A Phase 3 interventional study of ZG005 for Injection and Etoposide Injection in Neuroendocrine Carcinomas (NEC), sponsored by Suzhou Zelgen Biopharmaceuticals Co.,Ltd. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-09-22.
Sponsored by Suzhou Zelgen Biopharmaceuticals Co.,Ltd · Phase 3, Interventional, and Treatment
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Among 39 studies in Carcinoma, Neuroendocrine with a site in China — 26 open to participants now, 27 under way, 4 of them phase 3. Carcinoma, Neuroendocrine · China.
Among the 39 studies in Carcinoma, Neuroendocrine with a site in China, this one is the 4th largest by planned enrollment of the 32 interventional ones that give a count, is one of 11 that started in 2026, is one of 4 in phase 3, reaches primary completion later than 26 of the 26 other live ones, and was the 37th registered.
172 studies on the registry are indexed under Carcinoma, Neuroendocrine; 66 are open to participants now.
Browse Carcinoma, Neuroendocrine studies →26 of the 39 studies in Carcinoma, Neuroendocrine with a site in China are open now. Recruiting first, the newest first:
Sun Yat-sen University · Sites in China
Ages 18–75
The First Affiliated Hospital of Xiamen University · Sites in China
Ages 18–80
Suzhou Zelgen Biopharmaceuticals Co.,Ltd · Sites in China
Ages 18–70
Hansoh BioMedical R&D Company · Sites in China
Ages 18+
Fudan University · Sites in China
Ages 18+
A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →
Of the 47 Carcinoma, Neuroendocrine studies recruiting now, 30 (64%) set no upper age limit and 10 (21%) stop at 75 or younger; 2 take children under 18; none take healthy volunteers.
This study: 18 Years to 75 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
39 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 11 · Phase 2 24 · Phase 3 5 · Phase 4 1
First in 2008; this study’s year is marked. 11 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 440 is above the median of 60 across 144 interventional studies indexed under Carcinoma, Neuroendocrine.
Median enrollment 80 across the 32 interventional studies, 120 across the 7 observational. Of the 5 that completed or were terminated, 1 (20%) have results posted.
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14 of 39 have an industry lead sponsor. The 10 most frequent:
Suzhou Zelgen Biopharmaceuticals Co.,Ltd is the lead sponsor of 83 studies on the registry; 29 are open to participants now.
Suzhou Zelgen Biopharmaceuticals Co.,Ltd has 7 studies filed under Carcinoma, Neuroendocrine — fewer than ten, so there is no comparison to draw.
11 of the studies in Carcinoma, Neuroendocrine with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06070740Peking Union Medical College HospitalFirst- Line Treatment With Durvalumab Plus XELOX Chemotherapy in Advanced Gastrointestinal Neuroendocrine Carcinoma | 2026-11-30 |
| NCT07911423Peking Union Medical College HospitalImmunotherapy in Neuroendocrine Carcinoma of the Cervix | 2026-12-01 |
| NCT07879339Peking Union Medical College HospitalMulti-omics Study of Cervical Neuroendocrine Carcinoma | 2026-12-01 |
| NCT06157827Nanjing Leads Biolabs Co.,LtdA Clinical Trial of LBL-024 Combined With Etoposide and Platinum in Patients With Advanced Neuroendocrine Carcinoma | 2026-12-28 |
| NCT07014540Beijing GoBroad HospitalA Irinotecan Liposome Trial of in Advanced Neuroendocrine Carcinoma | 2026-12-31 |
Add all 11 to your calendar (.ics) → With an account.
Among the 39 studies in Carcinoma, Neuroendocrine with a site in China, from their registry updates:
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This is a randomized, double-blind, controlled, multicenter Phase III study evaluating the efficacy, safety, pharmacokinetics, and immunogenicity of ZG005 combined with the EP regimen (etoposide plus cisplatin) in participants with advanced NEC who are naive to systemic therapy.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
A scale of how much an illness limits everyday activity. For people being assessed to join a study, scores run from 0 (fully active) to 4; lower is more active.
Studies most often ask for 0–1 or 0–2. Your doctor gives the score; the WHO scale uses the same steps. The full scale also has 5, which records death.
Cancer that has spread to the leptomeninges, the thin layers covering the brain and spinal cord, and the fluid between them. It is not the same as brain metastases.
Criteria often treat it separately, and many studies leave it out even where treated brain metastases are allowed.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Life expectancy
The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Histologically or cytologically confirmed
The diagnosis was confirmed by looking at a sample under a microscope: tissue from a biopsy or surgery (histology), or cells from a fluid or needle sample (cytology).
Your pathology report is the document that shows this.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ECOG performance status
A scale of how much an illness limits everyday activity. For people being assessed to join a study, scores run from 0 (fully active) to 4; lower is more active.
Studies most often ask for 0–1 or 0–2. Your doctor gives the score; the WHO scale uses the same steps. The full scale also has 5, which records death.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Leptomeningeal disease
Cancer that has spread to the leptomeninges, the thin layers covering the brain and spinal cord, and the fluid between them. It is not the same as brain metastases.
Criteria often treat it separately, and many studies leave it out even where treated brain metastases are allowed.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Treatment arm
Drug: ZG005 for Injection · Drug: Etoposide Injection · Drug: Cisplatin Injection
Control arm
Drug: Etoposide Injection · Drug: Cisplatin Injection · Drug: ZG005 placebo for injection
Intravenous infusion
Intravenous infusion
Intravenous infusion
Intravenous infusion
Overall survival (OS)
Time frame: Up to 48 months
Progression-free survival (PFS)
Time frame: Up to 48 months
Objective Response Rate (ORR)
Time frame: Up to 48 months
Duration of response (DoR)
Time frame: Up to 48 months
Occurrence of adverse event (AE) and serious adverse event (SAE)
Time frame: Up to 48 months
Start is estimated for Oct 2026; primary completion for Oct 2031, 60 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Nilvanstomig
Suzhou Zelgen Biopharmaceuticals Co.,Ltd →