
Participants will take part in an individually supervised physical activity program led by a trained kinesiologist, consisting of two 45-minute sessions per week for 9 weeks. The program will include aerobic activities (e.g., kickboxing, walking, running) and resistance exercises, selected based on each participant's preferences to support adherence. Participants will choose their preferred location (research center, community room, or outdoor park). Exercise intensity will be self-selected by participants during the first two weeks, then gradually progressed toward a moderate intensity target (50-60% of heart rate reserve), monitored using a heart rate monitor at each session.
Recruitment rate
Number of patients contacted per month for eligibility screening. Success threshold: ≥ 6 patients/month
Time frame: Over the recruitment period (up to 9 months)
Enrollment rate
Number of participants enrolled in the study per month
Time frame: Over the recruitment period (up to 9 months)
Study refusal rate
Percentage of eligible people who decline to participate
Time frame: Over the recruitment period (up to 9 months)
Eligibility rate
Percentage of screened individuals who meet eligibility criteria
Time frame: Over the recruitment period (up to 9 months)
Randomization acceptance rate
Percentage of eligible, consenting participants who accept randomization
Time frame: At the time of enrollment
Retention rate by group
Percentage of participants retained in each study arm (target: ≥ 70%, per section 4.3)
Time frame: From enrollment to the end of the intervention at 9 weeks
Intervention participation rate
Percentage of prescribed physical activity sessions attended (target: ≥ 80%, per section 4.3)
Time frame: Over the 9-week intervention period
EMA item response adherence rate
Percentage of completed ecological momentary assessment prompts on depressive symptoms (target: ≥ 60%, per section 4.3)
Time frame: Over the 9-week intervention period
Intervention acceptability
Assessed using a study-specific questionnaire (anticipated acceptability at T1, retrospective acceptability at T2) and semi-structured individual interviews conducted online via Zoom, based on an established acceptability framework
Time frame: At enrollment, at the end of the intervention (9 weeks), and during a follow-up interview within 4 weeks after the intervention ends
Depressive symptom dynamics (EMA-MADRS)
Ecological Momentary Assessment version of the Montgomery-Åsberg Depression Rating Scale (EMA-MADRS), administered via the BEIWE smartphone application
Time frame: Continuously throughout the 9-week intervention period
Depressive symptoms (Self report/CES-D)
Center for Epidemiologic Studies Depression Scale (CES-D)
Time frame: At baseline and at 9 weeks (end of intervention)
Depressive symptoms (clinician-rated/MADRS)
Montgomery-Åsberg Depression Rating Scale (MADRS)
Time frame: At baseline and at 9 weeks (end of intervention)
Anxiety symptoms (GAD-7)
Generalized Anxiety Disorder 7-item Scale (GAD-7)
Time frame: At baseline and at 9 weeks (end of intervention)
Physical condition (6-minute walk test)
Distance walked (in meters) during a standardized 6-minute walk test on a 30-meter corridor, administered according to the American Thoracic Society protocol
Time frame: At baseline and at 9 weeks (end of intervention)
Body mass index
Calculated from height and weight measured by a trained research assistant (kg/m²)
Time frame: At baseline and at 9 weeks (end of intervention)
Waist circumference
Measured twice above the iliac crest using a measuring tape by a trained research assistant; the average of the two measurements is used (cm)
Time frame: At baseline and at 9 weeks (end of intervention)
Physical activity and sedentary behavior
Simple Physical Activity Questionnaire (SIMPAQ)
Time frame: At baseline and at 9 weeks (end of intervention)
Lifestyle habits
Standardized self-reported questionnaire
Time frame: At baseline
Sociodemographic characteristics
Standardized self-reported questionnaire
Time frame: At baseline
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Jan 2027; primary completion for Dec 2027, 11 months later.
Of 3,680 non-industry interventional studies with no phase under Obesity, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's planned 11 months is below that.
Counting every sponsor, half of 3,843 studies reached it within 22 months; a quarter within 10 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Universite du Quebec en Outaouais