ClinicalTrials.gg
RecruitingNCT07635329BRIGHTUpdated Sep 14, 2026

Home-based Vision Rehabilitation Guided by Brain Imaging

An interventional study of High-level perceptual learning-based training and Low-level perceptual learning-based training in Visual Field Defect, Stroke and Hemianopia Homonymous, sponsored by Georgetown University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by Georgetown University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Jul 2026; still recruiting 3 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.

Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

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Conditions studied

  • Visual Field Defect
  • Stroke
  • Hemianopia Homonymous
  • Quadrantanopia
  • Cortical Blindness
  • Visual Field Defect, Peripheral
  • Visual Field Loss
  • Traumatic Brain Injury
  • Brain Tumor

Keywords

  • neuroplasticity
  • stroke
  • vision
  • TBI
  • brain tumor
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In context

Stroke

8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.

This study's planned enrollment of 100 is above the median of 49 across 6,024 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Georgetown University is the lead sponsor of 292 studies on the registry; 40 are open to participants now.

Of its 28 completed or terminated interventional studies of FDA-regulated products, 20 (71%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. At least 18 years of age.
  2. Capable of providing and complying with study procedures.
  3. Unilateral or bilateral focal brain damage causing visual field loss.
  4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
  5. Eligible for MRI based on standard safety screening.

Exclusion criteria

Exclusion Criteria:

  1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
  2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by .
  3. Ocular disease or disorder.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

DSM diagnostic criteria

The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.

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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
100 participants (estimated)

Study arms

  • Experimental
    Perceptual learning-based training using high-level visual stimuli

    A 3 week at-home online perceptual learning-based training using high-level visual stimuli.

    Behavioral: High-level perceptual learning-based training

  • Active comparator
    Perceptual learning-based training using low-level visual stimuli

    A 3 week at-home online perceptual learning-based training using low-level visual stimuli.

    Behavioral: Low-level perceptual learning-based training

Interventions

  • BehavioralHigh-level perceptual learning-based training

    Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing

  • BehavioralLow-level perceptual learning-based training

    behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

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What researchers measure

Primary outcomes

  1. Change in high-level perceptual discrimination performance

    Change in performance on an online computerized high-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

    Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)

  2. Change in low-level perceptual discrimination performance

    Change in performance on an online computerized low-level perceptual discrimination task. Participants complete a computerized high-level perceptual discrimination task during a 3-week training period (5 days per week). Task difficulty is adaptively adjusted using a 3-up/1-down staircase procedure to estimate perceptual discrimination thresholds corresponding to approximately 75% accuracy.

    Time frame: Week 2-4 or Week 7-9 of the study (depending on the order)

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Study locations

1 of 1 sites recruiting
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07635329
Collaborators
American Heart Association
Responsible party
Tong (Tina) Liu (Assistant Professor of Neurology, Georgetown University) — Principal investigator
First posted
Jun 9, 2026
Start date
Jul 23, 2026
Primary completion
Mar 31, 2030 (estimated)
Completion
Mar 31, 2030 (estimated)
Last update
Sep 14, 2026

Study contacts

Tina Liu, PhD
Contact
tina.liu@georgetown.edu
2027849920

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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