An interventional study of Optokinetic stimulation without reading task and Optokinetic stimulation with reading task in Hemianopia Homonymous and Stroke, sponsored by Clinique Les Trois Soleils. Not yet recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by Clinique Les Trois Soleils · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to investigate whether optokinetic stimulation delivered without a reading task can improve reading performance in adults with post-stroke hemianopic alexia. The main question it aims to answer is: does optokinetic stimulation without a reading task improve reading speed more than optokinetic stimulation with a reading task? Optokinetic stimlation with a reading task is considered the standard rehabilitation. These two conditions will be administered according to a randomized crossover design to determine wether the presence or absence of a reading task influences reading outcomes.
Participants will
Stroke can cause a visual field defect known as homonymous hemianopia (HH). When this visual field loss involves the macula, the central area of vision, it may result in reading difficulties known as hemianopic alexia (HA).
The literature reports improved reading performance in these patients after repeated induction of horizontal optokinetic nystagmus (i.e., an oculomotor reflex consisting of horizontal saccades). To induce this nystagmus, previous studies have used a reading task involving text scrolling from right to left.
However, this type of exercise, which relies on reading, is cognitively demanding and may lead to frustration due to reading difficulties, fatigue, and reduced motivation and potentially the impact of rehabilitation. Therefore, the use of a non-reading task could help overcome these limitations.
The present study aims to compare the efficacy of optokinetic stimulation with reading to optokinetic stimulation without reading in patients with HA.
63 studies on the registry are indexed under Hemianopsia; 24 are open to participants now.
This study's planned enrollment of 30 is close to the median of 32 across 53 interventional studies indexed under Hemianopsia.
Browse Hemianopsia studies →Clinique Les Trois Soleils is the lead sponsor of 6 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients receive 15 sessions of optokinetic rehabilitation with a reading task, followed by 15 sessions of optokinetic rehabilitation without an associated reading task. The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control.
Other: Optokinetic stimulation without reading task · Other: Optokinetic stimulation with reading task
Patients receive 15 sessions of optokinetic rehabilitation without an associated reading task, followed by 15 sessions of optokinetic rehabilitation with a reading task. The optokinetic rehabilitation sessions with reading are considered the standard of care, while optokinetic rehabilitation without an associated reading task is the experimental condition. Each patient undergoes both conditions sequentially and serves as their own control.
Other: Optokinetic stimulation without reading task · Other: Optokinetic stimulation with reading task
Participants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of viewing random sequences of letters scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation.
Participants are exposed to a horizontally moving optokinetic visual stimulus on a computer screen for 40 minutes per session. The task consists of reading aloud sentences scrolling from right to left. The sessions are spread out over 4 weeks, with 3 or 4 sessions per week, to achieve 10 hours (15 sessions) of optokinetic rehabilitation. The scrolling speed ranges from 85 to 275 words per minute, depending on the participant's reading accuracy.
Change in reading speed on paper
Change in the number of correctly read words per minute, assessed using the International Reading Speed Texts (IReST). For each participant, the change in reading speed will be calculated separately for the optokinetic rehabilitation condition with a reading task and for the optokinetic rehabilitation condition without a reading task. The within-participant changes obtained after each 4-week period will be pooled across the two randomized sequences and compared between conditions. A higher reading speed indicates better reading performance.
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading accuracy on paper
Change in the number and type of errors (paralexias, omissions) assessed using the International Reading Speed Texts (IReST).
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading speed on screen
Change in the number of correctly read words per minute, assessed using a screen-based reading task
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in reading accuracy on screen
Change in the number and type of errors (paralexias, omissions), assessed during a screen-based reading task
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in subjective reading abilities
Change in the score on the Hemianopia Reading Questionnaire (HRQ)
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular fixations during reading
Change in the number of fixations and in the mean fixation duration (in ms) during the screen-based reading task, assessed with an eyetracker
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in ocular saccades during reading
Change in the number and in the mean amplitude of saccades (in degrees) during the screen-based reading task, assessed with an eyetracker
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in optokinetic nystagmus
Change of saccade amplitude and frequency during optokinetic stimulation
Time frame: Baseline and at the end of both rehabilitation: Week 0 and Week 8
Change in visual detection during standard perimetry
Change in visual sensitivity (in dB) at each tested visual field location on automated static perimetry (Humphrey or Octopus)
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Change in visual detection during screen-based perimetry
Change in number of correctly detected targets and mean reaction time (in ms) at each tested visual field location on screen-based perimetry
Time frame: Baseline and end of each 4-week rehabilitation period: Week 0, Week 4, and Week 8
Tolerability of rehabilitation
Score of fatigue, stress, and mood induced by the treatment, self-assessed using a numbered visual analogue scale
Time frame: Before and after each rehabilitation session
Motivation for rehabilitation
Score obtained on the Situational Motivation Scale
Time frame: End of each 4-week rehabilitation period: Week 4 and Week 8
Plan to share: No
Start is estimated for Oct 2026; primary completion for Jun 2027, 8 months later.
Of 36 interventional studies with no phase under Hemianopsia, half reached primary completion within 47 months of starting (the median), counting those still running; a quarter within 21 and three quarters within 95. This study's planned 8 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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